Hibernation in the context of Obligate

A season is a division of the year based on changes in weather, ecology, and the number of daylight hours in a given region. On Earth, seasons are the result of the axial parallelism of Earth's tilted orbit around the Sun. In temperate and polar regions, the seasons are marked by changes in the intensity of sunlight that reaches the Earth's surface, variations of which may cause animals to undergo hibernation or to migrate, and plants to be dormant. Various cultures define the number and nature of seasons based on regional variations, and as such there are a number of both modern and historical definitions of the seasons.

The Northern Hemisphere experiences most direct sunlight during May, June, and July (thus the traditional celebration of Midsummer in June), as the hemisphere faces the Sun. For the Southern Hemisphere it is instead in November, December, and January. It is Earth's axial tilt that causes the Sun to be higher in the sky during the summer months, which increases the solar flux. Because of seasonal lag, June, July, and August are the warmest months in the Northern Hemisphere while December, January, and February are the warmest months in the Southern Hemisphere.

The Marsican brown bear (Ursus arctos arctos, formerly Ursus arctos marsicanus), also known as the Apennine brown bear, is a critically endangered population of the Eurasian brown bear, with a range restricted to the Parco Nazionale d'Abruzzo, Lazio e Molise, and the surrounding region in Italy. The Marsican brown bear differs slightly from other brown bears in its appearance and hibernation techniques. The bear's popular name is derived from Marsica, a historic area of the modern-day region of Abruzzo where the bear has long had a significant presence.

With their existence dwindling, the Italian government has recently begun to stress their conservation. The park has become a sanctuary dedicated to animals such as the Marsican brown bear, with hopes of rekindling the large, yet isolative bears' once-thriving existence. Debate exists as to whether it should be considered a subspecies or a taxon of its own.

Suspended animation is the slowing or stopping of biological function so that physiological capabilities are preserved. States of suspended animation are common in micro-organisms and some plant tissue, such as seeds. Many animals, including large ones, may undergo hibernation, and most plants have periods of dormancy. This article focuses primarily on the potential of large animals, especially humans, to undergo suspended animation.

In animals, suspended animation may be either hypometabolic or ametabolic in nature. It may be induced by either endogenous, natural or artificial biological, chemical or physical means. In its natural form, it may be spontaneously reversible as in the case of species demonstrating hypometabolic states of hibernation. When applied with therapeutic intent, as in deep hypothermic circulatory arrest (DHCA), usually technologically mediated revival is required.

The Himalayan brown bear (Ursus arctos isabellinus), also known as the Himalayan red bear or isabelline bear, is a subspecies of the brown bear occurring in the western Himalayas. It is the largest mammal in the region, males reaching up to 2.2 m (7 ft 3 in) long, while females are a little smaller. It is omnivorous and hibernates in dens during the winter.

Bears are carnivoran mammals of the family Ursidae (/ˈɜːrsɪdiː, -daɪ/). They are classified as caniforms, or doglike carnivorans. Although only eight species of bears are extant, they are widespread, appearing in a wide variety of habitats throughout most of the Northern Hemisphere and partially in the Southern Hemisphere. Bears are found on the continents of North America, South America, and Eurasia. Common characteristics of modern bears include large bodies with stocky legs, long snouts, small rounded ears, shaggy hair, plantigrade paws with five nonretractile claws, and short tails.

While the polar bear is mostly carnivorous, and the giant panda is mostly herbivorous, the remaining six species are omnivorous with varying diets. With the exception of courting individuals and mothers with their young, bears are typically solitary animals. They may be diurnal or nocturnal and have an excellent sense of smell. Despite their heavy build and awkward gait, they are adept runners, climbers, and swimmers. Bears use shelters, such as caves and logs, as their dens; most species occupy their dens during the winter for a long period of hibernation, up to 100 days.

Aestivation (Latin: aestas (summer); also estivation in American English) is a state of animal dormancy, similar to hibernation, although taking place in the summer rather than the winter. Aestivation is characterized by inactivity and a lowered metabolic rate, that is entered in response to high temperatures and arid conditions. It takes place during times of heat and dryness, which are often the summer months.

Invertebrate and vertebrate animals enter an aestivating state to avoid damage from high temperatures and the risk of desiccation. Both terrestrial and aquatic animals undergo aestivation. Fossil records suggest that aestivation may have evolved several hundred million years ago.

Tropical diseases are infectious diseases that are prevalent in or unique to tropical and subtropical regions. The diseases are less prevalent in temperate climates, due in part to the occurrence of a cold season, which controls the insect population by forcing hibernation. However, many were present in Northern Europe and Northern America in the 17th and 18th centuries before modern understanding of disease causation. The initial impetus for tropical medicine was to protect the health of colonial settlers, notably in India under the British Raj. Insects such as mosquitoes and flies are by far the most common disease carrier, or vector. These insects may carry a parasite, bacterium or virus that is infectious to humans and animals. Most often disease is transmitted by an insect bite, which causes transmission of the infectious agent through subcutaneous blood exchange. Vaccines are not available for most of the diseases listed here, and many do not have cures.

