Skin cancer in the context of "Merkel cell polyomavirus"

Sunburn is a form of radiation burn that affects living tissue, such as skin, that results from an overexposure to ultraviolet (UV) radiation, usually from the Sun. Common symptoms in humans and other animals include red or reddish skin that is hot to the touch or painful, general fatigue, and mild dizziness. Other symptoms include blistering, peeling skin, swelling, itching, and nausea. Excessive UV radiation is the leading cause of (primarily) non-malignant skin tumors, which in extreme cases can be life-threatening. Sunburn is an inflammatory response in the tissue triggered by direct DNA damage by UV radiation. When the cells' DNA is overly damaged by UV radiation, type I cell-death is triggered and the tissue is replaced.

Sun protective measures like sunscreen and sun protective clothing are widely accepted to prevent sunburn and some types of skin cancer. Special populations, including children, are especially susceptible to sunburn and protective measures should be used to prevent damage.

Vitamin D is a group of structurally related, fat-soluble compounds responsible for increasing intestinal absorption of calcium and phosphate, along with numerous other biological functions. In humans, the most important compounds within this group are vitamin D₃ (cholecalciferol) and vitamin D₂ (ergocalciferol).

Unlike the other twelve vitamins, vitamin D is only conditionally essential, as with adequate skin exposure to the ultraviolet B (UVB) radiation component of sunlight there is synthesis of cholecalciferol in the lower layers of the skin's epidermis. Vitamin D can also be obtained through diet, food fortification and dietary supplements. For most people, skin synthesis contributes more than dietary sources. In the U.S., cow's milk and plant-based milk substitutes are fortified with vitamin D₃, as are many breakfast cereals. Government dietary recommendations typically assume that all of a person's vitamin D is taken by mouth, given the potential for insufficient sunlight exposure due to urban living, cultural choices for the amount of clothing worn when outdoors, and use of sunscreen because of concerns about safe levels of sunlight exposure, including the risk of skin cancer.

Exposure to ionizing radiation is known to increase the future incidence of cancer, particularly leukemia. The mechanism by which this occurs is well understood, but quantitative models predicting the level of risk remain controversial. The most widely accepted model posits that the incidence of cancers due to ionizing radiation increases linearly with effective radiation dose at a rate of 5.5% per sievert; if correct, natural background radiation is the most hazardous source of radiation to general public health, followed by medical imaging as a close second. Additionally, the vast majority of non-invasive cancers are non-melanoma skin cancers caused by ultraviolet radiation (which lies on the boundary between ionizing and non-ionizing radiation). Non-ionizing radio frequency radiation from mobile phones, electric power transmission, and other similar sources have been investigated as a possible carcinogen by the WHO's International Agency for Research on Cancer, but to date, no evidence of this has been observed.

Gene–environment interaction (or genotype–environment interaction or G×E) is when two different genotypes respond to environmental variation in different ways. A norm of reaction is a graph that shows the relationship between genes and environmental factors when phenotypic differences are continuous. They can help illustrate GxE interactions. When the norm of reaction is not parallel, as shown in the figure below, there is a gene by environment interaction. This indicates that each genotype responds to environmental variation in a different way. Environmental variation can be physical, chemical, biological, behavior patterns or life events.

Gene–environment interactions are studied to gain a better understanding of various phenomena. In genetic epidemiology, gene–environment interactions are useful for understanding some diseases. Sometimes, sensitivity to environmental risk factors for a disease are inherited rather than the disease itself being inherited. Individuals with different genotypes are affected differently by exposure to the same environmental factors, and thus gene–environment interactions can result in different disease phenotypes. For example, sunlight exposure has a stronger influence on skin cancer risk in fair-skinned humans than in individuals with darker skin.

Light skin is a human skin color that has a low level of eumelanin pigmentation as an adaptation to environments of low UV radiation.Due to migrations of people in recent centuries, light-skinned populations today are found all over the world. Light skin is most commonly found amongst the native populations of Europe, East Asia, West Asia, Central Asia, South Asia, Siberia, and North Africa as measured through skin reflectance. People with light skin pigmentation are often referred to as "white", but the majority of countries officially categorize people by ethnic or national origin and not by perceived skin tone. Furthermore, definitions and perceptions of "ethnicity" or "race" vary greatly from country to country.

Humans with light skin pigmentation have skin with low amounts of eumelanin, and possess fewer melanosomes than humans with dark skin pigmentation. Light skin provides better absorption qualities of ultraviolet radiation, which helps the body to synthesize higher amounts of vitamin D for bodily processes such as calcium development. On the other hand, light-skinned people who live near the equator, where there is abundant sunlight, are at an increased risk of folate depletion. As a consequence of folate depletion, they are at a higher risk of DNA damage, birth defects, and numerous types of cancers, especially skin cancer. Humans with darker skin who live further from the tropics may have lower vitamin D levels, which can also lead to health complications, both physical and mental, including miscarriage and a greater risk of developing schizophrenia. These two observations form the "vitamin D–folate hypothesis", which attempts to explain why populations that migrated away from the tropics into areas of low UV radiation evolved to have light skin pigmentation.

Sunscreen, also known as sunblock, sun lotion or sun cream, is a photoprotective topical product for the skin that helps protect against sunburn and prevent skin cancer. Sunscreens come as lotions, sprays, gels, foams (such as an expanded foam lotion or whipped lotion), sticks, powders and other topical products. Sunscreens are common supplements to clothing, particularly sunglasses, sunhats and special sun protective clothing, and other forms of photoprotection (such as umbrellas). Sunscreen is on the World Health Organization's List of Essential Medicines.

Sunscreen products may be classified according to the type of active ingredient(s) present in the formulation (inorganic compounds or organic molecules) as:

Exposure of skin to ultraviolet radiation from sunlight presents both positive and negative health effects. On the positive side, UV exposure enables the synthesis of vitamin D₃, which is essential for bone health and potentially plays a role in inhibiting certain cancers. While vitamin D can also be obtained through dietary supplements, UV exposure offers benefits such as enhanced subdermal nitric oxide production and improved endorphin levels, which are not achievable through supplementation alone. Additionally, exposure to visible light supports melatonin synthesis, maintains circadian rhythms, and reduces the risk of seasonal affective disorder.

However, UV radiation is also a mutagen and carcinogen for the skin, posing significant risks. Acute exposure can lead to painful sunburns and increase the likelihood of developing serious skin conditions later in life. Prolonged exposure is associated with the development of skin cancers, photoaging or premature skin aging, immune suppression, and eye diseases like cataracts.