Great Siege of Malta in the context of "History of Malta"

A series of military conflicts between the Ottoman Empire and various European states took place from the Late Middle Ages up through the early 20th century. The earliest conflicts began during the Byzantine–Ottoman wars, waged in Anatolia in the late 13th century before entering Europe in the mid-14th century with the Bulgarian–Ottoman wars. The mid-15th century saw the Serbian–Ottoman wars and the Albanian-Ottoman wars. Much of this period was characterized by the Ottoman expansion into the Balkans. The Ottoman Empire made further inroads into Central Europe in the 15th and 16th centuries, culminating in the peak of Ottoman territorial claims in Europe.

The Ottoman–Venetian wars spanned four centuries, starting in 1423 and lasting until 1718. This period witnessed the fall of Negroponte in 1470, the siege of Malta in 1565, the fall of Famagusta (Cyprus) in 1571, the defeat of the Ottoman fleet at the Battle of Lepanto in 1571 (at that time the largest naval battle in history), the fall of Candia (Crete) in 1669, the Venetian reconquest of Morea (Peloponnese) in the 1680s and its loss again in 1715. The island of Venetian-ruled Corfu remained the only Greek island not conquered by the Ottomans.

Valletta (/vəˈlɛtʌ/ ; Maltese: il-Belt Valletta, lit. 'the city [of] Valletta', pronounced [ɪlˈbɛlt vɐˈlːɛtːɐ]), also known as Città Umilissima (transl. the Humblest City), is the capital city of Malta and one of its 68 council areas. Located between the Grand Harbour to the east and Marsamxett Harbour to the west, its population as of 2021 was 5,157. As Malta’s capital city, it is a commercial centre for shopping, bars, dining, and café life. It is also the southernmost capital of Europe, and, at just 0.61 square kilometres (0.24 sq mi), it is the European Union's smallest capital city.

Valletta's 16th-century buildings were constructed by the Knights Hospitaller. The city was named after the Frenchman Jean Parisot de Valette, who succeeded in defending the island against an Ottoman invasion during the Great Siege of Malta. The city is Baroque in character, with elements of Mannerist, Neo-Classical and Modern architecture, though the Second World War left major scars on the city, particularly the destruction of the Royal Opera House. The city was officially recognised as a World Heritage Site by UNESCO in 1980. The city has 320 monuments, all within an area of 0.55 square kilometres (0.21 sq mi), making it one of the most concentrated historic areas in the world. Sometimes called an "open-air museum", Valletta was chosen as the European Capital of Culture for 2018. Valletta was also listed as the sunniest city in Europe in 2016.

Hospitaller Malta, known in Maltese history as the Knights' Period (Maltese: Żmien il-Kavallieri, lit. 'Time of the Knights'), was a de facto state which existed between 1530 and 1798 when the Mediterranean islands of Malta and Gozo were ruled by the Order of St. John of Jerusalem. It was formally a vassal state of the Kingdom of Sicily, and it came into being when Emperor Charles V granted the islands as well as the city of Tripoli in modern Libya to the Order, following the latter's loss of Rhodes in 1522. Hospitaller Tripoli was lost to the Ottoman Empire in 1551, but an Ottoman attempt to take Malta in 1565 failed.

Following the 1565 siege, the Order decided to settle permanently in Malta and began to construct a new capital city, Valletta. For the next two centuries, Malta went through a Golden Age, characterized by a flourishing of the arts, architecture, and an overall improvement in Maltese society. In the mid-17th century, the Order was the de jure proprietor over some islands in the Caribbean, making it the smallest state to colonize the Americas.

Fra' Jean "Parisot" de (la) Valette (French pronunciation: [ʒɑ̃ paʁizo d(ə) (la) valɛt]; c. 4 February 1495 – 21 August 1568) was a French nobleman and 49th Grand Master of the Order of Malta, from 21 August 1557 to his death in 1568. As a Knight Hospitaller, joining the order in the Langue de Provence, he fought with distinction against the Turks at Rhodes. As Grand Master, Valette became the Order's hero and most illustrious leader, commanding the resistance against the Ottomans at the Great Siege of Malta in 1565, sometimes regarded as one of the greatest sieges of all time.

The foundation stone of Valletta was laid by Grandmaster La Valette in 1566. He did not live to see Valletta completed, as he died in 1568 and was succeeded by Grandmaster Pierre de Monte.