Paranoia in the context of Anxiety

The Tragedy of Macbeth, often shortened to Macbeth (/məkˈbɛθ/), is a tragedy by William Shakespeare, estimated to have been first performed in 1606. It dramatises the physically violent and damaging psychological effects of political ambitions and power. It was first published in the Folio of 1623, possibly from a prompt book, and is Shakespeare's shortest tragedy. Scholars believe Macbeth, of all the plays that Shakespeare wrote during the reign of King James I, contains the most allusions to James, patron of Shakespeare's acting company.

In the play, a brave Scottish general named Macbeth receives a prophecy from a trio of witches that one day he will become King of Scotland. Consumed by his latent ambition and spurred to violence by his wife, Macbeth murders King Duncan and takes the Scottish throne for himself. Then, racked with guilt and paranoia, he commits further murders to protect himself from enmity and suspicion, becoming a tyrannical ruler in the process. The violence perpetrated by the power-hungry couple leads to their insanity and finally to their deaths.

A conspiracy theory is an explanation for an event or situation that asserts the existence of a conspiracy (generally by powerful sinister groups, often political in motivation), when other explanations are more probable. The term generally has a negative connotation, implying that the appeal of a conspiracy theory is based in prejudice, emotional conviction, insufficient evidence, and/or paranoia. A conspiracy theory is distinct from a conspiracy; it refers to a hypothesized conspiracy with specific characteristics, including but not limited to opposition to the mainstream consensus among those who are qualified to evaluate its accuracy, such as scientists or historians. As such, conspiracy theories are identified as lay theories.

Conspiracy theories are generally designed to resist falsification either by evidence against them or a lack of evidence for them. They are reinforced by circular reasoning: both evidence against the conspiracy and absence of evidence for it are misinterpreted as evidence of its truth. Psychologist Stephan Lewandowsky observes "the stronger the evidence against a conspiracy, the more the conspirators must want people to believe their version of events." As a consequence, the conspiracy becomes a matter of faith rather than something that can be proven or disproven. Studies have linked belief in conspiracy theories to distrust of authority and political cynicism. Some researchers suggest that conspiracist ideation—belief in conspiracy theories—may be psychologically harmful or pathological. Such belief is correlated with psychological projection, paranoia, and Machiavellianism.

Self-consciousness is a heightened sense of awareness of oneself. Historically, "self-consciousness" was synonymous with "self-awareness", referring to a state of awareness that one exists and that one has consciousness. While "self-conscious" and "self-aware" are still sometimes used interchangeably, particularly in philosophy, "self-consciousness" has commonly come to refer to a preoccupation with oneself, especially with how others might perceive one's appearance or one's actions. An unpleasant feeling of self-consciousness may occur when one realizes that one is being watched or observed, the feeling that "everyone is looking" at oneself. Some people are habitually more self-conscious than others. Unpleasant feelings of self-consciousness sometimes become associated with shyness or paranoia.

Notable opponents of self-consciousness include Thomas Carlyle.

Antipsychotics, previously known as neuroleptics and major tranquilizers, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of other psychotic disorders. They are also the mainstay, together with mood stabilizers, in the treatment of bipolar disorder. Moreover, they are also used as adjuncts in the treatment of treatment-resistant major depressive disorder.

The use of antipsychotics may result in many unwanted side effects such as involuntary movement disorders, gynecomastia, impotence, weight gain and metabolic syndrome. Long-term use can produce adverse effects such as tardive dyskinesia, tardive dystonia, tardive akathisia, and brain tissue volume reduction.

Cannabis (/ˈkænəbɪs/), commonly known as marijuana (/ˌmærəˈwɑːnə/), weed, pot, and ganja, among other names, is a non-chemically uniform psychoactive drug from the Cannabis plant. Native to Central or South Asia, cannabis has been used as a drug for both recreational and entheogenic purposes and in various traditional medicines for centuries. Tetrahydrocannabinol (THC) is the main psychoactive component of cannabis, which is one of the 483 known compounds in the plant, including at least 65 other cannabinoids, such as cannabidiol (CBD). Cannabis can be used by smoking, vaporizing, within food, or as an extract.

Cannabis has various mental and physical effects, which include euphoria, altered states of mind and sense of time, difficulty concentrating, impaired short-term memory, impaired body movement (balance and fine psychomotor control), relaxation, and an increase in appetite. Onset of effects is felt within minutes when smoked, but may take up to 90 minutes when eaten (as orally consumed drugs must be digested and absorbed). The effects last for two to six hours, depending on the amount used. At high doses, mental effects can include anxiety, delusions (including ideas of reference), hallucinations, panic, paranoia, and psychosis. There is a strong relation between cannabis use and the risk of psychosis, though the direction of causality is debated. Physical effects include increased heart rate, difficulty breathing, nausea, and behavioral problems in children whose mothers used cannabis during pregnancy; short-term side effects may also include dry mouth and red eyes. Long-term adverse effects may include addiction, decreased mental ability in those who started regular use as adolescents, heart disease, chronic coughing, susceptibility to respiratory infections, and cannabinoid hyperemesis syndrome.

