Interstate 90 in the context of "O'Hare, Chicago"

Interstate 40 (I-40) is a major east–west transcontinental Interstate Highway in the southeastern and southwestern portions of the United States. At a length of 2,556.61 miles (4,114.46 km), it is the third-longest Interstate Highway in the country, after I-90 and I-80. From west to east, it passes through California, Arizona, New Mexico, Texas, Oklahoma, Arkansas, Tennessee, and North Carolina. Its western terminus is at I-15 in Barstow, California, while its eastern terminus is at a concurrency with U.S. Route 117 (US 117) and North Carolina Highway 132 (NC 132) in Wilmington, North Carolina. Major cities served by the Interstate include Flagstaff, Arizona; Albuquerque, New Mexico; Amarillo, Texas; Oklahoma City, Oklahoma; Fort Smith and Little Rock in Arkansas; Memphis, Nashville, and Knoxville in Tennessee; and Asheville, Winston-Salem, Greensboro, Durham, Raleigh, and Wilmington in North Carolina.

I-40 begins in the Mojave Desert in California, and then proceeds through the Colorado Plateau in Arizona and the southern tip of the Rocky Mountains in New Mexico. It then traverses the Great Plains through the Texas Panhandle and Oklahoma, and passes south of the Ozarks in Arkansas. The freeway crosses the Appalachian Mountains in Tennessee and North Carolina, before terminating in the Atlantic Coastal Plain near the Atlantic Ocean.

Interstate 25 (I-25), also known as the Pan-American Freeway, is a major Interstate Highway in the western United States. It is primarily a north–south highway, serving as the main route through New Mexico, Colorado, and Wyoming. I-25 stretches from I-10 at Las Cruces, New Mexico (approximately 25 miles [40 km] north of El Paso, Texas) to I-90 in Buffalo, Wyoming (approximately 60 miles [97 km] south of the Montana–Wyoming border). It passes through or near Albuquerque, New Mexico; Pueblo, Colorado Springs, and Denver in Colorado; and Cheyenne and Casper in Wyoming. The I-25 corridor is mainly rural, especially in Wyoming, excluding the Albuquerque metropolitan area and the Front Range urban corridor from Pueblo to Cheyenne.

The part of I-25 in Colorado passes just east of the Front Range of the Rocky Mountains. That stretch was involved in a large-scale renovation named the Transportation Expansion (T-REX) Project in Denver and the Colorado Springs Metropolitan Interstate Expansion (COSMIX). These projects, and others in New Mexico, were necessary because these stretches of I-25 were originally inadequately designed and constructed (the pavement was deteriorating rapidly) and also because urban areas, like Albuquerque, Colorado Springs, and Denver, had tripled and quadrupled in population much earlier than anyone had anticipated back in the 1950s and 1960s. Major highway work for the T-REX project ended on August 22, 2006. The COSMIX project was completed in December 2007. Several other smaller improvement projects for I-25 are still ongoing within New Mexico and Colorado.

Interstate 94 (I-94) is an east–west Interstate Highway connecting the Great Lakes and northern Great Plains regions of the United States. Its western terminus is just east of Billings, Montana, at a junction with I-90; its eastern terminus is in Port Huron, Michigan, where it meets with I-69 and crosses the Blue Water Bridge into Sarnia, Ontario, Canada, where the route becomes Ontario Highway 402. It thus lies along the primary overland route from Seattle (via I-90) to Toronto (via Ontario Highway 401) and is the only east–west Interstate Highway to have a direct connection to Canada. It is the longest Interstate whose route number is not divisible by 5.

I-94 intersects with I-90 several times: at its western terminus; Tomah to Madison in Wisconsin; in Chicago, Illinois; and in Lake Station, Indiana. Major cities that I-94 connects to are Billings, Bismarck, Fargo, Minneapolis–Saint Paul, Madison, Milwaukee, Chicago, and Detroit.

