Novum Instrumentum Omne, later titled Novum Testamentum Omne, was a series of bilingual Latin-Greek New Testaments with substantial scholarly annotations, and the first printed New Testament of the Greek to be published. They were prepared by Desiderius Erasmus (1466–1536) in consultation with leading scholars, and printed by Johann Froben (1460–1527) of Basel. All five editions included Erasmus' collated and corrected Vulgate Latin version side-by-side with the Greek version, and the fourth edition also included his de novo rendition of the Greek into more refined Latin to bring out the similarities and difference from the Vulgate, for scholars not expert in Greek.
An estimate of up to 300,000 copies were printed in Erasmus' lifetime. After Erasmus' death, his New Testament work was republished and revised notably by Robert Stephanus: the corrected Latin Vulgate, shorn of mentions of Erasmus, soon became a reference text for the Leuven Vulgate which was ultimately the basis of the official Catholic Sixto-Clementine Vulgate Bible and subsequent Catholic vernacular translations; the Greek text was the basis for the majority of Protestant Textus Receptus translations of the New Testament in the 16th–19th centuries, including those of Martin Luther, William Tyndale and the King James Version.