Syphilis in the context of Benzylpenicillin

Human to animal breastfeeding has been practiced in some different cultures during various time periods. The practice of breastfeeding or suckling between humans and other species occurred in both directions: women sometimes breastfed young animals, and animals were used to suckle babies and children. Animals were used as substitute wet nurses for infants, particularly after the rise of syphilis increased the health risks of wet nursing. Goats and donkeys were widely used to feed abandoned babies in foundling hospitals in 18th- and 19th-century Europe. Breastfeeding animals has also been practised, whether for perceived health reasons – such as to toughen the nipples and improve the flow of milk – or for religious and cultural purposes. A wide variety of animals have been used for this purpose, including puppies, kittens, piglets and monkeys.

Bacteria are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit the air, soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria play a vital role in many stages of the nutrient cycle by recycling nutrients and the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in mutualistic, commensal and parasitic relationships with plants and animals. Most bacteria have not been characterised and there are many species that cannot be grown in the laboratory. The study of bacteria is known as bacteriology, a branch of microbiology.

Like all animals, humans carry vast numbers (approximately 10 to 10) of bacteria. Most are in the gut, though there are many on the skin. Most of the bacteria in and on the body are harmless or rendered so by the protective effects of the immune system, and many are beneficial, particularly the ones in the gut. However, several species of bacteria are pathogenic and cause infectious diseases, including cholera, syphilis, anthrax, leprosy, tuberculosis, tetanus and bubonic plague. The most common fatal bacterial diseases are respiratory infections. Antibiotics are used to treat bacterial infections and are also used in farming, making antibiotic resistance a growing problem. Bacteria are important in sewage treatment and the breakdown of oil spills, the production of cheese and yogurt through fermentation, the recovery of gold, palladium, copper and other metals in the mining sector (biomining, bioleaching), as well as in biotechnology, and the manufacture of antibiotics and other chemicals.

Hearing loss is a partial or total inability to hear. Hearing loss may be present at birth or acquired at any time afterwards. Hearing loss may occur in one or both ears. In children, hearing problems can affect the ability to acquire spoken language. In adults, it can create difficulties with social interaction and at work. Hearing loss can be temporary or permanent. Hearing loss related to age usually affects both ears and is due to cochlear hair cell loss. In some people, particularly older people, hearing loss can result in loneliness.

Hearing loss may be caused by a number of factors, including: genetics, ageing, exposure to noise, some infections, birth complications, trauma to the ear or brain, and certain medications or toxins. A common condition that results in hearing loss is chronic ear infections. Certain infections during pregnancy, such as cytomegalovirus, syphilis and rubella, may also cause hearing loss in the child. Hearing loss is diagnosed when hearing testing finds that a person is unable to hear 25 decibels in at least one ear. Testing for poor hearing is recommended for all newborns. Hearing loss can be categorized as minimal/slight (15 to 25 dB), mild (25 to 40 dB), moderate (41 to 55 dB), moderate-severe (56 to 70 dB), severe (71 to 90 dB), or profound (greater than 90 dB). There are three main types of hearing loss: conductive hearing loss, sensorineural hearing loss, and mixed hearing loss.

The Hawaiian Kingdom, also known as the Kingdom of Hawaiʻi (Hawaiian: Ke Aupuni Hawaiʻi [kɛ ɐwˈpuni həˈvɐjʔi]), was an archipelagic country from 1795 to 1893, which eventually encompassed all of the inhabited Hawaiian Islands. It was established in 1795 when Kamehameha I, then Aliʻi nui of Hawaii, conquered the islands of Oʻahu, Maui, Molokaʻi, and Lānaʻi, and unified them under one government. In 1810, the Hawaiian Islands were fully unified when the islands of Kauaʻi and Niʻihau voluntarily joined the Hawaiian Kingdom. Two major dynastic families ruled the kingdom, the House of Kamehameha and the House of Kalākaua.

The kingdom subsequently gained diplomatic recognition from European powers and the United States. An influx of European and American explorers, traders, and whalers soon began arriving to the kingdom, introducing diseases such as syphilis, tuberculosis, smallpox, and measles, leading to the rapid decline of the Native Hawaiian population. In 1887, King Kalākaua was forced to accept a new constitution after a coup d'état by the Honolulu Rifles, a volunteer military unit recruited from American settlers. Queen Liliʻuokalani, who succeeded Kalākaua in 1891, tried to abrogate the new constitution. She was subsequently overthrown in a 1893 coup engineered by the Committee of Safety, a group of Hawaiian subjects who were mostly of American descent, and supported by the U.S. military. The Committee of Safety dissolved the kingdom and established the Republic of Hawaii, intending for the U.S. to annex the islands, which it did on July 7, 1898, via the Newlands Resolution. Hawaii became part of the U.S. as the Territory of Hawaii until it became a U.S. state in 1959.