Interstate 10 (I-10) is the southernmost transcontinental highway in the Interstate Highway System of the United States. It is the fourth-longest Interstate in the country at 2,460.34 miles (3,959.53 km), following I-90, I-80, and I-40. It was part of the originally planned Interstate Highway network that was laid out in 1956, and its last section was completed in 1990.

I-10 stretches from the Pacific Ocean at State Route 1 (SR 1, Pacific Coast Highway) in Santa Monica, California, to I-95 in Jacksonville, Florida. Other major cities connected by I-10 include (from west to east) Los Angeles, Phoenix, Tucson, Las Cruces, El Paso, San Antonio, Houston, Baton Rouge, New Orleans, Gulfport, Mobile, Pensacola, and Tallahassee. Over one-third of its total length is within the state of Texas, where the freeway spans the state at its widest breadth.

U.S. Route 14 or U.S. Highway 14 (US 14), an east–west route, is one of the original United States Numbered Highways of 1926. It is about 1,445 miles (2,326 km) long. It is roughly parallel to Interstate 90 (I-90).

The highway's eastern terminus is in Chicago, Illinois. Its western terminus is the east entrance of Yellowstone National Park in Wyoming, with the western terminus of US 16 and the western terminus of the eastern segment of US 20.

The I-90 Mississippi River Bridge, or the Dresbach Bridge, consists of a pair of parallel bridges that traverse the Mississippi River, connecting the La Crosse, Wisconsin area to Dresbach in rural Winona County, Minnesota. The current bridge was fully opened to traffic in October 2016, replacing a previous 1967 plate girder bridge. It is part of the Interstate 90 route. There is another automobile crossing a few miles south of this bridge; the Mississippi River Bridge, a combination of two bridges, and the La Crosse West Channel Bridge, connecting La Crescent, Minnesota and La Crosse, Wisconsin.

The bridge consists of a pair of parallel, concrete box girder structures over the main river channel and precast concrete girder structures over the back channels. The bridges were completed with a cost of $185.5 million, and have the following specifications:

Interstate 80 (I-80) is an east–west transcontinental freeway that crosses the United States from San Francisco, California, to Teaneck, New Jersey, in the New York metropolitan area. The highway was designated in 1956 as one of the original routes of the Interstate Highway System; its final segment was opened in 1986. At a length of 2,900.76 miles (4,668.32 km), it is the second-longest Interstate Highway in the United States, after I-90. It runs through many major cities, including Oakland, Sacramento, Reno, Salt Lake City, Cheyenne, Omaha, Des Moines, and Toledo, and passes within 10 miles (16 km) of Chicago, Cleveland, and New York City.

I-80 is the Interstate Highway that most closely approximates the route of the historic Lincoln Highway, the first trans-continental auto trail. The highway roughly traces other historically significant travel routes in the Western United States: the Oregon Trail across Wyoming and Nebraska, the California Trail across most of Nevada and California, the first transcontinental airmail route, and the route of the first transcontinental railroad, except for the vicinity of the Great Salt Lake.

The Ted Williams Tunnel is a highway tunnel in Boston, Massachusetts. The third in the city to travel under Boston Harbor, with the Sumner Tunnel and the Callahan Tunnel, it carries the final segment of Interstate 90 (the Massachusetts Turnpike) from South Boston towards its eastern terminus at Route 1A in East Boston, slightly beyond Logan International Airport. The tunnel is named after the Boston Red Sox baseball legend Ted Williams.

The underwater section of the tunnel is 90 feet below the surface of Boston Harbor, the deepest such connection in North America.

The Big Dig ceiling collapse occurred on July 10, 2006, when a concrete ceiling panel and debris weighing 26 short tons (52,000 lb; 24,000 kg) and measuring 20 by 40 feet (6.1 by 12.2 m) fell in Boston's Fort Point Channel Tunnel (which connects to the Ted Williams Tunnel). The panel fell on a car traveling on the two-lane ramp connecting northbound I-93 to eastbound I-90 in South Boston, killing a passenger and injuring the driver. Investigation and repair of the collapse caused a section of the Big Dig project to be closed for almost a year, causing chronic traffic backups.