Upstate South Carolina in the context of "Bible Belt"

South Carolina (/ˌkærəˈlaɪnə/ KARR-ə-LY-nə) is a state in the Southeastern, South Atlantic and Deep South regions of the United States. It borders North Carolina to the north and northeast, the Atlantic Ocean to the southeast, and Georgia to the west and south across the Savannah River. Along with North Carolina, it makes up the Carolinas region of the East Coast. South Carolina is the 11th-smallest and 23rd-most populous U.S. state with a recorded population of 5,118,425 according to the 2020 census. In 2019, its GDP was $213.45 billion. South Carolina is composed of 46 counties. The capital is Columbia with a population of 136,632 in 2020; while its most populous city is Charleston with a 2020 population of 150,227. The Greenville-Spartanburg-Anderson, SC Combined Statistical Area is the most populous combined metropolitan area in the state, with an estimated 2023 population of 1,590,636.

South Carolina was named in honor of King Charles I of England, who first formed the English colony, with Carolus being Latin for "Charles". In 1712 the Province of South Carolina was formed. One of the original Thirteen Colonies, South Carolina became a royal colony in 1719. During the American Revolutionary War, South Carolina was the site of major activity among the American colonies, with more than 200 battles and skirmishes fought within the state. South Carolina became the eighth state to ratify the U.S. Constitution on May 23, 1788. A slave state, it was the first state to vote in favor of secession from the Union on December 20, 1860. After the Civil War ended, the state was readmitted to the Union on July 9, 1868.

The U.S. State of South Carolina currently has 20 statistical areas that have been delineated by the Office of Management and Budget (OMB). On July 21, 2023, the OMB delineated four combined statistical areas, ten metropolitan statistical areas, and six micropolitan statistical areas in South Carolina. As of 2023, the largest of these is the Greenville-Spartanburg-Anderson, SC CSA, comprising the area around Greenville in the state's Upcountry.

The Office of Management and Budget (OMB) has designated more than 1,000 statistical areas for the United States and Puerto Rico. These statistical areas are important geographic delineations of population clusters used by the OMB, the United States Census Bureau, planning organizations, and federal, state, and local government entities.