Interstate Highway in the context of "Interstate 20 in Texas"

Interstate 95 (I-95) is the main north–south Interstate Highway on the East Coast of the United States, running from U.S. Route 1 (US 1) in Miami, Florida, north to the Houlton–Woodstock Border Crossing between Maine and the Canadian province of New Brunswick. The highway largely parallels the Atlantic coast and US 1, except for the portion between Savannah, Georgia, and Washington, D.C., and the portion between Portland and Houlton in Maine, both of which follow a more direct inland route.

I-95 serves as the principal road link between the major cities of the Eastern Seaboard. Major metropolitan areas along its route include Miami, Jacksonville, and Savannah in the Southeast; Richmond, Washington, Baltimore, Wilmington–Philadelphia, Newark, and New York City in the Mid-Atlantic; and New Haven, Providence, Boston, and Portland in New England. The Charleston, Wilmington, and Norfolk–Virginia Beach metropolitan areas, the three major coastal metros bypassed by the highway's inland portion, are connected to I-95 by I-26, I-40, and I-64, respectively.

Interstate 45 (I-45) is a major Interstate Highway located entirely within the U.S. state of Texas. While most primary Interstate routes which have numbers ending in "5" are cross-country north–south routes, I-45 is comparatively short, with the entire route located within Texas. Additionally, it has the shortest length of all the primary Interstates divisible by 5, and is the only Interstate Highway of such. It connects the cities of Dallas and Houston, continuing southeast from Houston to Galveston over the Galveston Causeway to the Gulf of Mexico.

I-45 replaced U.S. Highway 75 (US 75) over its entire length, although portions of US 75 remained parallel to I-45 until its elimination south of Downtown Dallas in 1987. At the south end of I-45, State Highway 87 (SH 87, formerly part of US 75) continues into downtown Galveston. The north end is at I-30 in Downtown Dallas, where US 75 used the Good-Latimer Expressway. A short continuation, known by traffic reporters as the I-45 overhead, signed as part of US 75 and also part of unsigned I-345, continues north to the merge with the current end of US 75. Traffic can use Spur 366 (better known locally as the Woodall Rodgers Freeway) to connect to I-35E at the north end of I-345.

Interstate 35E (I-35E), a north–south Interstate Highway, is the eastern half of I-35, where it splits to serve the Dallas–Fort Worth metropolitan area. I-35 splits into two branch routes, I-35W and I-35E, at Hillsboro. I-35E travels north for 97 miles (156 km), maintaining I-35's sequence of exit numbers. It travels through Dallas before rejoining with I-35W to reform I-35 in Denton.

During the early years of the Interstate Highway System, branching Interstates with directional suffixes, such as N, S, E, and W, were common nationwide. On every other Interstate nationwide, these directional suffixes have been phased out by redesignating the suffixed route numbers with a loop or spur route number designation (such as I-270 in Maryland, which was once I-70S) or, in some cases, were assigned a different route number (such as I-76, which was once I-80S). In the case of I-35 in the Dallas–Fort Worth area, since neither branch is clearly the main route and both branches return to a unified Interstate beyond the cities of Dallas and Fort Worth, the American Association of State Highway and Transportation Officials has allowed the suffixes of E and W in Texas to remain to the present day. I-35 also splits into I-35E and I-35W in Minneapolis–St. Paul, Minnesota, for similar reasons as the I-35 split in the Dallas–Fort Worth area.

Interstate 30 (I-30) is a major Interstate Highway in the southern states of Texas and Arkansas in the United States. I-30 travels 366.76 miles (590.24 km) from I-20 west of Fort Worth, Texas, northeast via Dallas, and Texarkana, Texas, to I-40 in North Little Rock, Arkansas. The highway parallels U.S. Route 67 (US 67) except for the portion west of Downtown Dallas (which was once part of I-20). Between the termini, I-30 has interchanges with I-35W, I-35E, and I-45. I-30 is known as the Tom Landry Freeway between I-35W and I-35E, within the core of the Dallas–Fort Worth metroplex.