A sexually transmitted infection (STI), also referred to as a sexually transmitted disease (STD) and the older term venereal disease (VD), is an infection that is spread by sexual activity, especially vaginal intercourse, anal sex, oral sex, or sometimes manual sex. STIs often do not initially cause symptoms, which results in a risk of transmitting them to others. The term sexually transmitted infection is generally preferred over sexually transmitted disease or venereal disease, as it includes cases with no symptomatic disease. Symptoms and signs of STIs may include vaginal discharge, penile discharge, ulcers on or around the genitals, and pelvic pain. Some STIs can cause infertility.

Bacterial STIs include chlamydia, gonorrhea, and syphilis. Viral STIs include genital warts, genital herpes, and HIV/AIDS. Parasitic STIs include trichomoniasis. Most STIs are treatable and curable; of the most common infections, syphilis, gonorrhea, chlamydia, and trichomoniasis are curable, while HIV/AIDS and genital herpes are not curable. Some vaccinations may decrease the risk of certain infections including hepatitis B and a few types of HPV. Safe sex practices such as the use of condoms, having smaller number of sexual partners, and being in a relationship in which each person only has sex with the other also decreases STIs risk. Comprehensive sex education may also be useful.

Mercury(II) chloride (mercury bichloride, mercury dichloride, mercuric chloride), historically also sulema or corrosive sublimate, is the inorganic chemical compound of mercury and chlorine with the formula HgCl₂, used as a laboratory reagent. It is a white crystalline solid and a molecular compound that is very toxic to humans. Once used as a first line treatment for syphilis, it has been replaced by the more effective and less toxic procaine penicillin since at least 1948.

Stillbirth is typically defined as the death of a fetus at or after 20 or 28 weeks of pregnancy, depending on the source. It results in a baby born without signs of life. A stillbirth can often result in the feeling of guilt or grief in the mother. The term is in contrast to miscarriage, which is an early pregnancy loss, and sudden infant death syndrome, where the baby dies a short time after being born alive.

Often the cause is unknown. Causes may include pregnancy complications such as pre-eclampsia and birth complications, problems with the placenta or umbilical cord, birth defects, infections such as malaria and syphilis, and poor health in the mother. Risk factors include a mother's age over 35, smoking, drug use, use of assisted reproductive technology, and first pregnancy. Stillbirth may be suspected when no fetal movement is felt. Confirmation is by ultrasound.

Anna Maria Luisa de' Medici (11 August 1667 – 18 February 1743) was an Italian noblewoman who was the last lineal descendant of the main branch of the House of Medici. A patron of the arts, she bequeathed the Medicis' large art collection, including the contents of the Uffizi, Palazzo Pitti, and the Medici villas, which she inherited upon her brother Gian Gastone's death in 1737, and her Palatine treasures to the Tuscan state, on the condition that no part of it could be removed from "the Capital of the grand ducal State....[and from] the succession of His Serene Grand Duke."

Anna Maria Luisa was the only daughter of Cosimo III de' Medici, Grand Duke of Tuscany, and Marguerite Louise d'Orléans, a niece of Louis XIII of France. On her marriage to Johann Wilhelm, Elector Palatine, she became Electress of the Palatinate, and, by patronising musicians, she earned for the contemporary Palatine court the reputation of an important music centre. As Johann Wilhelm had syphilis the union produced no offspring, which, combined with her siblings' barrenness, meant that the Medici were on the verge of extinction.

Franz Peter Schubert (/ˈʃuːbərt/; German: [fʁants ˈpeːtɐ ˈʃuːbɐt]; 31 January 1797 – 19 November 1828) was an Austrian composer of the late Classical and early Romantic eras. Despite his short life, Schubert left behind a vast oeuvre, including more than 600 Lieder (art songs in German) and other vocal works, seven complete symphonies, sacred music, operas, incidental music, and a large body of piano and chamber music. His major works include "Erlkönig", "Gretchen am Spinnrade", and "Ave Maria"; the Trout Quintet; the Symphony No. 8 in B minor (Unfinished); the Symphony No. 9 in C major (The Great); the String Quartet No. 14 in D minor (Death and the Maiden); the String Quintet in C major; the Impromptus for solo piano; the last three piano sonatas; the Fantasia in F minor for piano four hands; the opera Fierrabras; the incidental music to the play Rosamunde; Schwanengesang; and the song cycles Die schöne Müllerin and Winterreise.

