The Massacre of 1391, also known as the pogroms of 1391, refers to a murderous wave of mass violence committed against the Jews of Spain by the Catholic populace in the crowns of Castile and Aragon in 1391. It was one of the most lethal outbreaks of violence against Jews in medieval Spain, and in medieval European history. Anti-Jewish violence then continued throughout the "Reconquista", culminating in the 1492 expulsion of the Jews from Spain. The first wave in 1391 marked the extreme of such violence.
Under duress, Jews began to convert en masse to Roman Catholicism across the Iberian Peninsula after the massacre, resulting in a substantial population of conversos known as Marranos. Catholics then began to accuse the conversos of secretly maintaining Jewish practices, and of thus undermining the newly united kingdom's nascent national identity. In 1492, the Catholic Monarchs of Spain Ferdinand and Isabella issued the Alhambra Decree, which ordered the expulsion of Jews who had not converted to Catholicism. The resulting diaspora came to be known as the Sephardic Jews.