Heterozygote advantage in the context of "Fixation (population genetics)"

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⭐ Core Definition: Heterozygote advantage

A heterozygote advantage describes the case in which the heterozygous genotype has a higher relative fitness than either the homozygous dominant or homozygous recessive genotype. Loci exhibiting heterozygote advantage are a small minority of loci. The specific case of heterozygote advantage due to a single locus is known as overdominance. Overdominance is a rare condition in genetics where the phenotype of the heterozygote lies outside of the phenotypical range of both homozygote parents, and heterozygous individuals have a higher fitness than homozygous individuals.

Polymorphism can be maintained by selection favoring the heterozygote, and this mechanism is used to explain the occurrence of some kinds of genetic variability. A common example is the case where the heterozygote conveys both advantages and disadvantages, while both homozygotes convey a disadvantage. A well-established case of heterozygote advantage is that of the gene involved in sickle cell anaemia.

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👉 Heterozygote advantage in the context of Fixation (population genetics)

In population genetics, fixation is the change in a gene pool from a situation where there exists at least two variants of a particular gene (allele) in a given population to a situation where only one of the alleles remains. That is, the allele becomes fixed. In the absence of mutation or heterozygote advantage, any allele must eventually either be lost completely from the population, or fixed, i.e. permanently established at 100% frequency in the population. Whether a gene will ultimately be lost or fixed is dependent on selection coefficients and chance fluctuations in allelic proportions. Fixation can refer to a gene in general or particular nucleotide position in the DNA chain (locus).

In the process of substitution, a previously non-existent allele arises by mutation and undergoes fixation by spreading through the population by random genetic drift or positive selection. Once the frequency of the allele is at 100%, i.e. being the only gene variant present in any member, it is said to be "fixed" in the population.

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Heterozygote advantage in the context of Biology and sexual orientation

The relationship between biology and sexual orientation is a subject of ongoing research. While scientists do not know the exact cause of sexual orientation, they theorize that it is caused by a complex interplay of genetic, hormonal, and environmental influences. However, evidence is weak for hypotheses that the postnatal social environment impacts sexual orientation, especially for males.

Biological theories for explaining the causes of sexual orientation are favored by scientists. These factors, which may be related to the development of a sexual orientation, include genes, the early uterine environment (such as prenatal hormones), and brain structure. While the evolutionary explanation for heterosexuality in organisms that reproduce sexually is straightforwardly understood to be a psychological adaptation resulting from greater reproductive success, evolutionary explanations for homosexuality rely upon other mechanisms of evolution such as kin selection and inclusive fitness, or antagonistic pleiotropy that favors heterozygotes causing homosexuality among homozygotes as a by-product.

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Heterozygote advantage in the context of Host–parasite coevolution

Host–parasite coevolution is a special case of coevolution, where a host and a parasite continually adapt to each other. This can create an evolutionary arms race between them. A more benign possibility is of an evolutionary trade-off between transmission and virulence in the parasite, as if it kills its host too quickly, the parasite will not be able to reproduce either. Another theory, the Red Queen hypothesis, proposes that since both host and parasite have to keep on evolving to keep up with each other, and since sexual reproduction continually creates new combinations of genes, parasitism favours sexual reproduction in the host.

The genetic changes involved are changes in frequencies of alleles, variant forms of individual genes, within populations. These are determined by three main types of selection dynamics: negative frequency-dependent selection when a rare allele has a selective advantage; heterozygote advantage; and directional selection near an advantageous allele. A possible result is a geographic mosaic in a parasitised population, as both host and parasite adapt to environmental conditions that vary in space and time.

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LINKED FROM (PARENTS)
← Fixation (population genetics) ← Biology and sexual orientation ← Host–parasite coevolution
LINKS TO (CHILDREN)
Heterozygous → Genotype → Fitness (biology) → Homozygous → Dominance (genetics) → Recessive gene → Locus (genetics) → Overdominance → Phenotype → Polymorphism (biology) → Natural selection → Genetic variation → Sickle-cell disease →