Daniel Boone in the context of "Boone County, Missouri"

American pioneers, were European Americans, African Americans, Hispanic/Latino Americans, and Asian Americans, who settled the Western United States. The majority of the European-American and African-American settlers had marched west from the British Thirteen Colonies and later the United States of America, to settle and develop areas of the nation within the continent of North America. Others migrated north from Latin America and east from Asia.

The pioneer concept and ethos greatly predate the settlement of the Western United States, with which they are commonly associated, and many places now considered "East" were settled by pioneers from even further east. For example, Daniel Boone, a key figure in U.S. history, settled in Kentucky, when that "Dark and Bloody Ground" was still undeveloped.

U.S. Route 25E (US 25E) is the eastern branch of US 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin. The highway, however, continues as US 25E for roughly two miles (3.2 km) until it joins Interstate 75 (I-75) in the Laurel County community of North Corbin at exit 29. The highway serves the Appalachia regions of Kentucky's Cumberland Plateau and the Ridge-and-Valley section of East Tennessee, including the urbanized areas of Corbin and Middlesboro in Kentucky and Morristown in Tennessee.

US 25E follows the original pathway of early U.S. pioneer Daniel Boone's Wilderness Road, which contributed to the increased settlement of Appalachia given its access through the rugged Cumberland Gap. By 1815, the route became the first state-funded road in Tennessee and, in 1923, unsigned State Route 32 (SR 32) in the Tennessee State Route System in its statewide entirety. It would be recognized as part of the Dixie Highway, one of the earliest federal auto trails, in 1915. The route was officially established as US 25E with the creation of the U.S. Numbered Highway System in 1926.

Charleston (/ˈtʃɑːrlstən/) is the capital and most populous city of the U.S. state of West Virginia. Located at the confluence of the Elk and Kanawha rivers, it is the county seat of Kanawha County. The population was 48,864 at the 2020 census (estimated at 46,482 in 2024). The Charleston metropolitan area has approximately 203,000 residents.

Charleston was established in the late 18th century and formally incorporated in 1794, with the trustees being Daniel Boone, Leonard Morris, and William Morris. The city gained prominence in the 19th century with the growth of the salt industry and later expanded due to coal mining and the first natural gas well. After West Virginia separated from Virginia, Charleston became the permanent state capital in 1885. Its economy and infrastructure further evolved in the 20th century with the rise of chemical manufacturing and public sector employment.

The Cumberland Gap is a pass in the eastern United States through the long ridge of the Cumberland Mountains, within the Appalachian Mountains and near the tripoint of Kentucky, Virginia, and Tennessee. At an elevation of 1,631 feet (497 m) above sea level, it is famous in American colonial history for its role as a key passageway through the lower central Appalachians.

Long used by Native American nations, the Cumberland Gap was brought to the attention of settlers in 1750 by Thomas Walker, a Virginia physician and explorer. The path was used by a team of frontiersmen led by Daniel Boone, making it accessible to pioneers who used it to journey into the western frontiers of Kentucky and Tennessee. An important part of the Wilderness Road, it is now part of the Cumberland Gap National Historical Park.

The Wilderness Road was one of two principal routes used by colonial and early national era settlers to reach Kentucky from the East. Although this road goes through the Cumberland Gap into southern Kentucky and northern Tennessee, the other (more northern route) is sometimes called the "Cumberland Road" because it started in Fort Cumberland in Maryland. Despite Kentucky Senator Henry Clay's advocacy of this route early in the 19th century, the northern route was selected for the National Road, connecting near Washington, Pennsylvania into the Ohio Valley of northern Kentucky and Ohio.

In 1775, Daniel Boone blazed a trail for the Transylvania Company from Fort Chiswell in Virginia through the Cumberland Gap. It was later lengthened, following Indian trails, to reach the Falls of the Ohio at Louisville. The Wilderness Road was steep, rough and narrow. It could be traversed only on foot or horseback. By contrast, wagons could travel along the National Road route (originally the Braddock Road blazed by the competing Ohio Company and George Washington circa 1750), particularly after the improvements.

Callaway County is a county located in the U.S. state of Missouri. As of the 2020 United States census, the county's population was 44,283. Its county seat is Fulton. With a border formed by the Missouri River, the county was organized November 25, 1820, and named for Captain James Callaway, grandson of Daniel Boone. The county has been historically referred to as "The Kingdom of Callaway" after an incident in which some residents confronted Union troops during the U.S. Civil War.

Callaway County is part of the Jefferson City, Missouri, Metropolitan Statistical Area.

Marthasville is a city in Warren County, Missouri, United States. The population was 1,136 at the 2010 census. The Katy Trail, a 240-mile long bike path, passes through Marthasville.

The original graves of Daniel Boone and his wife were located near there. In 1845, Boone's remains were disinterred and moved to Kentucky for burial. Resentment in Missouri about the disinterment grew over the years, and a legend arose that Boone's remains never left Missouri.