Born in the Himmelpfortgrund suburb of Vienna, Schubert showed uncommon gifts for music from an early age. His father gave him his first violin lessons and his elder brother gave him piano lessons, but Schubert soon exceeded their abilities. In 1808, at the age of eleven, he became a pupil at the Stadtkonvikt school, where he became acquainted with the orchestral music of Joseph Haydn, Wolfgang Amadeus Mozart, and Ludwig van Beethoven. He left the Stadtkonvikt at the end of 1813 and returned home to live with his father, where he began studying to become a schoolteacher. Despite this, he continued his studies in composition with Antonio Salieri and still composed prolifically. In 1821, Schubert was admitted to the Gesellschaft der Musikfreunde as a performing member, which helped establish his name among the Viennese citizenry. He gave a concert of his works to critical acclaim in March 1828, the only time he did so in his career. He died eight months later at the age of 31, the cause officially attributed to typhoid fever, but believed by some historians to be syphilis.

Disfigurement is the state of having one's appearance deeply and persistently harmed medically, such as from a disease, birth defect, or wound. General societal attitudes towards disfigurement have varied greatly across cultures and over time, with cultures possessing strong social stigma against it often causing psychological distress to disfigured individuals. Alternatively, many societies have regarded some forms of disfigurement in a medical, scientific context where someone having ill will against the disfigured is viewed as anathema. In various religious and spiritual contexts, disfigurement has been variously described as being a punishment from the divine for sin (such as Yahweh's defacement of Cain for Abel's murder in Judaism), as being (such as Paul of the New Testament's arguments about Christ's sufferings) caused by supernatural forces of hate and evil against the good and just, which will be later atoned for, or as being without explanation per se with people just having to endure.

The topic has been frequently commented on and referred to in a great many forms of fictional media as well. Villainous examples include the iconic fiend The Joker from various DC Comics and the mysterious figure with a "red right hand" from the song of the same name by the band Nick Cave and the Bad Seeds. Heroic examples include Daredevil, a crime-fighter who was rendered blind (from Marvel Comics), and the compassionate character Edward Scissorhands from the film of the same name. Antiheroic examples include Deadpool, a mercenary whose healing factor gives his skin a scarred appearance, and The Punisher, who has facial disfigurement, also from Marvel Comics.

Treponema pallidum, formerly known as Spirochaeta pallida, is a microaerophilic, gram-negative, spirochaete bacterium with subspecies that cause the diseases syphilis, bejel (also known as endemic syphilis), and yaws. It is known to be transmitted only among humans and baboons. T. pallidum can enter the host through mucosal membranes or open lesions in the skin and is primarily spread through sexual contact. It is a helically coiled microorganism usually 6–15 μm long and 0.1–0.2 μm wide. T. pallidum's lack of both a tricarboxylic acid cycle and processes for oxidative phosphorylation results in minimal metabolic activity. As a chemoorganoheterotroph, Treponema pallidum is an obligate parasite that acquires its glucose carbon source from its host. Glucose can be used not only as a primary carbon source but also in glycolytic mechanisms to generate ATP needed to power the bacterium given its minimal genome. The treponemes have cytoplasmic and outer membranes. Using light microscopy, treponemes are visible only by using dark-field illumination. T. pallidum consists of three subspecies, T. p. pallidum, T. p. endemicum, and T. p. pertenue, each of which has a distinct related disorder. The ability of T. pallidum to avoid host immune defenses has allowed for stealth pathogenicity. The unique outer membrane structure and minimal expression of surface proteins of T. pallidum has made vaccine development difficult. Treponema pallidum can be treated with high efficacy by antibiotics that inhibit bacterial cell wall synthesis such as the beta-lactam antimicrobial penicillin-G.

A chancre (/ˈʃæŋkər/ SHANG-kər) is a painless genital ulcer most commonly formed during the primary stage of syphilis. This infectious lesion forms around 21 days after the initial exposure to Treponema pallidum, the gram-negative spirochaete bacterium causing syphilis, but can range from 10 to 90 days. Without treatment it may persist for two to six weeks before healing. Chancres transmit syphilis through direct physical contact. These ulcers usually form on or around the anus, mouth, penis and vulva.

Chancres are also associated with the African trypanosomiasis (sleeping sickness), surrounding the area of the tsetse fly bite.

A gumma (plural gummata or gummas) is a soft, non-cancerous growth resulting from the tertiary stage of syphilis (and yaws).

It is a form of granuloma. Gummas are most commonly found in the liver (gumma hepatis), but can also be found in brain, heart, skin, bone, testis, and other tissues, leading to a variety of potential problems including neurological disorders or heart valve disease.