U.S. Route 2 or U.S. Highway 2 (US 2) is an east–west United States Numbered Highway spanning 2,571 miles (4,138 km) across the northern continental United States. US 2 consists of two segments on either side of a portion of Canada. Unlike some routes, which are disconnected into segments because of encroaching Interstate Highways, the two portions of US 2 were designed to be separate in the original 1926 highway plan.
The western segment of US 2 begins at an interchange with Interstate 5 (I-5) and State Route 529 (Maple Street) in Everett, Washington, and ends at I-75 in St. Ignace, Michigan. The eastern segment of US 2 begins at US 11 in Rouses Point, New York, and ends at I-95 in Houlton, Maine.