Khadija bint Khuwaylid in the context of "Fatima"

From 613 to 619 CE, the Islamic prophet Muhammad gathered in his hometown of Mecca a small following of those who embraced his message of Islam and thus became Muslims. The first person who professed Islam was his wife, Khadija bint Khuwaylid. The identity of the second male Muslim, after Muhammad himself, is disputed largely along sectarian lines, as Shia and some Sunni sources identify him as the first Shia imam Ali ibn Abi Talib, a child at the time, who grew up in the household of his cousin, Muhammad. Other sources report that the first male convert was Abu Bakr, who later succeeded Muhammad as the first Sunni caliph, or Muhammad's foster son, Zayd ibn Haritha. While it is difficult to establish the chronological order of early conversions, the identities of early Muslims are known with some certainty.

Zayd ibn Ḥāritha al-Kalbī (Arabic: زيد بن حارثة الكلبي) (c. 581–629 CE), was an early Muslim, Sahabi and the former adopted son of the Islamic prophet, Muhammad. He is commonly regarded as the fourth person to have accepted Islam, after Muhammad's wife Khadija, Muhammad's cousin Ali, and Muhammad's close companion Abu Bakr. Zayd was a slave that Hakim ibn Hizam, Khadija's nephew, bought for her at a market in Ukaz. Zayd then became her and Muhammad’s adopted son and took his lineage. His lineage was later restored just before he had his second wife Zaynab bint Jahsh divorced and married to Muhammad. He later went on to marry into Muhammad's family.

Zayd was a commander in the early Muslim army and led several early military expeditions during the lifetime of Muhammad. Zayd led his final expedition in September 629 CE, when he set out to raid the Byzantine city of Bosra. However the Muslim army was intercepted by Byzantine forces and Zayd was subsequently killed at the Battle of Mu'tah.

Aisha bint Abi Bakr (c. 614 CE – July 678) was a muhadditha, political figure, and the third and youngest wife of Islamic prophet Muhammad. Following the death of and succession to Muhammad, she was politically active during the caliphates of Abu Bakr, Umar and Uthman, and stands out as a prominent female figure during the period.

Aisha played a significant role in early Islamic history, both during Muhammad's life and after his death. She is regarded in Sunni tradition as intelligent, inquisitive, and scholarly, and is often described as Muhammad's most beloved wife after Khadija bint Khuwaylid. She contributed to the transmission of Muhammad's teachings and remained active in the Muslim community for 44 years after his death. Aisha is credited with narrating over 2,000 hadiths, covering not only aspects of Muhammad's personal life but also legal, ritual, and theological subjects such as inheritance, pilgrimage, prayer, and eschatology. Her intellectual abilities and knowledge of poetry, medicine, and Islamic jurisprudence were praised by early scholars, including al-Zuhri and her student Urwa ibn al-Zubayr.

Al-Qāsim ibn Muḥammad (Arabic: القاسم بن محمد) was the eldest of the sons of Muhammad and Khadija bint Khuwaylid. He died in 601 CE (before the declaration of his father's prophethood in 609), after his third birthday, and is buried in Jannat al-Mu'alla cemetery, Mecca. Ibn Majah mentioned that he died before completing his milk age.

ʿAbd Allāh ibn Muḥammad (Arabic: عَبْد ٱللَّٰه ٱبْن مُحَمَّد) also known as al-Ṭāhir (lit. 'the pure') and al-Ṭayyib (lit. 'the good') was one of the sons of Muhammad and Khadija. He died in childhood.