Western North Carolina (often abbreviated as WNC) is the region of North Carolina which includes the Appalachian Mountains; it is often known geographically as the state's Mountain Region. It contains the highest mountains in the Eastern United States, with 125 peaks rising to over 5,000 feet (1,500 meters) in elevation. Mount Mitchell at 6,684 feet (2,037 meters), is the highest peak of the Appalachian Mountains and mainland eastern North America. The population of the 23 most commonly associated counties for the region, as measured by the 2020 U.S. census, is 1,149,405. The region accounts for approximately 11% of North Carolina's total population.
Located east of the Tennessee state line and west of the Piedmont, Western North Carolina contains few major urban centers. Asheville, located in the region's center, is the area's largest city and most prominent commercial hub. The Foothills region of the state is loosely defined as the area along Western North Carolina's eastern boundary; this region consists of a transitional terrain of hills between the Appalachians and Piedmont Plateau of central North Carolina.