Erectile dysfunction in the context of "Prostaglandin E1"

Sexology is the scientific study of human sexuality, including human sexual interests, behaviors, and functions. The term sexology does not generally refer to the non-scientific study of sexuality, such as social criticism.

Sexologists apply tools from several academic fields, such as anthropology, biology, medicine, psychology, epidemiology, sociology, and criminology. Topics of study include sexual development (puberty), sexual orientation, gender identity, sexual relationships, sexual activities, paraphilias, and atypical sexual interests. It also includes the study of sexuality across the lifespan, including child sexuality, puberty, adolescent sexuality, and sexuality among the elderly. Sexology also spans sexuality among those with mental or physical disabilities. The sexological study of sexual dysfunctions and disorders, including erectile dysfunction and anorgasmia, are also mainstays.

Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. Symptoms may include frequent urination, trouble starting to urinate, weak stream, inability to urinate, or loss of bladder control. Complications can include urinary tract infections, bladder stones, and chronic kidney problems.

The cause is unclear. Risk factors include a family history, obesity, type 2 diabetes, not enough exercise, and erectile dysfunction. Medications like pseudoephedrine, anticholinergics, and calcium channel blockers may worsen symptoms. The underlying mechanism involves the prostate pressing on the urethra thereby making it difficult to pass urine out of the bladder. Diagnosis is typically based on symptoms and examination after ruling out other possible causes.

Peyronie's disease (PD) is a benign, acquired penile connective tissue disease characterized by the occurrence of fibrotic plaques within the tunica albuginea — the dense elastic covering of the corpora cavernosa. The plaques cause abnormal curvature, pain, penile deformities (e.g., narrowing or indentation), and usually erectile dysfunction, particularly during erection. The condition typically leads to significant sexual and psychological effects, including difficulty with penetration and lowered self-esteem or evasiveness. Peyronie's disease is most often seen in middle-aged and older men with a median age of onset between 55 and 60 years, however it is also common in younger individuals and adolescents.

While the etiology of Peyronie's disease is still uncertain, the leading hypothesis is that it arises from dysregulated wound healing in response to chronic microtrauma of the erect penis. This triggers a cascade of profibrotic molecular pathways — most notably overexpression of transforming growth factor-beta 1 (TGF-β1) — that end in fibroblast proliferation, myofibroblast differentiation, and overproduction of type I collagen. Genetic predisposition is supported by family clustering and linkage with systemic fibrosing disorders such as Dupuytren's contracture. Risk factors include age, penile injury, diabetes mellitus, and cigarette smoking.

Papaverine (Latin papaver, "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasms and vasospasms (especially those involving the intestines, heart, or brain), occasionally in the treatment of erectile dysfunction and acute mesenteric ischemia. While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic morphine and its derivatives (such as codeine).

In addition to opium, papaverine is purported to be present in high concentrations in star gooseberry.

Polysomnography (PSG) is a multi-parameter type of sleep study and a diagnostic tool in sleep medicine. The test result is called a polysomnogram, also abbreviated PSG. The name is derived from Greek and Latin roots: the Greek πολύς (polus for "many, much", indicating many channels), the Latin somnus ("sleep"), and the Greek γράφειν (graphein, "to write").

Type I polysomnography is a sleep study performed overnight with the patient continuously monitored by a credentialed technologist. It records the physiological changes that occur during sleep, usually at night, though some labs can accommodate shift workers and people with circadian rhythm sleep disorders who sleep at other times. The PSG monitors many body functions, including brain activity (EEG), eye movements (EOG), muscle activity or skeletal muscle activation (EMG), and heart rhythm (ECG). After the identification of the sleep disorder sleep apnea in the 1970s, breathing functions, respiratory airflow, and respiratory effort indicators were added along with peripheral pulse oximetry. Polysomnography no longer includes NPT monitoring for erectile dysfunction, as it is reported that all male patients will experience erections during phasic REM sleep, regardless of dream content.

A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues. These drugs dilate the corpora cavernosa of the penis, facilitating erection with sexual stimulation, and are used in the treatment of erectile dysfunction (ED). Sildenafil was the first effective oral treatment available for ED. Because PDE5 is also present in the smooth muscle of the walls of the arterioles within the lungs, two PDE5 inhibitors, sildenafil and tadalafil, are FDA-approved for the treatment of pulmonary hypertension. As of 2019, the wider cardiovascular benefits of PDE5 inhibitors are being appreciated.

Sexual frustration is a sense of dissatisfaction stemming from a discrepancy between a person's desired and achieved sexual activity. It may result from physical, legal, mental, emotional, social, financial, religious or spiritual barriers. It can derive from displeasure during sex due to issues such as anorgasmia, anaphrodisia, premature ejaculation, delayed ejaculation or erectile dysfunction. A sense of incompatibility or discrepancy in libido between partners may be involved. It may also relate to broader existential frustration.

Sexual frustration can potentially have a number of consequences, and like other frustrations, can increase the risks of aggression, violence, or crime. Some mass shooters, incels, and other criminals have cited sexual frustration as one reason for their anger.

Reasons for opposition to pornography include religious objections, moral values, feminist concerns, as well as harmful effects, such as pornography addiction and erectile dysfunction. Pornography addiction is not a condition recognized by the DSM-5, the ICD-11, or the DSM-5-TR. Anti-pornography movements have allied disparate social activists in opposition to pornography, from social conservatives to harm reduction advocates. The definition of "porn" varies between countries and movements, and many make distinctions between pornography, which they oppose, and erotica, which they consider acceptable. Sometimes opposition will deem certain forms of pornography more or less harmful, while others draw no such distinctions.

A 2018 Gallup survey reported that 43% of U.S. adults believe that pornography is "morally acceptable", a 7% increase from 2017. From 1975 to 2012, the gender gap in pornography opposition has widened, with more women increasingly opposed to pornography, and men's opposition rate declining faster.