Sacred Valley in the context of "Machu Picchu"

Cusco or Cuzco (Latin American Spanish: [ˈkusko]; Quechua: Qosqo or Qusqu, both pronounced in Cuzco Quechua as [ˈqosqɔ]) is a city in southeastern Peru, near the Sacred Valley of the Andes mountain range, and the Huatanay and Urubamba rivers. It is the capital and largest city of the eponymous Cusco Province and Cusco Department. It has historically been one of the largest cultural, economic and political centers of Peru.

The city was originally founded in the 12th century as the capital of the Inca Empire. The region was conquered in the 16th-century by the Spanish and reestablished on 23 March 1524, with most of the city being constructed over monuments left from the Inca Empire. In 1983, Cusco was declared a World Heritage Site by UNESCO with the title "City of Cusco". It has become a major tourist destination, hosting over 2 million visitors a year and providing passage to numerous Incan ruins, such as Machu Picchu, one of the Seven modern wonders of the world and many others. The Constitution of Peru (1993) designates the city as the Historical Capital of Peru.

The Incas were most notable for establishing the Inca Empire which was centered in modern-day Peru and Chile. It was about 4,000 kilometres (2,500 mi) from the northern to southern tip. The Inca Empire lasted from 1438 to 1533. It was the largest Empire in America throughout the Pre-Columbian era. The Inca state was originally founded by Manco Cápac in the early 1200s, and is known as the Kingdom of Cuzco. Under subsequent rulers, through strategic alliances and conquests, it expanded beyond Cusco and into the Sacred Valley. Their territory then rapidly grew under the 9th Sapa Inca (emperor), Pachacuti and his descendents.

Over the course of the Inca Empire, the Inca used conquest and peaceful assimilation to incorporate the territory of modern-day Peru, followed by a large portion of western South America, into their empire, centered on the Andean mountain range. However, shortly after the Inca Civil War, the last Sapa Inca of the Inca Empire, Atahualpa, was captured and killed on the orders of the conquistador Francisco Pizarro, marking the beginning of Spanish rule. The remnants of the empire retreated to the remote jungles of Vilcabamba and established the small Neo-Inca State, which was conquered by the Spanish in 1572.