Interstate 70 (I-70) is a transcontinental Interstate Highway in the United States, stretching from Cove Fort, Utah, to Baltimore, Maryland. In Colorado, the highway traverses an east–west route across the center of the state. In western Colorado, the highway connects the metropolitan areas of Grand Junction and Denver via a route through the Rocky Mountains. In eastern Colorado, the highway crosses the Great Plains, connecting Denver with metropolitan areas in Kansas and Missouri. Bicycles and other non-motorized vehicles, normally prohibited on Interstate Highways, are allowed on those stretches of I-70 in the Rockies where no other through route exists.

The United States Department of Transportation (USDOT) lists the construction of I-70 among the engineering marvels undertaken in the Interstate Highway System and cites four major accomplishments: the section through the Dakota Hogback, Eisenhower Tunnel, Vail Pass, and Glenwood Canyon. The Eisenhower Tunnel, with a maximum elevation of 11,158 feet (3,401 m) and length of 1.7 miles (2.7 km), is the longest mountain tunnel and highest point along the Interstate Highway System. The portion through Glenwood Canyon was completed on October 14, 1992. This was one of the final pieces of the Interstate Highway System to open to traffic and is one of the most expensive rural highways per mile built in the country. The Colorado Department of Transportation (CDOT) earned the 1993 Outstanding Civil Engineering Achievement Award from the American Society of Civil Engineers for the completion of I-70 through the canyon.

Interstate 20 (I‑20) is a major east–west Interstate Highway in the Southern United States. I-20 runs 1,539 miles (2,477 km) beginning at an interchange with I-10 in Reeves County, Texas, 40 miles (64 km) east of Van Horn, Texas, and ending at an interchange with I-95 in Florence, South Carolina. Between Texas and South Carolina, I-20 runs through northern Louisiana, Mississippi, Alabama, and Georgia. The major cities that I-20 connects to include Dallas-Fort Worth, Texas; Shreveport, Louisiana; Jackson, Mississippi; Birmingham, Alabama; Atlanta, Georgia; and Columbia, South Carolina.

From its terminus at I-95, the highway continues about two miles (3.2 km) eastward into the city of Florence as I-20 Business (I-20 Bus.).

Interstate 64 (I-64) is an east–west Interstate Highway in the Eastern United States. Its western terminus is at I-70, U.S. Route 40 (US 40), and US 61 in Wentzville, Missouri. Its eastern terminus is at the Bowers Hill Interchange with I-264 and I-664 at Bower's Hill in Chesapeake, Virginia. I-64 connects Greater St. Louis, the Louisville metropolitan area, the Lexington–Fayette metropolitan area, the Charleston, WV metropolitan area, the Greater Richmond Region, and Hampton Roads.

Interstate 66 (I-66) is a 76.32 mile east–west interstate highway in the eastern United States. The highway runs from an interchange with I-81 near Middletown, Virginia, on its western end to an interchange with U.S. Route 29 (US 29) in Washington, D.C., at the eastern terminus. The route parallels State Route 55 (SR 55) from its western terminus at I-81 to Gainesville, and US 29 from Gainesville to its eastern terminus in Washington. I-66 is unrelated to US 66, which was located in the Midwest-West region of the United States.

The E Street Expressway is a spur from I-66 into the Foggy Bottom neighborhood of Washington, D.C.

Interstate 55 (I-55) is a major north–south Interstate Highway in the US state of Illinois that connects St. Louis, Missouri, to the Chicago metropolitan area. It enters the state from Missouri near East St. Louis, Illinois, and runs to U.S. Route 41 (US 41, Lake Shore Drive) near Downtown Chicago, where the highway ends, a distance of 294.38 miles (473.76 km). The road also runs through the Illinois cities of Springfield, Bloomington, and Joliet. The section in Cook County is officially named the Stevenson Expressway for the governor, and in DuPage County it's officially named the Joliet Freeway or the Will Rogers Freeway for the humorist. The section from the south suburbs to the area near Pontiac is officially named the Barack Obama Presidential Expressway after the president, who launched his political career from Illinois.