Plasma protein in the context of "Complement system"

Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body.

Once a drug enters into systemic circulation by absorption or direct administration, it must be distributed into interstitial and intracellular fluids. Each organ or tissue can receive different doses of the drug and the drug can remain in the different organs or tissues for a varying amount of time. The distribution of a drug between tissues is dependent on vascular permeability, regional blood flow, cardiac output and perfusion rate of the tissue and the ability of the drug to bind tissue and plasma proteins and its lipid solubility. pH partition plays a major role as well. The drug is easily distributed in highly perfused organs such as the liver, heart and kidney. It is distributed in small quantities through less perfused tissues like muscle, fat and peripheral organs. The drug can be moved from the plasma to the tissue until the equilibrium is established (for unbound drug present in plasma).

Hemolymph or haemolymph is a body fluid that circulates inside arthropod bodies transporting nutrients and oxygen to tissues, comparable with the blood in vertebrates. It is composed of a plasma in which circulating immune cells called hemocytes are dispersed in addition to many plasma proteins (hemoproteins) and dissolved chemicals. It is the key component of the open circulatory system characteristic of arthropods such as insects, arachnids, myriopods and crustaceans. Some non-arthropod invertebrates such as molluscs and annelids also possess a similar hemolymphatic circulatory system.

In insects, the largest arthropod clade, the hemolymph mainly carries nutrients but not oxygen, which is supplied to the tissues separately by direct deep ventilation through an extensive tracheal system. In other arthropods, oxygen is dissolved into the hemolymph from gills, book lungs or across the cuticle and then distributed to the body tissues via the hemocoel.

Oncotic pressure, or colloid osmotic-pressure, is a type of osmotic pressure induced by the plasma proteins, notably albumin, in a blood vessel's plasma (or any other body fluid such as blood and lymph) that causes a pull on fluid back into the capillary.

It has an effect opposing both the hydrostatic blood pressure, which pushes water and small molecules out of the blood into the interstitial spaces at the arterial end of capillaries, and the interstitial colloidal osmotic pressure. These interacting factors determine the partitioning of extracellular water between the blood plasma and the extravascular space.