East Tennessee in the context of "Tennessee State Route 32"

U.S. Route 25E (US 25E) is the eastern branch of US 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin. The highway, however, continues as US 25E for roughly two miles (3.2 km) until it joins Interstate 75 (I-75) in the Laurel County community of North Corbin at exit 29. The highway serves the Appalachia regions of Kentucky's Cumberland Plateau and the Ridge-and-Valley section of East Tennessee, including the urbanized areas of Corbin and Middlesboro in Kentucky and Morristown in Tennessee.

US 25E follows the original pathway of early U.S. pioneer Daniel Boone's Wilderness Road, which contributed to the increased settlement of Appalachia given its access through the rugged Cumberland Gap. By 1815, the route became the first state-funded road in Tennessee and, in 1923, unsigned State Route 32 (SR 32) in the Tennessee State Route System in its statewide entirety. It would be recognized as part of the Dixie Highway, one of the earliest federal auto trails, in 1915. The route was officially established as US 25E with the creation of the U.S. Numbered Highway System in 1926.

Tennessee (/ˌtɛnɪˈsiː/ , locally /ˈtɛnɪsi/), officially the State of Tennessee, is a landlocked state in the Southeastern region of the United States. It borders Kentucky to the north, Virginia to the northeast, North Carolina to the east, Georgia, Alabama, and Mississippi to the south, Arkansas to the southwest, and Missouri to the northwest. Tennessee is the 36th-largest by area and the 15th-most populous of the 50 states. According to the United States Census Bureau, the state's estimated population as of 2024 is 7.22 million.

Tennessee is geographically, culturally, and legally divided into three Grand Divisions of East, Middle, and West Tennessee. Nashville is the state's capital and largest city, and anchors its largest metropolitan area. Tennessee has diverse terrain and landforms, and from east to west, contains a mix of cultural features characteristic of Appalachia, the Upland South, and the Deep South. The Blue Ridge Mountains along the eastern border reach some of the highest elevations in eastern North America, and the Cumberland Plateau contains many scenic valleys and waterfalls. The central part of the state is marked by cavernous bedrock and irregular rolling hills, and level, fertile plains define West Tennessee. The state is twice bisected by the Tennessee River, and the Mississippi River forms its western border. The Great Smoky Mountains National Park, the nation's most visited national park, is in eastern Tennessee.

In the United States, Southern Unionists were white Southerners living in the Confederate States of America and the Southern Border States opposed to secession. Many fought for the Union during the Civil War. These people are also referred to as Southern Loyalists, Union Loyalists, or Lincoln's Loyalists. Pro-Confederates in the South derided them as "Tories" (in reference to the pro-Crown Loyalists of the American Revolution). During Reconstruction, these terms were replaced by "scalawag" (or "scallywag"), which covered all Southern whites who supported the Republican Party.

Tennessee (especially East Tennessee), Kentucky, Maryland, Missouri, Delaware, North Carolina, and Virginia (which included West Virginia at that time) were home to the largest populations of Unionists. Other (primarily Appalachian) areas with significant Unionist influence included North Alabama, North Georgia, Western North Carolina, the Texas Hill Country, northern Loudoun County in Virginia, North Mississippi, North Texas, the Arkansas Ozarks, and the Boston Mountains in Arkansas. These areas provided thousands of volunteers for Union military service. Western North Carolinians, for example, formed their own loyalist infantry, cavalry, and artillery regiments, while West Virginians formed a new Union state admitted in 1863.

Knoxville is a city in Knox County, Tennessee, United States, and its county seat. Located on the Tennessee River within the Appalachian Mountains, it is the largest city in the Grand Division of East Tennessee. Knoxville had a population of 190,740 at the 2020 census, making it the third-most populous city in Tennessee. The Knoxville metropolitan area has an estimated 958,000 residents.

Settled in 1786, Knoxville was the first capital of Tennessee. The city struggled with geographic isolation throughout the early 19th century before the arrival of the railroad in 1855 led to an economic boom. The city was bitterly divided over the issue of secession during the American Civil War and was occupied alternately by the Confederate and Union armies, which culminated in the Battle of Fort Sanders in 1863. Following the war, Knoxville grew rapidly and became a major wholesaling and manufacturing center until the 1920s when the city's economy began to stagnate. During the Great Depression, Knoxville's manufacturing sector collapsed, the downtown area declined, and city leaders became entrenched in highly partisan political fights. Hosting the 1982 World's Fair helped reinvigorate the city, and revitalization initiatives by city leaders and private developers have spurred growth in the city, especially downtown.

David Crockett (August 17, 1786 – March 6, 1836) was an American politician, militia officer and frontiersman. Often referred to in popular culture as the "King of the Wild Frontier", he represented Tennessee in the United States House of Representatives and fought in the Texas Revolution.

Crockett grew up in East Tennessee, where he gained a reputation for hunting and storytelling. He was made a colonel in the militia of Lawrence County, Tennessee, and was elected to the Tennessee state legislature in 1821. In 1827, he was elected to the U.S. Congress where he vehemently opposed many of the policies of President Andrew Jackson, especially the Indian Removal Act. Crockett's opposition to Jackson's policies led to his defeat in the 1831 elections. He was re-elected in 1833, then narrowly lost in 1835, prompting his angry departure to Texas (then the Mexican state of Tejas) shortly thereafter. In early 1836, he took part in the Texas Revolution and died at the Battle of the Alamo. It is unclear whether he died in battle or was executed after being captured by the Mexican Army.

The Appalachian region and its people have historically been stereotyped by observers, with the basic perceptions of Appalachians painting them as backwards, rural, and anti-progressive. These widespread, limiting views of Appalachia and its people began to develop in the post-Civil War. Those who "discovered" Appalachia found it to be a very strange environment, and depicted its "otherness" in their writing. These depictions have persisted and are still present in common understandings of Appalachia today, with a particular increase of stereotypical imagery during the late 1950s and early 1960s in sitcoms. Common Appalachian stereotypes include those concerning economics, appearance, and the caricature of the "hillbilly."

The Grand Divisions are three geographic regions in the U.S. state of Tennessee, each constituting roughly one-third of the state's land area, that are geographically, culturally, legally, and economically distinct. The Grand Divisions are legally recognized in the state constitution and state law and are represented on the flag of Tennessee by the flag's three prominent stars.

The Grand Divisions, East, Middle, and West Tennessee, are sometimes referred to as "the three states of Tennessee" or "the three Tennessees".

The University of Tennessee, Knoxville (or the University of Tennessee; UT; UT Knoxville; or colloquially UTK or Tennessee) is a public land-grant research university in Knoxville, Tennessee, United States. Founded in 1794, two years before Tennessee became the 16th state, it is the flagship campus of the University of Tennessee system, with 14 colleges. It hosts more than 30,000 students from all 50 states and more than 100 foreign countries.

UT's ties to nearby Oak Ridge National Laboratory, established under UT President Andrew Holt and continued under the UT–Battelle partnership, allow for considerable research opportunities for faculty and students. Also affiliated with the university are the Howard H. Baker Jr. Center for Public Policy, the University of Tennessee Anthropological Research Facility, and the University of Tennessee Arboretum, which occupies 250 acres (100 ha) of nearby Oak Ridge. The university is a direct partner of the University of Tennessee Medical Center, which is one of two Level I trauma centers in East Tennessee.