Leprosy in the context of Pathogenicity

Bacteria are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit the air, soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria play a vital role in many stages of the nutrient cycle by recycling nutrients and the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in mutualistic, commensal and parasitic relationships with plants and animals. Most bacteria have not been characterised and there are many species that cannot be grown in the laboratory. The study of bacteria is known as bacteriology, a branch of microbiology.

Like all animals, humans carry vast numbers (approximately 10 to 10) of bacteria. Most are in the gut, though there are many on the skin. Most of the bacteria in and on the body are harmless or rendered so by the protective effects of the immune system, and many are beneficial, particularly the ones in the gut. However, several species of bacteria are pathogenic and cause infectious diseases, including cholera, syphilis, anthrax, leprosy, tuberculosis, tetanus and bubonic plague. The most common fatal bacterial diseases are respiratory infections. Antibiotics are used to treat bacterial infections and are also used in farming, making antibiotic resistance a growing problem. Bacteria are important in sewage treatment and the breakdown of oil spills, the production of cheese and yogurt through fermentation, the recovery of gold, palladium, copper and other metals in the mining sector (biomining, bioleaching), as well as in biotechnology, and the manufacture of antibiotics and other chemicals.

Molokaʻi or Molokai is the fifth most populated of the eight major islands that make up the Hawaiian Islands archipelago in the middle of the Pacific Ocean. It is 38 by 10 miles (61 by 16 km) at its greatest length and width with a usable land area of 260 sq mi (673.40 km), making it the fifth largest in size of the main Hawaiian Islands and the 27th-largest island in the United States. It lies southeast of Oʻahu across the 25-mile-wide (40 km) Kaʻiwi Channel and north of Lānaʻi, separated from it by the Kalohi Channel.

The island's agrarian economy has been driven primarily by cattle ranching, pineapple production, sugarcane production and small-scale farming. Tourism comprises a small fraction of the island's economy, and much of the infrastructure related to tourism was closed and barricaded in the early 2000s when the primary landowner, Molokai Ranch, ceased operations due to substantial revenue losses. In Kalawao County, on the Kalaupapa Peninsula on the north coast, settlements were established in 1866 for quarantined treatment of persons with leprosy; these operated until 1969. The Kalaupapa National Historical Park now preserves this entire county and area. Several other islands are visible from the shores of Molokaʻi, including Oʻahu from the west shores; Lānaʻi from the south shores, and Maui from the south and east shores.

Peripheral neuropathy, often shortened to neuropathy, refers to damage or disease affecting the nerves. Damage to nerves may impair sensation, movement, gland function, and/or organ function depending on which nerve fibers are affected. Neuropathies affecting motor, sensory, or autonomic nerve fibers result in different symptoms. More than one type of fiber may be affected simultaneously. Peripheral neuropathy may be acute (with sudden onset, rapid progress) or chronic (symptoms begin subtly and progress slowly), and may be reversible or permanent.

Common causes include systemic diseases (such as diabetes or leprosy), hyperglycemia-induced glycation, vitamin deficiency, medication (e.g., chemotherapy, or commonly prescribed antibiotics including metronidazole and the fluoroquinolone class of antibiotics (such as ciprofloxacin, levofloxacin, moxifloxacin)), traumatic injury, ischemia, radiation therapy, excessive alcohol consumption, immune system disease, celiac disease, non-celiac gluten sensitivity, or viral infection. It can also be genetic (present from birth) or idiopathic (no known cause). In conventional medical usage, the word neuropathy (neuro-, "nervous system" and -pathy, "disease of") without modifier usually means peripheral neuropathy.

The Cagots (pronounced [ka.ɡo]) were a persecuted minority who lived in the west of France and northern Spain: the Navarrese Pyrenees, Basque provinces, Béarn, Aragón, Gascony and Brittany. Evidence of the group exists as far back as 1000 CE. The name they were known by varied across the regions where they lived.

