Lysergic acid diethylamide in the context of "Deliriant"

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⭐ Core Definition: Lysergic acid diethylamide

Lysergic acid diethylamide, commonly known as LSD (from German Lysergsäurediethylamid) and by the slang names acid and lucy, is a semisynthetic hallucinogenic drug derived from ergot, known for its powerful psychological effects and serotonergic activity. It was historically used in psychiatry and 1960s counterculture; it is currently legally restricted but experiencing renewed scientific interest and increasing use.

When taken orally, LSD has an onset of action within 0.4 to 1.0 hours (range: 0.1–1.8 hours) and a duration of effect lasting 7 to 12 hours (range: 4–22 hours). It is commonly administered via tabs of blotter paper. LSD is extremely potent, with noticeable effects at doses as low as 20 micrograms and is sometimes taken in much smaller amounts for microdosing. Despite widespread use, no fatal human overdoses have been documented. LSD is mainly used recreationally or for spiritual purposes. LSD can cause mystical experiences. LSD exerts its effects primarily through high-affinity binding to several serotonin receptors, especially 5-HT2A, and to a lesser extent dopaminergic and adrenergic receptors. LSD reduces oscillatory power in the brain's default mode network and flattens brain hierarchy. At higher doses, it can induce visual and auditory hallucinations, ego dissolution, and anxiety. LSD use can cause adverse psychological effects such as paranoia and delusions and may lead to persistent visual disturbances known as hallucinogen persisting perception disorder (HPPD).

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Lysergic acid diethylamide in the context of Psychedelic drug

Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic hallucinogens or serotonergic hallucinogens, the term psychedelic is sometimes used more broadly to include various other types of hallucinogens as well, such as those which are atypical or adjacent to psychedelia like salvia and MDMA, respectively.

Classic psychedelics generally cause specific psychological, visual, and auditory changes, and oftentimes a substantially altered state of consciousness. They have had the largest influence on science and culture, and include mescaline, LSD, psilocybin, and DMT. There are a large number of both naturally occurring and synthetic serotonergic psychedelics.

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Lysergic acid diethylamide in the context of Brainwashing

Brainwashing is the systematic effort to get someone to adopt a particular deception, loyalty, instruction, or doctrine without their will or awareness. Brainwashing is also a colloquial term that refers in general to psychological techniques that manipulate action or thought against a person's will, desire, or knowledge. It attempts to damage individual or group attitudes, frames of reference, beliefs, values or loyalties by demonstrating that current thinking patterns and attitudes are wrong and need change. Brainwashing is said to reduce its subject's ability to think critically or independently, to allow the introduction of new, unwanted thoughts and ideas into their minds.

The term "brainwashing" was first used in English by Edward Hunter in 1950 to describe how the Chinese government appeared to make people cooperate with them during the Korean War. Research into the concept also looked at Nazi Germany and present-day North Korea, at some criminal cases in the United States, and at the actions of human traffickers. Scientific and legal debate followed, as well as media attention, about the possibility of brainwashing being a factor when lysergic acid diethylamide (LSD) was used, or in the induction of people into groups which are considered to be cults.

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Lysergic acid diethylamide in the context of Psychoactive drug

A psychoactive drug, psychopharmaceutical, mind-altering drug, consciousness-altering drug, psychoactive substance, or psychotropic substance is a chemical substance that alters psychological functioning by modulating central nervous system (CNS) activity. Psychoactive and psychotropic drugs both affect the brain, with psychotropics sometimes referring to psychiatric drugs or high-abuse substances, while “drug” can have negative connotations. Novel psychoactive substances are designer drugs made to mimic illegal ones and bypass laws.

Psychoactive drug use dates back to prehistory for medicinal and consciousness-altering purposes, with evidence of widespread cultural use. Many animals intentionally consume psychoactive substances, and some traditional legends suggest animals first introduced humans to their use. Psychoactive substances are used across cultures for purposes ranging from medicinal and therapeutic treatment of mental disorders and pain, to performance enhancement. Their effects are influenced by the drug itself, the environment, and individual factors. Psychoactive drugs are categorized by their pharmacological effects into types such as anxiolytics (reduce anxiety), empathogen–entactogens (enhance empathy), stimulants (increase CNS activity), depressants (decrease CNS activity), and hallucinogens (alter perception and emotions). Psychoactive drugs are administered through various routes—including oral ingestion, injection, rectal use, and inhalation—with the method and efficiency differing by drug.

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Lysergic acid diethylamide in the context of Psychedelic experience

A psychedelic experience (known colloquially as a trip) is a temporary altered state of consciousness induced by the consumption of a psychedelic substance (most commonly LSD, mescaline, psilocybin mushrooms, or DMT). For example, an acid trip is a psychedelic experience brought on by the use of LSD, while a mushroom trip is a psychedelic experience brought on by the use of psilocybin. Psychedelic experiences feature alterations in normal perception such as visual distortions and a subjective loss of self-identity, sometimes interpreted as mystical experiences. Psychedelic experiences lack predictability, as they can range from being highly pleasurable (known as a good trip) to frightening (known as a bad trip). The outcome of a psychedelic experience is heavily influenced by the person's mood, personality, expectations, and environment (also known as set and setting).

Researchers have interpreted psychedelic experiences in light of a range of scientific theories, including model psychosis theory, filtration theory, psychoanalytic theory, entropic brain theory, integrated information theory, and predictive processing. Psychedelic experiences are also induced and interpreted in religious and spiritual contexts.

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Lysergic acid diethylamide in the context of Dimethyltryptamine

Dimethyltryptamine (DMT), also known as N,N-dimethyltryptamine (N,N-DMT), is a serotonergic hallucinogen and investigational drug of the tryptamine family that occurs naturally in many plants and animals. DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen.

DMT has a rapid onset, intense effects, and a relatively short duration of action. For those reasons, DMT was known as the "businessman's trip" during the 1960s in the United States, as a user could access the full depth of a psychedelic experience in considerably less time than with other substances such as LSD or psilocybin mushrooms. DMT can be inhaled or injected and its effects depend on the dose, as well as the mode of administration. When inhaled or injected, the effects last about five to fifteen minutes. Effects can last three hours or more when orally ingested along with a monoamine oxidase inhibitor (MAOI), such as the ayahuasca brew of many native Amazonian tribes. DMT induces intense, often indescribable subjective experiences involving vivid visual hallucinations, altered sensory perception, ego dissolution, and encounters with seemingly autonomous entities. DMT is generally considered non-addictive with low dependence and no tolerance buildup, but it may cause acute psychological distress or cardiovascular effects, especially in predisposed individuals.

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Lysergic acid diethylamide in the context of Hippie

A hippie, also spelled hippy, especially in British English, is someone associated with the counterculture of the mid-1960s to early 1970s, originally a youth movement that began in the United States and spread to different countries around the world. The word hippie came from hipster and was used to describe beatniks who moved into New York City's Greenwich Village, San Francisco's Haight-Ashbury district, Los Angeles' Laurel Canyon, and Chicago's Old Town community. The term hippie was used in print by San Francisco writer Michael Fallon, helping popularize use of the term in the media, although the tag was seen elsewhere earlier.

The origins of the terms hip and hep are uncertain. By the 1940s, both had become part of African American jive slang and meant "sophisticated; currently fashionable; fully up-to-date". The Beats adopted the term hip, and early hippies adopted the language and countercultural values of the Beat Generation. Hippies created their own communities, listened to psychedelic music, embraced the sexual revolution, and many used drugs such as marijuana and LSD to explore altered states of consciousness.

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