Human exploration of tropical rainforests, deforestation, rising immigration and increased international air travel and other tourism to tropical regions has led to an increased incidence of such diseases to non-tropical countries. Of particular concern is the habitat loss of reservoir host species.

Overwintering is the process by which some organisms pass through or wait out the winter season, or pass through that period of the year when "winter" conditions (cold or sub-zero temperatures, ice, snow, limited food supplies) make normal activity or even survival difficult or near impossible. In some cases "winter" is characterized not necessarily by cold but by dry conditions; passing through such periods could likewise be called overwintering.

Hibernation and migration are the two major ways in which overwintering is accomplished. Animals may also go into a state of reduced physiological activity known as torpor.

Bears are carnivoran mammals of the family Ursidae (/ˈɜːrsɪdiː, -daɪ/). They are classified as caniforms, or doglike carnivorans. Although only eight species of bears are extant, they are widespread, appearing in a wide variety of habitats throughout most of the Northern Hemisphere and partially in the Southern Hemisphere. Bears are found on the continents of North America, South America, and Eurasia. Common characteristics of modern bears include large bodies with stocky legs, long snouts, small rounded ears, shaggy hair, plantigrade paws with five nonretractile claws, and short tails.

While the polar bear is mostly carnivorous, and the giant panda is mostly herbivorous, the remaining six species are omnivorous with varying diets. With the exception of courting individuals and mothers with their young, bears are typically solitary animals. They may be diurnal or nocturnal, and they have an excellent sense of smell. Despite their heavy build and awkward gait, they are adept runners, climbers, and swimmers. Bears use shelters, such as caves and logs, as their dens; most species occupy their dens during the winter for a long period of hibernation, up to 100 days.

The black-tailed prairie dog (Cynomys ludovicianus) is a rodent of the family Sciuridae (the squirrels) found in the Great Plains of North America from about the United States–Canada border to the United States–Mexico border. Unlike some other prairie dogs, these animals do not truly hibernate. The black-tailed prairie dog can be seen above ground in midwinter. A black-tailed prairie dog town in Texas was reported to cover 25,000 mi (64,000 km) and included 400,000,000 individuals. Prior to habitat destruction, the species may have been the most abundant prairie dog in central North America. It was one of two prairie dogs described by the Lewis and Clark Expedition in the journals and diaries of their expedition.

Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration, and this complex links the glycolysis metabolic pathway to the citric acid cycle. Pyruvate decarboxylation is also known as the "pyruvate dehydrogenase reaction" because it also involves the oxidation of pyruvate. The levels of pyruvate dehydrogenase enzymes play a major role in regulating the rate of carbohydrate metabolism and are strongly stimulated by the evolutionarily ancient hormone insulin. The PDC is opposed by the activity of pyruvate dehydrogenase kinase, and this mechanism plays a pivotal role in regulating rates of carbohydrate and lipid metabolism in many physiological states across taxa, including feeding, starvation, diabetes mellitus, hyperthyroidism, and hibernation.

The multienzyme complex is structurally and functionally related to the oxoglutarate dehydrogenase complex (OGDC), the 2-oxoadipate dehydrogenase complex (OADHC) and the branched-chain oxo-acid dehydrogenase complex (BCKDC), all of which are members of the 2-oxoacid dehydrogenase complex family. A role for insulin in the regulation of glucose homeostasis, pyruvate dehydrogenase levels, and the generation of AMP-activated protein kinase (AMPK) in the electron transport chain has been evolutionarily conserved across species. A shift in substrate utilization can be induced by conditions such as eating or fasting, and the oxidation of either glucose or fatty acids tends to suppress the use of the other substrate (a phenomenon known as the Randle cycle). The intake of macronutrients stimulates the secretion and release of insulin and other chemical messengers such as glucagon-like peptide 1 (GLP-1), which act to regulate glucose levels, insulin sensitivity, satiety, and fat balance in the body. In the postprandial period, insulin is produced by the pancreas and serves to activate carbohydrate metabolism and stimulate glucose disposal in order to meet metabolic demands and prevent glucotoxicity. When insulin is unable to efficiently stimulate glucose utilization, the body's tissues become resistant to its hypoglycemic effects, promoting the development of a state of insulin resistance over time. This can happen because of chronic exposure to hyperinsulinemia due to poor diet, sedentary lifestyle, obesity, and other potentially modifiable risk factors. The phenomenon is similar to leptin resistance and can potentially lead to many deleterious health effects stemming from chronically elevated insulin levels, such as excessive fat storage and de novo synthesis, hepatic and peripheral insulin resistance, nonalcoholic fatty liver disease] (NAFLD), hypertension and dyslipidemia, and decreased resting energy expenditure (REE) caused by impaired diet-induced thermogenesis.