The origins of the Cagots remain uncertain, with various hypotheses proposed throughout history. Some theories suggest they were descendants of biblical or legendary figures cursed by God, or the descendants of medieval lepers, while others propose they were related to the Cathars or even a fallen guild of carpenters. Some suggest descent from a variety of other marginalized racial or religious groups. Despite the varied and often mythical explanations for their origins, the only consistent aspect of the Cagots was their societal exclusion and the lack of any distinct physical or cultural traits differentiating them from the general population.

A blister is a small pocket of body fluid (lymph, serum, plasma, blood, or pus) within the upper layers of the skin, usually caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection. Most blisters are filled with a clear fluid, either serum or plasma. However, blisters can be filled with blood (known as "blood blisters") or with pus (for instance, if they become infected).

Smaller blisters are called blebs. The word "blister" entered English in the 14th century. It came from the Middle Dutch bluyster and was a modification of the Old French blostre, which meant a leprous nodule—a rise in the skin due to leprosy.

Mycobacterium lepromatosis is an aerobic, acid-fast bacillus (AFB), and the second known causative agent of Hansen's disease (leprosy). It was discovered in 2008. Analysis of the 16S rRNA gene confirms that the species is distinct from Mycobacterium leprae.

Marianne Cope, OSF (also known as Marianne of Molokaʻi; January 23, 1838 – August 9, 1918) was a German-born American Religious Sister who was a member of the Sisters of St. Francis of Syracuse, New York, and founding director of its St. Joseph's Hospital in the city, among the first of 50 general hospitals in the country. In 1883 she led a group of six other Sisters to the Kingdom of Hawaii to care for persons suffering leprosy on the island of Molokaʻi and aid in developing the medical infrastructure in Hawaiʻi. Despite direct contact with the patients over many years, Cope did not contract the disease.

In 2005, Marianne was beatified by decision of Pope Benedict XVI. She was canonized (declared a saint) by the same pope on October 21, 2012, along with Kateri Tekakwitha, a 17th-century Native American. Cope was the 11th Catholic active in what is now the United States to be canonized by the Catholic Church.

Naaman the Aramean (Hebrew: נַעֲמָן, romanized: Naʿmān, lit. 'pleasantness') was a commander of the armies of Hadadezer, the king of Aram-Damascus, in the time of Jehoram, King of Northern Israel (Samaria).

According to 2 Kings 5 in the Bible, Naaman was a commander of the army of Aram. He was a good commander and was held in favor because of the victory that God brought him. However, Naaman suffered from tzaraath, a skin disease often translated as "leprosy".

Dovrefjell is a mountain range in Central Norway that forms a natural barrier between Eastern Norway and Trøndelag. The mountain range is located in Innlandet, Møre og Romsdal, and Trøndelag counties in Norway. As a result of its central location, its valleys and passes have been heavily trafficked during and probably preceding historical times. Several mountain inns were established in the Middle Ages to house pilgrims traveling through Dovrefjell to Trondheim, and there are even ruins of an old leper colony in the northern area of it.

The main south-north highway (European route E6) and the Dovrebanen railway line both run through a mountain pass in the Dovrefjell range. The highway is a year-round highway but on rare occasions it is closed for short periods during heavy winter weather conditions. The mountain range runs through Oppdal Municipality in Trøndelag county, Folldal Municipality, Dovre Municipality, and Lesja Municipality in Innlandet county, and Sunndal Municipality in Møre og Romsdal county. The municipalities of Oppdal, Folldal, and Dovre, together, make up what is sometimes known as the Dovre Region.

The chiesa di Sant'Agostino (Church of St Augustine) is the second largest church in San Gimignano, Italy, after the Collegiata. It is owned by the Order of Saint Augustine.

Sant'Agostino is an imposing 13th century building. The interior is a large hall dominated by the seventeen-panel fresco cycle on The Life of St Augustine around the high altar, painted by Benozzo Gozzoli between 1463 and 1467. By Benozzo is also a votive fresco of Saint Sebastian commissioned by the Augustinians after the 1464 plague. Unlike traditional depictions the Saint as a martyr, he is shown in a tunicle and large cloak, shielding the population praying at his feet. A painted inscription on the floor dates the work to July 28, 1464. The altarpiece is the Coronation of the Virgin by Piero del Pollaiuolo (1483). There are a number of other frescoes in the church. The Cappella di San Bartolo houses the remains of the eponymous saint (1228–1300), a lay Franciscan who died of leprosy. The magnificent altar in the chapel is by Benedetto da Maiano.

