Interstate 75 in the context of "U.S. Route 2"

Michigan (/ˈmɪʃɪɡən/ MISH-ig-ən) is a peninsular state in the Great Lakes region of the Upper Midwestern United States. It shares water and land boundaries with Minnesota to the northwest, Wisconsin to the west, Indiana and Illinois to the southwest, Ohio to the southeast, and the Canadian province of Ontario to the east, northeast and north. With a population of 10.14 million and an area of 96,716 sq mi (250,490 km), Michigan is the tenth-largest state by population, the 11th-largest by area, and the largest by total area east of the Mississippi River. The state capital is Lansing, while its most populous city is Detroit. The Metro Detroit region in Southeast Michigan is among the nation's most populous and largest metropolitan economies. Other important metropolitan areas include Grand Rapids, Flint, Ann Arbor, Kalamazoo, the Tri-Cities, and Muskegon.

Michigan consists of two peninsulas: the heavily forested Upper Peninsula (commonly called "the U.P."), which juts eastward from northern Wisconsin, and the more populated Lower Peninsula, stretching north from Ohio and Indiana. The peninsulas are separated by the Straits of Mackinac, which connects Lake Michigan and Lake Huron, and are linked by the 5-mile-long Mackinac Bridge along Interstate 75. Bordering four of the five Great Lakes and Lake St. Clair, Michigan has the longest freshwater coastline of any U.S. political subdivision, measuring 3,288 miles. The state ranks second behind Alaska in water coverage by square miles and first in percentage, with approximately 42%, and it also contains 64,980 inland lakes and ponds.

Interstate 26 (I-26) is a main route of the Interstate Highway System in the Southeastern United States. Nominally east–west, as indicated by its even number, I-26 runs from the junction of US Route 11W (US 11W) and US 23 in Kingsport, Tennessee, generally southeastward to US 17 in Charleston, South Carolina. The portion from Mars Hill, North Carolina, east (compass south) to I-240 in Asheville, North Carolina, has signs indicating FUTURE I-26, because the highway does not yet meet all of the Interstate Highway standards.

Northward from Kingsport, US 23 continues to Portsmouth, Ohio, as Corridor B of the Appalachian Development Highway System, and beyond to Columbus, Ohio, as Corridor C. In conjunction with the Columbus–Toledo corridor in Ohio formed by I-75, US 23, and State Route 15 (SR 15), I-26 forms part of a mostly high-speed four-or-more-lane highway from the Great Lakes to the Atlantic Coast at Charleston, South Carolina.

Interstate 35 (I-35) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route. It stretches from Laredo, Texas, near the Mexican border to Duluth, Minnesota, at Minnesota State Highway 61 (MN 61, London Road) and 26th Avenue East. The highway splits into I-35E and I-35W in two separate places, the Dallas–Fort Worth metroplex in Texas and at the Minnesota twin cities of Minneapolis–Saint Paul.

At 1,568 miles (2,523 km), I-35 is the ninth-longest Interstate Highway following I-94, and it is the third-longest north–south Interstate Highway, following I-75 and I-95. Even though the route is generally considered to be a border-to-border highway, this highway does not directly connect to either international border. I-35's southern terminus is the traffic signal at Hidalgo Street in Laredo, Texas, just short of the Mexican border. Travelers going south can take one of two toll bridges across the Rio Grande and the border, either straight ahead onto the Juárez–Lincoln International Bridge, or via Business Interstate 35-A (Bus. I-35-A) through downtown Laredo into the Gateway to the Americas International Bridge. To the north, I-35 terminates in Duluth, Minnesota, with connections to Canada from the Interstate's terminus via MN 61 to Grand Portage, or north to the border at International Falls, Minnesota, via U.S. Route 53 (US 53) in Duluth.