Leprosy in the context of "Chronic condition"

Bacteria are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit the air, soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria play a vital role in many stages of the nutrient cycle by recycling nutrients and the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in mutualistic, commensal and parasitic relationships with plants and animals. Most bacteria have not been characterised and there are many species that cannot be grown in the laboratory. The study of bacteria is known as bacteriology, a branch of microbiology.

Like all animals, humans carry vast numbers (approximately 10 to 10) of bacteria. Most are in the gut, though there are many on the skin. Most of the bacteria in and on the body are harmless or rendered so by the protective effects of the immune system, and many are beneficial, particularly the ones in the gut. However, several species of bacteria are pathogenic and cause infectious diseases, including cholera, syphilis, anthrax, leprosy, tuberculosis, tetanus and bubonic plague. The most common fatal bacterial diseases are respiratory infections. Antibiotics are used to treat bacterial infections and are also used in farming, making antibiotic resistance a growing problem. Bacteria are important in sewage treatment and the breakdown of oil spills, the production of cheese and yogurt through fermentation, the recovery of gold, palladium, copper and other metals in the mining sector (biomining, bioleaching), as well as in biotechnology, and the manufacture of antibiotics and other chemicals.

Molokaʻi or Molokai is the fifth most populated of the eight major islands that make up the Hawaiian Islands archipelago in the middle of the Pacific Ocean. It is 38 by 10 miles (61 by 16 km) at its greatest length and width with a usable land area of 260 sq mi (673.40 km), making it the fifth largest in size of the main Hawaiian Islands and the 27th-largest island in the United States. It lies southeast of Oʻahu across the 25-mile-wide (40 km) Kaʻiwi Channel and north of Lānaʻi, separated from it by the Kalohi Channel.

The island's agrarian economy has been driven primarily by cattle ranching, pineapple production, sugarcane production and small-scale farming. Tourism comprises a small fraction of the island's economy, and much of the infrastructure related to tourism was closed and barricaded in the early 2000s when the primary landowner, Molokai Ranch, ceased operations due to substantial revenue losses. In Kalawao County, on the Kalaupapa Peninsula on the north coast, settlements were established in 1866 for quarantined treatment of persons with leprosy; these operated until 1969. The Kalaupapa National Historical Park now preserves this entire county and area. Several other islands are visible from the shores of Molokaʻi, including Oʻahu from the west shores; Lānaʻi from the south shores, and Maui from the south and east shores.

Peripheral neuropathy, often shortened to neuropathy, refers to damage or disease affecting the nerves. Damage to nerves may impair sensation, movement, gland function, and/or organ function depending on which nerve fibers are affected. Neuropathies affecting motor, sensory, or autonomic nerve fibers result in different symptoms. More than one type of fiber may be affected simultaneously. Peripheral neuropathy may be acute (with sudden onset, rapid progress) or chronic (symptoms begin subtly and progress slowly), and may be reversible or permanent.

Common causes include systemic diseases (such as diabetes or leprosy), hyperglycemia-induced glycation, vitamin deficiency, medication (e.g., chemotherapy, or commonly prescribed antibiotics including metronidazole and the fluoroquinolone class of antibiotics (such as ciprofloxacin, levofloxacin, moxifloxacin)), traumatic injury, ischemia, radiation therapy, excessive alcohol consumption, immune system disease, celiac disease, non-celiac gluten sensitivity, or viral infection. It can also be genetic (present from birth) or idiopathic (no known cause). In conventional medical usage, the word neuropathy (neuro-, "nervous system" and -pathy, "disease of") without modifier usually means peripheral neuropathy.

The Cagots (pronounced [ka.ɡo]) were a persecuted minority who lived in the west of France and northern Spain: the Navarrese Pyrenees, Basque provinces, Béarn, Aragón, Gascony and Brittany. Evidence of the group exists as far back as 1000 CE. The name they were known by varied across the regions where they lived.

The origins of the Cagots remain uncertain, with various hypotheses proposed throughout history. Some theories suggest they were descendants of biblical or legendary figures cursed by God, or the descendants of medieval lepers, while others propose they were related to the Cathars or even a fallen guild of carpenters. Some suggest descent from a variety of other marginalized racial or religious groups. Despite the varied and often mythical explanations for their origins, the only consistent aspect of the Cagots was their societal exclusion and the lack of any distinct physical or cultural traits differentiating them from the general population.

A blister is a small pocket of body fluid (lymph, serum, plasma, blood, or pus) within the upper layers of the skin, usually caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection. Most blisters are filled with a clear fluid, either serum or plasma. However, blisters can be filled with blood (known as "blood blisters") or with pus (for instance, if they become infected).

Smaller blisters are called blebs. The word "blister" entered English in the 14th century. It came from the Middle Dutch bluyster and was a modification of the Old French blostre, which meant a leprous nodule—a rise in the skin due to leprosy.

Mycobacterium lepromatosis is an aerobic, acid-fast bacillus (AFB), and the second known causative agent of Hansen's disease (leprosy). It was discovered in 2008. Analysis of the 16S rRNA gene confirms that the species is distinct from Mycobacterium leprae.