Interstate 40 in the context of "Little Rock"

Interstate 95 (I-95) is the main north–south Interstate Highway on the East Coast of the United States, running from U.S. Route 1 (US 1) in Miami, Florida, north to the Houlton–Woodstock Border Crossing between Maine and the Canadian province of New Brunswick. The highway largely parallels the Atlantic coast and US 1, except for the portion between Savannah, Georgia, and Washington, D.C., and the portion between Portland and Houlton in Maine, both of which follow a more direct inland route.

I-95 serves as the principal road link between the major cities of the Eastern Seaboard. Major metropolitan areas along its route include Miami, Jacksonville, and Savannah in the Southeast; Richmond, Washington, Baltimore, Wilmington–Philadelphia, Newark, and New York City in the Mid-Atlantic; and New Haven, Providence, Boston, and Portland in New England. The Charleston, Wilmington, and Norfolk–Virginia Beach metropolitan areas, the three major coastal metros bypassed by the highway's inland portion, are connected to I-95 by I-26, I-40, and I-64, respectively.

Interstate 30 (I-30) is a major Interstate Highway in the southern states of Texas and Arkansas in the United States. I-30 travels 366.76 miles (590.24 km) from I-20 west of Fort Worth, Texas, northeast via Dallas, and Texarkana, Texas, to I-40 in North Little Rock, Arkansas. The highway parallels U.S. Route 67 (US 67) except for the portion west of Downtown Dallas (which was once part of I-20). Between the termini, I-30 has interchanges with I-35W, I-35E, and I-45. I-30 is known as the Tom Landry Freeway between I-35W and I-35E, within the core of the Dallas–Fort Worth metroplex.

Petrified Forest National Park is a national park of the United States in Navajo and Apache counties in northeastern Arizona. Named for its large deposits of petrified wood, the park covers about 346 square miles (900 square kilometers), encompassing semi-desert shrub steppe as well as highly eroded and colorful badlands. The park's headquarters is about 26 miles (42 km) east of Holbrook along Interstate 40 (I-40), which parallels the BNSF Railway's Southern Transcon, the Puerco River, and historic U.S. Route 66, all crossing the park roughly east–west. The site, the northern part of which extends into the Painted Desert, was declared a national monument in 1906 and a national park in 1962. The park received 644,922 recreational visitors in 2018.

Averaging about 5,400 feet (1,600 m) in elevation, the park has a dry windy climate with temperatures that vary from summer highs of about 100 °F (38 °C) to winter lows well below freezing. More than 400 species of plants, dominated by grasses such as bunchgrass, blue grama, and sacaton, are found in the park. Fauna include larger animals such as pronghorns, coyotes, and bobcats; many smaller animals, such as deer mice, snakes, lizards, and seven kinds of amphibians; and more than 200 species of birds, some of which are permanent residents and many of which are migratory. About one third of the park is designated wilderness—50,260 acres (79 sq mi; 203 km).

The term Cross Timbers, also known as Ecoregion 29, Central Oklahoma/Texas Plains, is used to describe a strip of land in the United States that runs from southeastern Kansas across Central Oklahoma to Central Texas. Made up of a mix of prairie, savanna, and woodland, it forms part of the boundary between the more heavily forested eastern country and the almost treeless Great Plains, and also marks the western habitat limit of many mammals and insects.

No major metropolitan areas lie wholly within the Cross Timbers, although roughly the western half of the Dallas-Fort Worth Metroplex does, including the cities of Fort Worth, Denton, Arlington, and Weatherford. The western suburbs of the Tulsa metropolitan area and the northeastern suburbs of the Oklahoma City metropolitan area also lie within this area. The main highways that cross the region are I-35 and I-35W going north to south (although they tend to skirt the Cross Timbers' eastern fringe south of Fort Worth), and both I-40 and I-44 going east to west. Numerous U.S. Highways also cross the area. I-35 means a portion of Austin and Travis County is also included in the Cross Timbers.

Interstate 10 (I-10) is the southernmost transcontinental highway in the Interstate Highway System of the United States. It is the fourth-longest Interstate in the country at 2,460.34 miles (3,959.53 km), following I-90, I-80, and I-40. It was part of the originally planned Interstate Highway network that was laid out in 1956, and its last section was completed in 1990.

I-10 stretches from the Pacific Ocean at State Route 1 (SR 1, Pacific Coast Highway) in Santa Monica, California, to I-95 in Jacksonville, Florida. Other major cities connected by I-10 include (from west to east) Los Angeles, Phoenix, Tucson, Las Cruces, El Paso, San Antonio, Houston, Baton Rouge, New Orleans, Gulfport, Mobile, Pensacola, and Tallahassee. Over one-third of its total length is within the state of Texas, where the freeway spans the state at its widest breadth.

Mojave National Preserve is a US National Preserve located in the Mojave Desert of San Bernardino County, California, between Interstate 15 and Interstate 40. Established in 1994, it is the third largest unit of the National Park system within the contiguous United States, and the largest national preserve.

The preserve spans 1,542,776 acres (6,243 km). It surrounds Providence Mountains State Recreation Area and Mitchell Caverns Natural Preserve, which are both managed by the California Department of Parks and Recreation.

The West Mesa (New Mexican Spanish: Atrisco) is an elevated landmass lying west of the Rio Grande, and the westside of Albuquerque, stretching from the South Valley northward to Bernalillo and Rio Rancho in the U.S. state of New Mexico.

The eastern edge of the West Mesa is defined by an escarpment that borders the Rio Grande floodplain. The West Mesa also serves as the easternmost extent of the Colorado Plateau in this region. The western edge of the mesa is the Rio Puerco near the Laguna Pueblo about 20 miles (32 km) west of Albuquerque. A large portion of the West Mesa is part of Petroglyph National Monument. It is bisected by Interstate 40 and Historic Route 66. Atrisco Vista (previously named Paseo del Volcan) (NM 347) runs north-south on the West Mesa, connecting I-40/US-66 to Double Eagle II Airport.

U.S. Route 50 or U.S. Highway 50 (US 50) is a major east–west route of the U.S. Highway system, stretching 3,019 miles (4,859 km) from Interstate 80 (I-80) in West Sacramento, California, to Maryland Route 528 (MD 528) in Ocean City, Maryland, on the Atlantic Ocean. Until 1972, when it was replaced by Interstate Highways west of the Sacramento area, it extended (by way of Stockton, the Altamont Pass, and the Bay Bridge) to San Francisco, near the Pacific Ocean. The Interstates were constructed later and are mostly separate from this route. It generally serves a corridor south of I-70 and I-80 and north of I-64 and I-40.

The route runs through mostly rural desert and mountains in the western United States, with the section through Nevada known as "The Loneliest Road in America". In the Midwest, US 50 heads through mostly rural areas of farms as well as a few large cities including Kansas City, Missouri; St. Louis, Missouri; and Cincinnati, Ohio.