Cyclostomi in the context of "Nostril"

Agnatha (/ˈæɡnəθə, æɡˈneɪθə/; from Ancient Greek ἀ- (a-) 'without' and γνάθος (gnáthos) 'jaws') or jawless fish is a paraphyletic infraphylum of animals in the subphylum Vertebrata of the phylum Chordata, characterized by the lack of jaws. The group consists of both living (cyclostomes such as hagfishes and lampreys) and extinct clades (e.g. conodonts and cephalaspidomorphs, among others). They are sister to vertebrates with jaws known as gnathostomes, who evolved from jawless ancestors during the early Silurian by developing folding articulations in the first pairs of gill arches.

Molecular data, both from rRNA and from mtDNA as well as embryological data, strongly supports the hypothesis that both groups of living agnathans, hagfishes and lampreys, are more closely related to each other than to jawed fish, forming the superclass Cyclostomi.

Cartilage is a resilient and smooth type of connective tissue. Semi-transparent and non-porous, it is usually covered by a tough and fibrous membrane called perichondrium. In tetrapods, it covers and protects the ends of long bones at the joints as articular cartilage, and is a structural component of many body parts including the rib cage, the neck and the bronchial tubes, and the intervertebral discs. In other taxa, such as chondrichthyans and cyclostomes, it constitutes a much greater proportion of the skeleton. It is not as hard and rigid as bone, but it is much stiffer and much less flexible than muscle or tendon. The matrix of cartilage is made up of glycosaminoglycans, proteoglycans, collagen fibers and, sometimes, elastin. It usually grows quicker than bone.

Because of its rigidity, cartilage often serves the purpose of holding tubes open in the body. Examples include the rings of the trachea, such as the cricoid cartilage and carina.

Hagfish, of the class Myxini /mɪkˈsaɪnaɪ/ (also known as Hyperotreti) and order Myxiniformes /mɪkˈsɪnɪfɔːrmiːz/, are eel-shaped jawless fish (occasionally called slime eels). Hagfish are the only known living animals that have a skull but no vertebral column, although they do have rudimentary vertebrae. Hagfish are marine predators and scavengers that can defend themselves against other larger predators by releasing copious amounts of slime from mucous glands in their skin.

Although their exact relationship to the only other living group of jawless fish, the lampreys, was long the subject of controversy, genetic evidence suggests that hagfish and lampreys are more closely related to each other than to jawed vertebrates, thus forming the superclass Cyclostomi. The oldest-known stem group hagfish are known from the Late Carboniferous, around 310 million years ago, with modern representatives first being recorded in the mid-Cretaceous around 100 million years ago.

Ostracodermi (lit. 'shell-skins') or ostracoderms is an informal group of vertebrate animals that include all armored jawless fish of the Paleozoic Era. The term does not often appear in classifications today because it is paraphyletic (excluding jawed fishes and possibly the cyclostomes if anaspids are closer to them) and thus does not correspond to one evolutionary lineage. However, the term is still used as an informal way of loosely grouping together the armored jawless fishes.

An innovation of ostracoderms was the use of gills not for feeding, but exclusively for respiration. Earlier chordates with gill precursors used them for both respiration and feeding. Ostracoderms had separate pharyngeal gill pouches along the side of the head, which were permanently open with no protective operculum. Unlike invertebrates that use ciliated motion to move food, ostracoderms used their muscular pharynx to create a suction that pulled small and slow-moving prey into their mouths.

Myomeres are blocks of skeletal muscle tissue arranged in sequence, commonly found in aquatic chordates. Myomeres are separated from adjacent myomeres by fascia consisting of connective tissue, known as myosepta. Myomere counts are sometimes used for identifying specimens using meristics, since their number corresponds to the number of vertebrae in the adults. Myomere location varies, with some species containing these only near the tails, while some have them located near the scapular or pelvic girdles. Depending on the species, myomeres could be arranged in an epaxial or hypaxial manner; hypaxial refers to ventral muscles (those of the "stomach" region) and related structures, while epaxial refers to more dorsal muscles (those of the "back"). The horizontal septum divides these two regions in vertebrates from cyclostomes (jawless lamprey and hagfish) to gnathostomes (jawed fish). In terrestrial chordates, which are gnathostomes themselves, the myomeres become fused as well as indistinct, due to the disappearance of myosepta.