Interstate 10 in Texas in the context of "U.S. Highway 290 (Texas)"

Interstate 5 (I-5) is a major north–south route of the Interstate Highway System in the United States, running largely parallel to the Pacific Coast between the Mexican border and the Canadian border. The segment of I-5 in California runs across the length of the state from the Mexican border at the San Ysidro Port of Entry in the San Ysidro neighborhood of San Diego to the Oregon state line south of the Medford-Ashland metropolitan area. It is the longest interstate in California at 796.77 miles (1,282.28 km), and accounts for more than half of I-5's total length of 1,381.29 miles (2,222.97 km). It is also the second longest stretch of Interstate Highway (and the longest for a north-south Interstate) with a single designation within a single state after I-10 in Texas.

It is the more important and most-used of the two major north–south routes on the Pacific Coast, the other being U.S. Route 101 (US 101), which is primarily coastal. I-5 links the major California cities of San Diego, Santa Ana, Los Angeles, Stockton, Sacramento, and Redding. The San Francisco Bay Area is about 80 miles (130 km) west of the highway.

Downtown is the largest central business district in the city of Houston and the largest in the state of Texas, located near the geographic center of the metropolitan area at the confluence of Interstate 10, Interstate 45, and Interstate 69. The 1.84-square-mile (4.8 km) district, enclosed by the aforementioned highways, contains the original townsite of Houston at the confluence of Buffalo Bayou and White Oak Bayou, a point known as Allen's Landing. Downtown has been the city's preeminent commercial district since its founding in 1836.

Today home to nine Fortune 500 corporations, Downtown contains 50 million square feet (4,600,000 m) of office space and is the workplace of 150,000 employees. Downtown is also a major destination for entertainment and recreation. Nine major performing arts organizations are located within the 13,000-seat Theater District at prominent venues including Alley Theatre, Hobby Center for the Performing Arts, Jones Hall, and the Wortham Theater Center. Two major professional sports venues, Daikin Park and the Toyota Center, are home to the Houston Astros and Houston Rockets, respectively. Discovery Green, an urban park located on the east side of the district adjacent to the George R. Brown Convention Center, anchors the city's convention district.

Interstate 20 (I-20) is a major east–west Interstate Highway in Texas, running east from a junction with I-10 east of Kent, Texas, through the Dallas–Fort Worth metroplex to the Louisiana state line near Waskom, Texas. The original distance of I-20 was 647 miles (1,041 km) from I-10 to the Louisiana state line, reduced to the current distance of 636 miles (1,024 km) with the rerouting of I-20 in the 1980s and 1990s. I-20 is known as the Ronald Reagan Memorial Highway within the Dallas–Fort Worth metroplex.

Beltway 8 (BW8), the Sam Houston Parkway, along with the Sam Houston Tollway, is an 88-mile (142 km) beltway around the city of Houston, Texas, United States, lying entirely within Harris County.

Beltway 8, a state highway maintained by the Texas Department of Transportation (TxDOT), runs mostly along the frontage roads of the tollway, only using the main lanes where they are free: between Interstate 45 (I-45, North Freeway) and Interstate 69/US Highway 59 (I-69/US 59, Eastex Freeway); and between US 90 (Crosby Freeway) and I-10 (Baytown-East Freeway). The main lanes elsewhere are the Sam Houston Tollway, a toll road owned and operated by the Harris County Toll Road Authority (HCTRA). East of Houston, the tollway crosses the Houston Ship Channel on the Sam Houston Ship Channel Bridge, a toll bridge; this forms a gap in Beltway 8 between I-10 (Baytown-East Freeway) and State Highway 225 (SH 225, La Porte Freeway).