Surxondaryo Region is a region (viloyat) of Uzbekistan, located in the extreme south-east of the country. Established on 6 March 1941, it borders on Qashqadaryo Region internally, and Turkmenistan, Afghanistan and Tajikistan externally, going anticlockwise from the north. It takes its name from the river Surxondaryo, that flows through the region. It covers an area of 20,100 km². The population is estimated at 2,743,201 (beginning of 2022 data), with 80% living in rural areas. According to official data, 83% of the population are Uzbeks and 12.5% Tajiks. The highest point of the Region and also of Uzbekistan is Khazrati Sulton peak reaching 4,643 m/15,233 ft in Gissar Range.
The regional capital is Termez with a population of about 200,000 (2024), and the second largest city is Denov (Denau) with 78,300 inhabitants (data for 2016). Other towns include Boysun, Jarqoʻrgʻon, Qumqoʻrgʻon, Shargʻun, Sherobod, Shoʻrchi, and Sariosiyo.