The fall of Tenochtitlan, the capital of the Aztec Empire, was an important event in the Spanish conquest of the empire. It occurred in 1521 following extensive negotiations between local factions and Spanish conquistador Hernán Cortés. He was aided by La Malinche, his interpreter and companion, and by thousands of indigenous allies, especially Tlaxcaltec warriors.
Although numerous battles were fought between the Aztec Empire and the Spanish-led coalition, which was composed mainly of Tlaxcaltec men, it was the siege of Tenochtitlan that directly led to the fall of the Aztec civilization and the ensuing sacking and violence against the survivors. The indigenous population at the time was devastated due to a smallpox epidemic, which killed much of its leadership. Because smallpox had been endemic in Spain for centuries, the Spanish had developed an acquired immunity and were affected relatively little in the epidemic.