Mycobacteriaceae is a family of bacteria in the phylum Actinomycetota. Its name is derived from the Mycobacterium genus, which includes pathogens known to cause serious diseases in mammals, including tuberculosis (M. tuberculosis) and leprosy (M. leprae) in humans. The Greek prefix myco- means 'fungus', alluding to the mold-like appearance of these organisms on agar plates.

The Ziehl–Neelsen stain, also known as the acid-fast stain, is a bacteriological staining technique used in cytopathology and microbiology to identify acid-fast bacteria under microscopy, particularly members of the Mycobacterium genus. This staining method was initially introduced by Paul Ehrlich (1854–1915) and subsequently modified by the German bacteriologists Franz Ziehl (1859–1926) and Friedrich Neelsen (1854–1898) during the late 19th century.

The acid-fast staining method, in conjunction with auramine phenol staining, serves as the standard diagnostic tool and is widely accessible for rapidly diagnosing tuberculosis (caused by Mycobacterium tuberculosis) and other diseases caused by atypical mycobacteria, such as leprosy (caused by Mycobacterium leprae) and Mycobacterium avium-intracellulare infection (caused by Mycobacterium avium complex) in samples like sputum, gastric washing fluid, and bronchoalveolar lavage fluid. These acid-fast bacteria possess a waxy lipid-rich outer layer that contains high concentrations of mycolic acid, rendering them resistant to conventional staining techniques like the Gram stain.

Mary Teresa Bojaxhiu (born Anjezë Gonxhe Bojaxhiu, Albanian: [aˈɲɛzə ˈɡɔndʒɛ bɔjaˈdʒi.u]; 26 August 1910 – 5 September 1997), better known as Mother Teresa or Saint Mother Teresa, was an Albanian-Indian Catholic nun, founder of the Missionaries of Charity and is a Catholic saint. Born in Skopje, then part of the Ottoman Empire, she was raised in a devoutly Catholic family. At the age of 18, she moved to Ireland to join the Sisters of Loreto and later to India, where she lived most of her life and carried out her missionary work. On 4 September 2016, she was canonised by the Catholic Church as Saint Teresa of Calcutta. The anniversary of her death, 5 September, is now observed as her feast day.

In 1950, Mother Teresa established the Missionaries of Charity, a religious congregation that was initially dedicated to serving "the poorest of the poor" in the slums of Calcutta. Over the decades, the congregation grew to operate in over 133 countries, as of 2012, with more than 4,500 nuns managing homes for those dying from HIV/AIDS, leprosy, and tuberculosis, as well as running soup kitchens, dispensaries, mobile clinics, orphanages, and schools. Members of the order take vows of chastity, poverty, and obedience and also profess a fourth vow: to give "wholehearted free service to the poorest of the poor."

A leper colony, also known by many other names, is an isolated community for the quarantining and treatment of lepers, people suffering from leprosy.

M. leprae, the bacterium responsible for leprosy, is believed to have spread from East Africa through the Near East, Europe, and Asia by the 5th century before reaching the rest of the world more recently. Historically, leprosy was believed to be extremely contagious and divinely ordained, leading to enormous stigma against its sufferers. Other severe skin diseases were frequently conflated with leprosy and all such sufferers were kept away from the general public, although some religious orders provided medical care and treatment. Recent research has shown M. leprae has maintained a similarly virulent genome over at least the last thousand years, leaving it unclear which precise factors led to leprosy's near elimination in Europe by 1700. A growing number of cases following the first wave of European colonization, however, led to increased attention towards leprosy during the New Imperialism of the late 19th century. Following G. A. Hansen's discovery of the role of M. leprae in the disease, the First International Leprosy Conference held in Berlin in 1897 renewed interest and investment in the isolation of lepers throughout the European colonial empires.