Lung cancer in the context of Wheezing

On 11 March 2011, a major nuclear accident started at the Fukushima Daiichi Nuclear Power Plant in Ōkuma, Fukushima, Japan. The direct cause was the Tōhoku earthquake and tsunami, which resulted in electrical grid failure and damaged nearly all of the power plant's backup energy sources. The subsequent inability to sufficiently cool reactors after shutdown compromised containment and resulted in the release of radioactive contaminants into the surrounding environment. The accident was rated seven (the maximum severity) on the International Nuclear Event Scale by Nuclear and Industrial Safety Agency, following a report by the JNES (Japan Nuclear Energy Safety Organization). It is regarded as the worst nuclear incident since the Chernobyl disaster in 1986, which was also rated a seven on the International Nuclear Event Scale.

According to the United Nations Scientific Committee on the Effects of Atomic Radiation, "no adverse health effects among Fukushima residents have been documented that are directly attributable to radiation exposure from the Fukushima Daiichi nuclear plant accident". Insurance compensation was paid for one death from lung cancer, but this does not prove a causal relationship between radiation and the cancer. Six other persons have been reported as having developed cancer or leukemia. Two workers were hospitalized because of radiation burns, and several other people sustained physical injuries as a consequence of the accident.

Smoking cessation, usually called quitting smoking or stopping smoking, is the process of discontinuing tobacco smoking. Tobacco smoke contains nicotine, which is addictive and can cause dependence. As a result, nicotine withdrawal often makes the process of quitting difficult.

Smoking is the leading cause of preventable death and a global public health concern. Tobacco use leads most commonly to diseases affecting the heart and lungs, with smoking being a major risk factor for heart attacks, strokes, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), emphysema, and various types and subtypes of cancers (particularly lung cancer, cancers of the oropharynx, larynx, and mouth, esophageal and pancreatic cancer). Smoking cessation significantly reduces the risk of dying from smoking-related diseases. The risk of heart attack in a smoker decreases by 50% after one year of cessation. Similarly, the risk of lung cancer decreases by 50% in 10 years of cessation

Dichlorodiphenyldichloroethane (DDD) is an organochlorine insecticide that is slightly irritating to the skin. DDD is a metabolite of DDT. DDD is colorless and crystalline; it is closely related chemically and is similar in properties to DDT, but it is considered to be less toxic to animals than DDT. The molecular formula for DDD is (ClC₆H₄)₂CHCHCl₂ or C₁₄H₁₀Cl₄, whereas the formula for DDT is (ClC₆H₄)₂CHCCl₃ or C₁₄H₉Cl₅.

DDD is in the “Group B2” classification, meaning that it is a probable human carcinogen. This is based on an increased incidence of lung tumors in male and female mice, liver tumors in male mice, and thyroid tumors in male rats. A further basis is that DDD is similar to and is a metabolite of DDT, another probable human carcinogen.

Lifestyle diseases can be defined as the diseases linked to the manner in which a person lives their life. These diseases are non-communicable, and can be caused by lack of physical activity, unhealthy eating, alcohol, substance use disorders and smoking tobacco, which can lead to heart disease, stroke, obesity, type II diabetes and lung cancer. The diseases that appear to increase in frequency as countries become more industrialized and people live longer include Alzheimer's disease, arthritis, atherosclerosis, asthma, cancer, chronic liver disease or cirrhosis, chronic obstructive pulmonary disease, colitis, irritable bowel syndrome, type 2 diabetes, heart disease, hypertension, metabolic syndrome, chronic kidney failure, osteoporosis, PCOD, stroke, depression, obesity and vascular dementia.

Concerns were raised in 2011 that lifestyle diseases could soon have an impact on the workforce and the cost of health care. Treating these non-communicable diseases can be expensive. It can be critical for the patient's health to receive primary prevention and identify early symptoms of these non-communicable diseases. These lifestyle diseases are expected to increase throughout the years if people do not improve their lifestyle choices.

Respiratory diseases, or lung diseases, are pathological conditions affecting the organs and tissues that make gas exchange difficult in air-breathing animals. They include conditions of the respiratory tract including the trachea, bronchi, bronchioles, alveoli, pleurae, pleural cavity, the nerves and muscles of respiration. Respiratory diseases range from mild and self-limiting, such as the common cold, influenza, and pharyngitis to life-threatening diseases such as bacterial pneumonia, pulmonary embolism, tuberculosis, acute asthma, lung cancer, chronic obstructive pulmonary disease and severe acute respiratory syndromes, such as COVID-19. Respiratory diseases can be classified in many different ways, including by the organ or tissue involved, by the type and pattern of associated signs and symptoms, or by the cause of the disease.

The study of respiratory disease is known as pulmonology. A physician who specializes in respiratory disease is known as a pulmonologist, a chest medicine specialist, a respiratory medicine specialist, a respirologist or a thoracic medicine specialist.

