Small nucleolar RNA in the context of "Telomerase RNA component"

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⭐ Core Definition: Small nucleolar RNA

Small nucleolar RNAs (snoRNAs) are a class of non-coding small RNA molecules in the nucleolus that primarily guide chemical modifications of other RNAs, mainly ribosomal RNAs, transfer RNAs and small nuclear RNAs. There are two main classes of snoRNA, the C/D box snoRNAs, which are associated with methylation, and the H/ACA box snoRNAs, which are associated with pseudouridylation.SnoRNAs are commonly referred to as guide RNAs but should not be confused with the guide RNAs that direct RNA editing in trypanosomes or the guide RNAs (gRNAs) used by Cas9 for CRISPR gene editing.

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👉 Small nucleolar RNA in the context of Telomerase RNA component

Telomerase RNA component (TERC), also abbreviated TER or TR, is a non-coding RNA found in eukaryotes that is a component of the telomerase enzyme, which extends telomeres at the ends of linear chromosomes. TERC folds into a complex secondary structure which binds to and interacts with TERT, the protein component of telomerase, and serves as the RNA template for the reverse transcription reaction catalyzed by TERT. Telomerase RNAs differ greatly in length, sequence and structure between vertebrates, ciliates and yeasts, but they share a 5' pseudoknot structure close to the template sequence; vertebrate telomerase RNAs also share a 3' H/ACA snoRNA-like domain.

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Small nucleolar RNA in the context of ScaRNAs

Small Cajal body-specific RNAs (scaRNAs) are a class of small nucleolar RNAs (snoRNAs) that specifically localise to the Cajal body, a nuclear organelle (cellular sub-organelle) involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs or snurps). ScaRNAs guide the modification (methylation and pseudouridylation) of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.

The first scaRNA identified was U85. It is unlike typical snoRNAs in that it is a composite C/D box and H/ACA box snoRNAs and can guide both pseudouridylation and 2′-O-methylation. Not all scaRNAs are composite C/D and H/ACA box snoRNA and most scaRNAs are structurally and functionally indistinguishable from snoRNAs, directing ribosomal RNA (rRNA) modification in the nucleolus.

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LINKED FROM (PARENTS)
← ScaRNAs ← Telomerase RNA component
LINKS TO (CHILDREN)
RNA → Nucleolus → Ribosomal RNA → Transfer RNA → Small nuclear RNA → Methylation → Pseudouridylation → Guide RNA → RNA editing → Trypanosomes → CRISPR gene editing →