Tuberculosis in the context of "Sanatorium (resort)"

A microorganism, or microbe, is an organism of microscopic size, which may exist in its single-celled form or as a colony of cells. The possible existence of unseen microbial life was suspected from antiquity, with an early attestation in Jain literature authored in 6th-century BC India. The scientific study of microorganisms began with their observation under the microscope in the 1670s by Anton van Leeuwenhoek. In the 1850s, Louis Pasteur found that microorganisms caused food spoilage, debunking the theory of spontaneous generation. In the 1880s, Robert Koch discovered that microorganisms caused the diseases tuberculosis, cholera, diphtheria, and anthrax.

Microorganisms are extremely diverse, representing most unicellular organisms in all three domains of life: two of the three domains, Archaea and Bacteria, only contain microorganisms. The third domain, Eukaryota, includes all multicellular organisms as well as many unicellular protists and protozoans that are microbes. Some protists are related to animals and some to green plants. Many multicellular organisms are also microscopic, namely micro-animals, some fungi, and some algae.

Bacteria are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit the air, soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria play a vital role in many stages of the nutrient cycle by recycling nutrients and the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in mutualistic, commensal and parasitic relationships with plants and animals. Most bacteria have not been characterised and there are many species that cannot be grown in the laboratory. The study of bacteria is known as bacteriology, a branch of microbiology.

Like all animals, humans carry vast numbers (approximately 10 to 10) of bacteria. Most are in the gut, though there are many on the skin. Most of the bacteria in and on the body are harmless or rendered so by the protective effects of the immune system, and many are beneficial, particularly the ones in the gut. However, several species of bacteria are pathogenic and cause infectious diseases, including cholera, syphilis, anthrax, leprosy, tuberculosis, tetanus and bubonic plague. The most common fatal bacterial diseases are respiratory infections. Antibiotics are used to treat bacterial infections and are also used in farming, making antibiotic resistance a growing problem. Bacteria are important in sewage treatment and the breakdown of oil spills, the production of cheese and yogurt through fermentation, the recovery of gold, palladium, copper and other metals in the mining sector (biomining, bioleaching), as well as in biotechnology, and the manufacture of antibiotics and other chemicals.

Hermann Brehmer (14 August 1826 – 28 December 1889) was a German physician who established the first German sanatorium for the systematic open-air treatment of tuberculosis.

Fyodor Mikhailovich Dostoevsky (11 November [O.S. 30 October] 1821 – 9 February [O.S. 28 January] 1881) was a Russian novelist, short story writer, essayist and journalist. He is regarded as one of the greatest novelists in both Russian and world literature, and many of his works are considered highly influential masterpieces. Dostoevsky's literary works explore the human condition in the troubled political, social and spiritual atmospheres of 19th-century Russia, and engage with a variety of philosophical and religious themes. His most acclaimed novels include Crime and Punishment (1866), The Idiot (1869), Demons (1872), The Adolescent (1875) and The Brothers Karamazov (1880). His Notes from Underground, a novella published in 1864, is considered one of the first works of existentialist literature.

Born in Moscow in 1821, Dostoevsky was introduced to literature at an early age through fairy tales and legends and through books by Russian and foreign authors. His mother died of tuberculosis on 27 February 1837, when he was 15, and around the same time, he left school to enter the Nikolayev Military Engineering Institute (later renamed the Military Engineering-Technical University). After graduating, he worked as an engineer and briefly enjoyed a lavish lifestyle, translating books to earn extra money. In the mid-1840s, he wrote his first novel, Poor Folk, which gained him entry into Saint Petersburg's literary circles. However, he was arrested in 1849 for belonging to a literary group, the Petrashevsky Circle, that discussed banned books critical of Tsarist Russia. Dostoevsky was sentenced to death, but the sentence was commuted at the last moment. He spent four years in a Siberian prison camp, followed by six years of compulsory military service in exile. In the following years, Dostoevsky worked as a journalist, publishing and editing several magazines of his own and later A Writer's Diary, a collection of his writings. He began to travel around Western Europe and developed a gambling addiction, which led to financial hardship. For a time, he had to beg for money, but he eventually became one of the most widely read and highly regarded Russian writers.

Francis George Fowler (1871–1918) was an English writer on English language, grammar and usage.

Born in Tunbridge Wells, Fowler was educated at Peterhouse, Cambridge. He lived on Guernsey in the Channel Islands. He and his older brother, Henry Watson Fowler, wrote The King's English together, an influential book published in 1906. Later they worked on what became Fowler's Modern English Usage, but before it was finished, Francis died of tuberculosis, picked up during his service with the British Expeditionary Force in World War I. He was 47 years old.

Heinrich Hermann Robert Koch (/kɒx/ KOKH; German: [ˈʁoːbɛʁt kɔx] ; 11 December 1843 – 27 May 1910) was a German physician and microbiologist. As the discoverer of the specific causative agents of deadly infectious diseases including tuberculosis, cholera and anthrax, he is regarded as one of the main founders of modern bacteriology. As such he is popularly nicknamed the father of microbiology (with Louis Pasteur), and as the father of medical bacteriology. His discovery of the anthrax bacterium (Bacillus anthracis) in 1876 is considered as the birth of modern bacteriology. Koch used his discoveries to establish that germs "could cause a specific disease" and directly provided proofs for the germ theory of diseases, therefore creating the scientific basis of public health, saving millions of lives. For his life's work Koch is seen as one of the founders of modern medicine.

While working as a private physician, Koch developed many innovative techniques in microbiology. He was the first to use the oil immersion lens, condenser, and microphotography in microscopy. His invention of the bacterial culture method using agar and glass plates (later developed as the Petri dish by his assistant Julius Richard Petri) made him the first to grow bacteria in the laboratory. In appreciation of his work, he was appointed to government advisor at the Imperial Health Office in 1880, promoted to a senior executive position (Geheimer Regierungsrat) in 1882, Director of Hygienic Institute and Chair (Professor of hygiene) of the Faculty of Medicine at Berlin University in 1885, and the Royal Prussian Institute for Infectious Diseases (later renamed Robert Koch Institute after his death) in 1891.