Francisco Varela in the context of "Humberto Maturana"

The term autopoiesis (from Greek αὐτo- (auto) 'self' and ποίησις (poiesis) 'creation, production'), one of several current theories of life, refers to a system capable of producing and maintaining itself by creating its own parts.The term was introduced in the 1972 publication Autopoiesis and Cognition: The Realization of the Living by Chilean biologists Humberto Maturana and Francisco Varela to define the self-maintaining chemistry of living cells.

The concept has since been applied to the fields of cognition, neurobiology, systems theory, architecture and sociology. Niklas Luhmann briefly introduced the concept of autopoiesis to organizational theory.

Enactivism is a position in cognitive science that argues that cognition arises through a dynamic interaction between an acting organism and its environment. It claims that the environment of an organism is brought about, or enacted, by the active exercise of that organism's sensorimotor processes. "The key point, then, is that the species brings forth and specifies its own domain of problems ...this domain does not exist "out there" in an environment that acts as a landing pad for organisms that somehow drop or parachute into the world. Instead, living beings and their environments stand in relation to each other through mutual specification or codetermination" (p. 198). "Organisms do not passively receive information from their environments, which they then translate into internal representations. Natural cognitive systems...participate in the generation of meaning ...engaging in transformational and not merely informational interactions: they enact a world." These authors suggest that the increasing emphasis upon enactive terminology presages a new era in thinking about cognitive science. How the actions involved in enactivism relate to age-old questions about free will remains a topic of active debate.

The term 'enactivism' is close in meaning to 'enaction', defined as "the manner in which a subject of perception creatively matches its actions to the requirements of its situation". The introduction of the term enaction in this context is attributed to Francisco Varela, Evan Thompson, and Eleanor Rosch in The Embodied Mind (1991), who proposed the name to "emphasize the growing conviction that cognition is not the representation of a pre-given world by a pre-given mind but is rather the enactment of a world and a mind on the basis of a history of the variety of actions that a being in the world performs". This was further developed by Thompson and others, to place emphasis upon the idea that experience of the world is a result of mutual interaction between the sensorimotor capacities of the organism and its environment. However, some writers maintain that there remains a need for some degree of the mediating function of representation in this new approach to the science of the mind.

Radical constructivism is an approach to epistemology that situates knowledge in terms of knowers' experience. It looks to break with the conception of knowledge as a correspondence between a knower's understanding of their experience and the world beyond that experience. Adopting a skeptical position towards correspondence as in principle impossible to verify because one cannot access the world beyond one's experience in order to test the relation, radical constructivists look to redefine epistemology in terms of the viability of knowledge within knowers' experience. This break from the traditional framing of epistemology differentiates it from "trivial" forms of constructivism that emphasise the role of the knower in constructing knowledge while maintaining the traditional perspective of knowledge in terms of correspondence. Radical constructivism has been described as a "post-epistemological" position.

Radical constructivism was initially formulated by Ernst von Glasersfeld, who drew on the work of Jean Piaget, Giambattista Vico, and George Berkeley amongst others. Radical constructivism is closely related to second-order cybernetics, and especially the work of Heinz von Foerster, Humberto Maturana, and Francisco Varela. During the 1980s, Siegfried J. Schmidt played a leading role in establishing radical constructivism as a paradigm within the German speaking academic world.