Hemoptysis or haemoptysis is the discharge of blood or blood-stained mucus through the mouth coming from the bronchi, larynx, trachea, or lungs. In other words, it is the airway bleeding, and does not necessarily involve coughing. This can occur with lung cancer, infections such as tuberculosis, bronchitis, or pneumonia, and certain cardiovascular conditions. Hemoptysis is considered massive at 300 mL (11 imp fl oz; 10 US fl oz). In such cases, there are always severe injuries. The primary danger comes from choking, rather than blood loss.

Asbestos (/æsˈbɛstəs, æz-, -tɒs/ ass-BES-təs, az-, -⁠toss) is a group of naturally occurring, toxic, carcinogenic and fibrous silicate minerals. There are six types, all of which are composed of long and thin fibrous crystals, each fibre (particulate with length substantially greater than width) being composed of many microscopic "fibrils" that can be released into the atmosphere by abrasion and other processes. Inhalation of asbestos fibres can lead to various dangerous lung conditions, including mesothelioma, asbestosis, and lung cancer. As a result of these health effects, asbestos is considered a serious health and safety hazard.

Archaeological studies have found evidence of asbestos being used as far back as the Stone Age to strengthen ceramic pots, but large-scale mining began at the end of the 19th century when manufacturers and builders began using asbestos for its desirable physical properties. Asbestos is an excellent thermal and electrical insulator, and is highly fire-resistant, so for much of the 20th century, it was very commonly used around the world as a building material (particularly for its fire-retardant properties), until its adverse effects on human health were more widely recognized and acknowledged in the 1970s. Many buildings constructed before the 1980s contain asbestos.

Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. It is administered by intravenous injection. There is also an albumin-bound formulation.

Common side effects include hair loss, bone marrow suppression, numbness, allergic reactions, muscle pains, and diarrhea. Other side effects include heart problems, increased risk of infection, and lung inflammation. There are concerns that use during pregnancy may cause birth defects. Paclitaxel is in the taxane family of medications. It works by interference with the normal function of microtubules during cell division.

Pleurisy, also known as pleuritis, is inflammation of the membranes that surround the lungs and line the chest cavity (pleurae). This can result in a sharp chest pain while breathing. Occasionally the pain may be a constant dull ache. Other symptoms may include shortness of breath, cough, fever, and weight loss, depending on the underlying cause.

Pleurisy can be caused by a variety of conditions, including viral or bacterial infections, autoimmune disorders, and pulmonary embolism. The most common cause is a viral infection. Other causes include bacterial infection, pneumonia, pulmonary embolism, autoimmune disorders, lung cancer, following heart surgery, pancreatitis and asbestosis. Occasionally the cause remains unknown. The underlying mechanism involves the rubbing together of the pleurae instead of smooth gliding. Other conditions that can produce similar symptoms include pericarditis, heart attack, cholecystitis, pulmonary embolism, and pneumothorax. Diagnostic testing may include a chest X-ray, electrocardiogram (ECG), and blood tests.

Women's health is an example of population health, where health is defined by the World Health Organization (WHO) as "a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity". Often treated as simply women's reproductive health, many groups argue for a broader definition pertaining to the overall health of women, better expressed as "The health of women". These differences are further exacerbated in developing countries where women, whose health includes both their risks and experiences, are further disadvantaged.

While the rates of the leading causes of death, cardiovascular disease, cancer and lung disease, are similar in women and men, women have different experiences. Lung cancer has overtaken all other types of cancer as the leading cause of cancer related death in women, followed by breast cancer, colorectal, ovarian, uterine and cervical cancers. While smoking is the major cause of lung cancer, amongst nonsmoking women the risk of developing cancer is three times greater than among nonsmoking men. Despite this, breast cancer remains the most common cancer in women in developed countries, and is one of the major chronic diseases of women, while cervical cancer remains one of the most common cancers in developing countries, associated with human papilloma virus (HPV), a sexually transmitted infection. HPV vaccine together with screening offers the promise of controlling these diseases. Other important health issues for women include cardiovascular disease, depression, dementia, osteoporosis and anemia.

A primary tumor is a tumor growing at the anatomical site where tumor progression began and proceeded to yield a cancerous mass. Most solid cancers develop at their primary site but may then go on to metastasize or spread to other parts of the body. These further tumors are secondary tumors.

Most cancers continue to be called after their primary site, as in breast cancer or lung cancer for example, even after they have spread to other parts of the body. Cancer of unknown primary origin is cancer that is determined to be at the metastatic stage, but a primary tumor cannot be identified.

Pulmonary fibrosis is a condition in which the lungs become scarred over time. Symptoms include shortness of breath, a dry cough, feeling tired, weight loss, and nail clubbing. Complications may include pulmonary hypertension, respiratory failure, pneumothorax, and lung cancer.

