Urubamba River in the context of "Machu Picchu"

The Apurímac River (Quechua: Apurimaq mayu IPA: [ˈapʊ ˈɾɪmaχ ˈmajʊ]; Spanish: río Apurímac, IPA: [ˈri.o apuˈɾimak]; from Quechua apu 'chief' and rimaq 'the one who speaks, oracle', thus 'the chief oracle') rises from glacial meltwater of the ridge of the Mismi, a 5,597-metre-high (18,363 ft) mountain in the Arequipa Province in the south-western mountain ranges of Peru, 10 km (6.2 mi) from the village Caylloma, and less than 160 km (99 mi) from the Pacific coast. It flows generally northwest past Cusco in narrow gorges with depths of up to 3,000 m (9,800 ft), almost twice as deep as the Grand Canyon, its course interrupted by falls and rapids. Of the six attempts to travel the full length of the Apurímac so far, only two have been successful.

After 730 kilometres (450 mi), the Apurímac joins the Mantaro River and becomes the Ene River, 440 m (1,440 ft) above sea level; then after joining the Perené River at 330 m (1,080 ft) above sea level, it becomes the Tambo River; when it joins the Urubamba at 280 m (920 ft) above sea level the river becomes the Ucayali, which is the main headstream of the Amazon. Sometimes the complete river from its source to its junction with the Ucayali, including the rivers Ene and Tambo, is called "Apurímac", with a total length of 1,070 km (660 mi).

Cusco or Cuzco (Latin American Spanish: [ˈkusko]; Quechua: Qosqo or Qusqu, both pronounced in Cuzco Quechua as [ˈqosqɔ]) is a city in southeastern Peru, near the Sacred Valley of the Andes mountain range, and the Huatanay and Urubamba rivers. It is the capital and largest city of the eponymous Cusco Province and Cusco Department. It has historically been one of the largest cultural, economic and political centers of Peru.

The city was originally founded in the 12th century as the capital of the Inca Empire. The region was conquered in the 16th-century by the Spanish and reestablished on 23 March 1524, with most of the city being constructed over monuments left from the Inca Empire. In 1983, Cusco was declared a World Heritage Site by UNESCO with the title "City of Cusco". It has become a major tourist destination, hosting over 2 million visitors a year and providing passage to numerous Incan ruins, such as Machu Picchu, one of the Seven modern wonders of the world and many others. The Constitution of Peru (1993) designates the city as the Historical Capital of Peru.

The Tambo River (Spanish: Río Tambo) is a Peruvian river on the eastern slopes of the Andes. The name only refers to a relatively short section of the waterbody; about 159 km (99 mi) long. It starts at the confluence of the Ene and Perené Rivers at the town of Puerto Prado. From here the Tambo flows 70 km (43 mi) in an easterly direction and then turns north. When merging with the Urubamba River at the town of Atalaya, it becomes the Ucayali River.

The Tambo is part of the headwaters of the Amazon River whose origin is the Mantaro River at Cordilerra Ruminator Cruz.