Lorenzo de' Medici in the context of "The Battle of San Romano"

The Italian Wars were a series of conflicts fought between 1494 and 1559, mostly in the Italian Peninsula, later expanding into Flanders, the Rhineland and Mediterranean Sea. The primary belligerents were the Valois kings of France, on one side, and their Habsburg opponents in the Holy Roman Empire and Spain on the other. Numerous Italian states participated at different stages, some on both sides, with limited involvement from England, and the Ottoman Empire.

The 1454 Italic League achieved a balance of power in Italy, but disintegrated after the death of its chief architect, Lorenzo de' Medici, in 1492. Combined with the ambition of Ludovico Sforza, its collapse allowed Charles VIII of France to invade Naples in 1494, which drew in Spain and the Holy Roman Empire. Although Charles was forced to withdraw in 1495, ongoing political divisions among the Italian states made them a battleground in the struggle for European domination between France and the Habsburgs.

Pope Leo X (Italian: Leone X; born Giovanni di Lorenzo de' Medici, 11 December 1475 – 1 December 1521) was head of the Catholic Church and ruler of the Papal States from 9 March 1513 to his death in December 1521.

Born into the prominent political and banking Medici family of Florence, Giovanni was the second son of Lorenzo de' Medici, ruler of the Florentine Republic, and was elevated to the cardinalate in 1489. Following the death of Pope Julius II, Giovanni was elected pope after securing the backing of the younger members of the College of Cardinals. Early on in his rule he oversaw the closing sessions of the Fifth Council of the Lateran, but struggled to implement the reforms agreed. In 1517 he led a costly war that succeeded in securing his nephew Lorenzo di Piero de' Medici as Duke of Urbino, but reduced papal finances.

The House of Medici (English: /ˈmɛdɪtʃi/ MED-itch-ee, UK also /məˈdiːtʃi/ mə-DEE-chee; Italian: [ˈmɛːditʃi]) was an Italian banking family and political dynasty that first consolidated power in the Republic of Florence under Cosimo de' Medici and his grandson Lorenzo "the Magnificent" during the first half of the 15th century. The family originated in the Mugello region of Tuscany, and prospered gradually in trade until it was able to fund the Medici Bank. This bank was the largest in Europe in the 15th century and facilitated the Medicis' rise to political power in Florence, although they officially remained citizens rather than monarchs until the 16th century.

In 1532, the family acquired the hereditary title Duke of Florence. In 1569, the duchy was elevated to the Grand Duchy of Tuscany after territorial expansion. The Medici ruled the Grand Duchy from its inception under the builder Cosimo I until 1737, with the death of Gian Gastone de' Medici. The Medici produced four popes of the Catholic Church—Pope Leo X (1513–1521), Pope Clement VII (1523–1534), Pope Pius IV (1559–1565) and Pope Leo XI (1605)—and two queens of France—Catherine de' Medici (1547–1559) and Marie de' Medici (1600–1610). The Medici's grand duchy witnessed degrees of economic growth under the early grand dukes, but was bankrupt by the time of Cosimo III de' Medici (r. 1670–1723).

Italian literature is written in the Italian language, particularly within Italy. It may also refer to literature written by Italians or in other languages spoken in Italy, often languages that are closely related to modern Italian, including regional varieties and vernacular dialects.

Italian literature began in the 12th century, when in different regions of the peninsula the Italian vernacular started to be used in a literary manner. The Ritmo laurenziano is the first extant document of Italian literature. In 1230, the Sicilian School became notable for being the first style in standard Italian. Renaissance humanism developed during the 14th and the beginning of the 15th centuries. Lorenzo de' Medici is regarded as the standard bearer of the influence of Florence on the Renaissance in the Italian states. The development of the drama in the 15th century was very great. In the 16th century, the fundamental characteristic of the era following the end of the Renaissance was that it perfected the Italian character of its language. Niccolò Machiavelli and Francesco Guicciardini were the chief originators of the science of history. Pietro Bembo was an influential figure in the development of the Italian language. In 1690, the Academy of Arcadia was instituted with the goal of "restoring" literature by imitating the simplicity of the ancient shepherds with sonnets, madrigals, canzonette, and blank verses.

Ginevra de' Benci (1457–1521) was a member of the Benci family in Florence and is the subject of an early portrait by Leonardo da Vinci.

Ginevra was born into a family of wealthy Florentine merchants in 1457. The Benci had business dealings with the Medici and were noted humanists themselves, patronizing artists and writers and creating an important library of classical texts. In 1474 she married Luigi de Bernardo Niccolini. Bernardo Bembo, Lorenzo de' Medici, Alessandro Braccesi, and Christoforo Landino dedicated poems to her.

The Pazzi conspiracy (Italian: Congiura dei Pazzi) was a failed plot by members of the Pazzi family and others to displace the Medici family as rulers of Renaissance Florence.

On 26 April 1478 (Easter Sunday) there was an attempt to assassinate Lorenzo de' Medici and his brother Giuliano. Lorenzo was wounded but survived; Giuliano was killed.