Ayyubid Sultanate in the context of "Sultan of Egypt"

The Fourth Crusade (1202–1204) was a Latin Christian armed expedition called by Pope Innocent III. The stated intent of the expedition was to recapture the Muslim-controlled city of Jerusalem, by first defeating the powerful Egyptian Ayyubid Sultanate. However, a sequence of economic and political events culminated in the Crusader army's 1202 siege of Zara and the 1204 sack of Constantinople, rather than the conquest of Egypt as originally planned. This led to the partition of the Byzantine Empire by the Crusaders and their Venetian allies, leading to a period known as the Frankokratia ("Rule of the Franks" in Greek).

In 1201, the Republic of Venice contracted with the Crusader leaders to build a dedicated fleet to transport their invasion force. However, the leaders greatly overestimated the number of soldiers who would embark from Venice, since many sailed from other ports, and the army that appeared could not pay the contracted price. In lieu of payment, the Venetian Doge Enrico Dandolo proposed that the Crusaders back him in attacking the rebellious city of Zara (Zadar) on the eastern Adriatic coast. This led in November 1202 to the siege and sack of Zara, the first attack against a Catholic city by a Catholic Crusader army, despite Pope Innocent III's calls for the Crusaders not to attack fellow Christians. The city was then brought under Venetian control. When the Pope heard of this, he temporarily excommunicated the Crusader army.

Moses ben Maimon, commonly known as Maimonides and also referred to by the Hebrew acronym Rambam, was a Sephardic Jewish rabbi who is widely acknowledged as one of the most prolific and influential Torah scholars of the Middle Ages. Originally from Córdoba, where he was born on Passover Eve of 1135 or 1138, his family was exiled from Muslim-ruled Spain when they refused to convert to Islam shortly after the Almohad Caliphate conquered the Almoravid Caliphate in 1148. Over the course of the next two decades, Maimonides resided in Fez, Acre, Jerusalem, Alexandria, and Cairo before finally settling in Fustat between 1168 and 1171. During this period, he advanced his vocations and became renowned for his achievements as an astronomer, philosopher, and physician—even being appointed to serve as personal physician to Saladin of the Ayyubid Sultanate.

Most contemporary Jews as far as Iraq and Yemen greeted Maimonides' writings on halakha and Jewish ethics with acclaim and gratitude. Yet, while he rose to lead the Jewish community in Egypt, he also had vociferous critics, particularly in Spain. He continued to live in Fustat until his death in 1204 and is said to have been buried in Tiberias. Accordingly, the Tomb of Maimonides in Tiberias holds importance as a Jewish pilgrimage site.

The region of Palestine is part of the wider region of the Levant, which represents the land bridge between Africa and Eurasia. The areas of the Levant traditionally serve as the "crossroads of Western Asia, the Eastern Mediterranean, and Northeast Africa", and in tectonic terms are located in the "northwest of the Arabian Plate". Palestine itself was among the earliest regions to see human habitation, agricultural communities and civilization. Because of its location, it has historically been seen as a crossroads for religion, culture, commerce, and politics. In the Bronze Age, the Canaanites established city-states influenced by surrounding civilizations, among them Egypt, which ruled the area in the Late Bronze Age. During the Iron Age, two related Israelite kingdoms, Israel and Judah, controlled much of Palestine, while the Philistines occupied its southern coast. The Assyrians conquered the region in the 8th century BCE, then the Babylonians c. 601 BCE, followed by the Persian Achaemenid Empire that conquered the Babylonian Empire in 539 BCE. Alexander the Great conquered the Persian Empire in the late 330s BCE, beginning Hellenization.

In the late 2nd-century BCE Maccabean Revolt, the Jewish Hasmonean Kingdom conquered most of Palestine; the kingdom subsequently became a vassal of Rome, which annexed it in 63 BCE. Roman Judea was troubled by Jewish revolts in 66 CE, so Rome destroyed Jerusalem and the Second Jewish Temple in 70 CE. In the 4th century, as the Roman Empire adopted Christianity, Palestine became a center for the religion, attracting pilgrims, monks and scholars. Following Muslim conquest of the Levant in 636–641, ruling dynasties succeeded each other: the Rashiduns; Umayyads; Abbasids; the semi-independent Tulunids and Ikhshidids; Fatimids; and the Seljuks. In 1099, the First Crusade resulted in Crusaders establishing of the Kingdom of Jerusalem, which was reconquered by the Ayyubid Sultanate in 1187. Following the invasion of the Mongol Empire in the late 1250s, the Egyptian Mamluks reunified Palestine under its control, before the region was conquered by the Ottoman Empire in 1516, being ruled as Ottoman Syria until the 20th century largely without dispute.