The War of Urbino (January–September 1517) was a secondary episode of the Italian Wars.
The conflict ensued after the end of the War of the League of Cambrai (1508–16), when Francesco Maria I della Rovere decided to take advantage of the situation to recover the Duchy of Urbino, from which he had been ousted in the previous year by troops of the Papal States.
Pope Leo X (Italian: Leone X; born Giovanni di Lorenzo de' Medici, 11 December 1475 – 1 December 1521) was head of the Catholic Church and ruler of the Papal States from 9 March 1513 to his death in December 1521.
Born into the prominent political and banking Medici family of Florence, Giovanni was the second son of Lorenzo de' Medici, ruler of the Florentine Republic, and was elevated to the cardinalate in 1489. Following the death of Pope Julius II, Giovanni was elected pope after securing the backing of the younger members of the College of Cardinals. Early on in his rule he oversaw the closing sessions of the Fifth Council of the Lateran, but struggled to implement the reforms agreed. In 1517 he led a costly war that succeeded in securing his nephew Lorenzo di Piero de' Medici as Duke of Urbino, but reduced papal finances.
Ludovico de' Medici, also known as Giovanni delle Bande Nere (6 April 1498 – 30 November 1526) was an Italian condottiero. He is known for leading the Black Bands and serving valiantly in military combat under his third cousins, Pope Leo X and Pope Clement VII, in the War of Urbino and the War of the League of Cognac, respectively.