Causes include environmental pollution, certain medications, connective tissue diseases, infections, and interstitial lung diseases. But in most cases the cause is unknown (idiopathic pulmonary fibrosis). Diagnosis may be based on symptoms, medical imaging, lung biopsy, and lung function tests.

A bone tumor is an abnormal growth of tissue in bone, traditionally classified as noncancerous (benign) or cancerous (malignant). Cancerous bone tumors usually originate from a cancer in another part of the body such as from lung, breast, thyroid, kidney and prostate. There may be a lump, pain, or neurological signs from pressure. A bone tumor might present with a pathologic fracture. Other symptoms may include fatigue, fever, weight loss, anemia and nausea. Sometimes there are no symptoms and the tumour is found when investigating another problem.

Diagnosis is generally by X-ray and other radiological tests such as CT scan, MRI, PET scan and bone scintigraphy. Blood tests might include a complete blood count, inflammatory markers, serum electrophoresis, PSA, kidney function and liver function. Urine may be tested for Bence Jones protein. For confirmation of diagnosis, a biopsy for histological evaluation might be required.

On 11 March 2011, a major nuclear accident started at the Fukushima Daiichi Nuclear Power Plant in Ōkuma, Fukushima, Japan. The direct cause was the Tōhoku earthquake and tsunami, which resulted in electrical grid failure and damaged nearly all of the power plant's backup energy sources. The subsequent inability to sufficiently cool reactors after shutdown compromised containment and resulted in the release of radioactive contaminants into the surrounding environment. The accident was rated seven (the maximum severity) on the International Nuclear Event Scale by Nuclear and Industrial Safety Agency, following a report by the JNES (Japan Nuclear Energy Safety Organization). It is regarded as the worst nuclear incident since the Chernobyl disaster in 1986, which is the only other incident rated seven on the International Nuclear Event Scale.

According to the United Nations Scientific Committee on the Effects of Atomic Radiation, "no adverse health effects among Fukushima residents have been documented that are directly attributable to radiation exposure from the Fukushima Daiichi nuclear plant accident". Insurance compensation was paid for one death from lung cancer, but this does not prove a causal relationship between radiation and the cancer. Six other persons have been reported as having developed cancer or leukemia. Two workers were hospitalized because of radiation burns, and several other people sustained physical injuries as a consequence of the accident.

The Kingston Fossil Plant Spill was an environmental and industrial disaster that occurred on December 22, 2008, when a dike ruptured at a coal ash pond at the Tennessee Valley Authority's Kingston Fossil Plant in Roane County, Tennessee, releasing 1.1 billion US gallons (4.2 million cubic metres) of coal fly ash slurry. The coal-fired power plant, located across the Clinch River from the city of Kingston, used a series of ponds to store and dewater the fly ash, a byproduct of coal combustion. The spill released a slurry of fly ash and water which traveled across the Emory River and its Swan Pond embayment onto the opposite shore, covering up to 300 acres (1.2 km) of the surrounding land. The spill damaged multiple homes and flowed into nearby waterways including the Emory River and Clinch River, both tributaries of the Tennessee River. It was the largest industrial spill in United States history.

The initial spill, which resulted in millions of dollars' worth of property damages and rendered many properties uninhabitable, cost TVA more than $1 billion to clean up and was declared complete in 2015. TVA was found liable for the spill in August 2012 by the U.S. District Court for the Eastern District of Tennessee. The initial spill resulted in no injuries or deaths, but several of the employees of an engineering firm hired by TVA to clean up the spill developed illnesses, including brain cancer, lung cancer, and leukemia, as a result of exposure to the toxic coal ash, and more than 30 had died within 10 years of the spill. In November 2018, a federal jury ruled that the contractor did not properly inform the workers about the dangers of exposure to coal ash and had failed to provide them with necessary personal protective equipment. After rejecting multiple offers, workers reached a settlement with the contractor in May 2023.

Tremolite is a member of the amphibole group of silicate minerals with composition Ca₂(Mg_5.0-4.5Fe_0.0-0.5)Si₈O₂₂(OH)₂. Tremolite forms by metamorphism of sediments rich in dolomite and quartz, and occurs in two distinct forms, crystals and fibers. Tremolite forms a series with actinolite and ferro-actinolite. Pure magnesium tremolite is creamy-white, but the color grades to dark green with increasing iron content. It has a hardness on Mohs scale of 5 to 6. Nephrite, one of the two minerals known as the gemstone jade, is a green crystalline variety of tremolite.

The fibrous form of tremolite is one of the six recognised types of asbestos. Inhaling asbestiform tremolite can lead to asbestosis, lung cancer and both pleural and malignant mesothelioma. Fibrous tremolite is sometimes found as a contaminant in vermiculite, chrysotile (itself a type of asbestos), and talc.