Lysergic acid diethylamide, commonly known as LSD (from German Lysergsäurediethylamid) and by the slang names acid and lucy, is a semisynthetic hallucinogenic drug derived from ergot, known for its powerful psychological effects and serotonergic activity. It was historically used in psychiatry and 1960s counterculture; it is currently legally restricted but experiencing renewed scientific interest and increasing use.

When taken orally, LSD has an onset of action within 0.4 to 1.0 hours (range: 0.1–1.8 hours) and a duration of effect lasting 7 to 12 hours (range: 4–22 hours). It is commonly administered via tabs of blotter paper. LSD is extremely potent, with noticeable effects at doses as low as 20 micrograms and is sometimes taken in much smaller amounts for microdosing. Despite widespread use, no fatal human overdoses have been documented. LSD is mainly used recreationally or for spiritual purposes. LSD can cause mystical experiences. LSD exerts its effects primarily through high-affinity binding to several serotonin receptors, especially 5-HT_2A, and to a lesser extent dopaminergic and adrenergic receptors. LSD reduces oscillatory power in the brain's default mode network and flattens brain hierarchy. At higher doses, it can induce visual and auditory hallucinations, ego dissolution, and anxiety. LSD use can cause adverse psychological effects such as paranoia and delusions and may lead to persistent visual disturbances known as hallucinogen persisting perception disorder (HPPD).

Thomas Ruggles Pynchon Jr. (/ˈpɪntʃɒn/ PIN-chon, commonly /ˈpɪntʃən/ PIN-chən; born May 8, 1937) is an American novelist. He is noted for his complex works of postmodern fiction, characterized by dense references to popular culture, history, literature, music, science, and mathematics, as well as by humor and explorations of paranoia. He is widely regarded as one of the greatest American novelists. Pynchon is notoriously reclusive. Few photographs of him have been published, and rumors about his location and identity have circulated since the 1960s.

Born on Long Island, Pynchon served two years in the United States Navy and earned an English degree from Cornell University. After publishing several short stories in the late 1950s and early 1960s, he began composing the novels for which he is best known: V. (1963), The Crying of Lot 49 (1966), and Gravity's Rainbow (1973). For the latter, Pynchon won the 1974 U.S. National Book Award for Fiction. Pynchon followed with the novels Vineland (1990), which was loosely adapted for film as One Battle After Another in 2025, Mason & Dixon (1997), Against the Day (2006), Inherent Vice (2009), which was adapted for film in 2014, and Bleeding Edge (2013). Pynchon's latest novel, Shadow Ticket, was published in 2025.

Mania (/meɪniːˈə/ MAIN-ee-yah; also known as manic syndrome) is a psychiatric behavioral syndrome defined as a state of abnormally elevated arousal, affect, and energy level. During a manic episode, an individual will experience rapidly changing emotions and moods, highly influenced by surrounding stimuli. Although mania is often conceived of as a "mirror image" to depression, the heightened mood can be dysphoric as well as euphoric. As the mania intensifies, irritability can be more pronounced and result in anxiety or anger.

The symptoms of mania include elevated mood (either euphoric or irritable), flight of ideas, pressure of speech, increased energy, decreased "need" and desire for sleep, and hyperactivity. They are most plainly evident in fully developed hypomanic states, however, in full-blown mania, these symptoms become progressively exacerbated. In severe manic episodes, these symptoms may even be obscured by other signs and symptoms characteristic of psychosis, such as delusions (it may include delusions of grandeur and paranoid delusions), hallucinations, fragmentation of behavior, and catatonia.

Paranoid personality disorder (PPD) is a personality disorder characterized by paranoia, and a pervasive, long-standing suspiciousness and generalized mistrust of others. People with this disorder may be hypersensitive, easily insulted, and habitually relate to the world by vigilant scanning of the environment for clues or suggestions that may validate their fears or biases. They are eager observers and they often think they are in danger and look for signs and threats of that danger, potentially not appreciating other interpretations or evidence.

They tend to be guarded and suspicious and have quite constricted emotional lives. Their reduced capacity for meaningful emotional involvement and the general pattern of isolated withdrawal often lend a quality of loneliness to their life experience. People with PPD may have a tendency to bear grudges, suspiciousness, tendency to interpret others' actions as hostile, persistent tendency to self-reference, or a tenacious sense of personal right. Patients with this disorder can also have significant comorbidity with other personality disorders, such as schizotypal, schizoid, narcissistic, avoidant, and borderline.

A cannabis edible, also known as a cannabis-infused food or simply an edible, is a food item (either homemade or produced commercially) that contains decarboxylated cannabinoids (cannabinoid acids converted to their orally bioactive form) from cannabis extract as an active ingredient. Although edible may refer to either a food or a drink, a cannabis-infused drink may be referred to more specifically as a liquid edible or drinkable. Edibles are one of several methods used to consume cannabis. Unlike smoking, in which cannabinoids are inhaled into the lungs and pass rapidly into the bloodstream, peaking in about ten minutes and wearing off in a couple of hours, cannabis edibles may take hours to digest, and their effects may peak two to three hours after consumption and persist for around six hours. The food or drink used may affect both the timing and potency of the dose ingested.

