Hospitaller Malta, known in Maltese history as the Knights' Period (Maltese: Żmien il-Kavallieri, lit. 'Time of the Knights'), was a de facto state which existed between 1530 and 1798 when the Mediterranean islands of Malta and Gozo were ruled by the Order of St. John of Jerusalem. It was formally a vassal state of the Kingdom of Sicily, and it came into being when Emperor Charles V granted the islands as well as the city of Tripoli in modern Libya to the Order, following the latter's loss of Rhodes in 1522. Hospitaller Tripoli was lost to the Ottoman Empire in 1551, but an Ottoman attempt to take Malta in 1565 failed.
Following the 1565 siege, the Order decided to settle permanently in Malta and began to construct a new capital city, Valletta. For the next two centuries, Malta went through a Golden Age, characterized by a flourishing of the arts, architecture, and an overall improvement in Maltese society. In the mid-17th century, the Order was the de jure proprietor over some islands in the Caribbean, making it the smallest state to colonize the Americas.