Mustang District is one of the eleven districts of Gandaki Province and one of seventy-seven districts of Nepal which was a Kingdom of Lo-Manthang that joined the Federation of Nepal in 2008 after abolition of the Shah dynasty. The district covers an area of 3,573 km (1,380 sq mi) and in 2021 had a population of 14,452. The headquarter is located at Jomsom. Mustang is the fifth largest district of Nepal in terms of area. The district is home to Muktinath Temple ('lord of liberation or moksha') and is a sacred place for Hindus and Buddhists.
The district is a part of Gandaki Province in northern Nepal, straddles the Himalayas and extends northward onto the Tibetan Plateau. The district is one of the remotest areas in Nepal and is second in terms of the sparsity of population. The elevation ranges from 1,372 to 8,167 meters (mt.Dhaulagiri, the 7th highest mountain in the world), with several peaks above 7,000 meters.