Most edibles contain a significant amount of THC, which can induce a wide range of effects, including: heightened sensory perception, relaxation, sleepiness, dizziness, dry mouth, euphoria, depersonalization and/or derealization, hallucinations, paranoia, and decreased or increased anxiety. THC-dominant edibles are consumed for recreational and medical purposes. Some edibles contain a negligible amount of THC and are instead dominant in other cannabinoids, most commonly cannabidiol (CBD). The main characteristic of cannabis edibles is that they take longer to affect users compared to smoked cannabis.

A conspiracy theory is an explanation for an event or situation that asserts the existence of a conspiracy (generally by powerful sinister groups, often political in motivation), when other explanations are more probable. The term generally has a negative connotation, as it can often be based in prejudice, emotional conviction, insufficient evidence, and/or paranoia. A conspiracy theory is distinct from a conspiracy; it refers to a hypothesized conspiracy with specific characteristics, including but not limited to opposition to the mainstream consensus among those who are qualified to evaluate its accuracy, such as scientists or historians. As such, conspiracy theories are identified as lay theories.

Conspiracy theories are generally designed to resist falsification either by evidence against them or a lack of evidence for them. They are reinforced by circular reasoning: both evidence against the conspiracy and absence of evidence for it are misinterpreted as evidence of its truth. Psychologist Stephan Lewandowsky observes "the stronger the evidence against a conspiracy, the more the conspirators must want people to believe their version of events." As a consequence, the conspiracy becomes a matter of faith rather than something that can be proven or disproven. Studies have linked belief in conspiracy theories to distrust of authority and political cynicism. Some researchers suggest that conspiracist ideation—belief in conspiracy theories—may be psychologically harmful or pathological. Such belief is correlated with psychological projection, paranoia, and Machiavellianism.

Psychological thriller is a genre combining the thriller and psychological fiction genres. It is commonly used to describe literature or films that deal with psychological narratives in a thriller or thrilling setting.

In terms of context and convention, it is a subgenre of the broader ranging thriller narrative structure, with similarities to Gothic and detective fiction in the sense of sometimes having a "dissolving sense of reality". It is often told through the viewpoint of psychologically stressed characters, revealing their distorted mental perceptions and focusing on the complex and often tortured relationships between obsessive and pathological characters. Psychological thrillers often incorporate elements of mystery, drama, action, and paranoia. The genre overlaps with the psychological drama and psychological horror genres, the latter generally involving more horror and terror elements and themes and more disturbing or frightening scenarios.

Psychological horror is a subgenre of horror and psychological fiction with a particular focus on mental, emotional, and psychological states to frighten, disturb, or unsettle its audience. The subgenre frequently overlaps with the related subgenre of psychological thriller, and often uses mystery elements and characters with unstable, unreliable, or disturbed psychological states to enhance the suspense, horror, drama, tension, and paranoia of the setting and plot and to provide an overall creepy, unpleasant, unsettling, or distressing atmosphere.

Phencyclidine or phenylcyclohexyl piperidine (PCP), also known in its use as a street drug as angel dust among other names, is a dissociative anesthetic mainly used recreationally for its significant mind-altering effects. PCP may cause hallucinations, distorted perceptions of sounds, and psychotic behavior. As a recreational drug, it is typically smoked, but may be taken by mouth, snorted, or injected. It may also be mixed with cannabis or tobacco.

Adverse effects may include paranoia, addiction, and an increased risk of suicide, as well as seizures and coma in cases of overdose. Flashbacks may occur despite stopping usage. Chemically, PCP is a member of the arylcyclohexylamine class. PCP works primarily as an NMDA receptor antagonist.

A bad trip (also known as challenging experiences, acute intoxication from hallucinogens, psychedelic crisis, or emergence phenomenon) is an acute adverse psychological reaction to the effects of psychoactive substances, namely psychedelics. There is no clear definition of what constitutes a bad trip. Additionally, knowledge on the cause of bad trips and who may be vulnerable to such experiences are limited. Existing studies report that possible adverse reactions include anxiety, panic, depersonalization, ego dissolution, paranoia, as well as physiological symptoms such as dizziness and heart palpitations. However, most studies indicate that the set and setting of substance use influence how people respond.

Bad trips can be exacerbated by the inexperience or irresponsibility of the user or the lack of proper preparation and environment for the trip, and are often reflective of unresolved psychological tensions triggered during the course of the experience. In clinical research settings, precautions including the screening and preparation of participants, the training of the session monitors who will be present during the experience, and the selection of appropriate physical setting can minimize the likelihood of psychological distress. Researchers have suggested that the presence of professional "trip sitters" (i.e., session monitors) may significantly reduce the negative experiences associated with a bad trip. In most cases in which anxiety arises during a supervised psychedelic experience, reassurance from the session monitor is adequate to resolve it; however, if distress becomes intense it can be treated pharmacologically, for example with the benzodiazepine diazepam.