Duchy of Urbino in the context of "Guidobaldo II della Rovere"

Giovanni Santi (c. 1435 – 1 August 1494) was an Italian painter and poet, father of Raphael Sanzio. He was born in 1435 at Colbordolo in the Duchy of Urbino. He studied under Piero della Francesca and was influenced by Fiorenzo di Lorenzo. He was court painter to the Duke of Urbino and painted several altarpieces among other things. He died in Urbino.

Pope Leo X (Italian: Leone X; born Giovanni di Lorenzo de' Medici, 11 December 1475 – 1 December 1521) was head of the Catholic Church and ruler of the Papal States from 9 March 1513 to his death in December 1521.

Born into the prominent political and banking Medici family of Florence, Giovanni was the second son of Lorenzo de' Medici, ruler of the Florentine Republic, and was elevated to the cardinalate in 1489. Following the death of Pope Julius II, Giovanni was elected pope after securing the backing of the younger members of the College of Cardinals. Early on in his rule he oversaw the closing sessions of the Fifth Council of the Lateran, but struggled to implement the reforms agreed. In 1517 he led a costly war that succeeded in securing his nephew Lorenzo di Piero de' Medici as Duke of Urbino, but reduced papal finances.

Francesco Maria II della Rovere (20 February 1549 – 23 April 1631) was the last Duke of Urbino.

Federico da Montefeltro, also known as Federico III da Montefeltro KG (7 June 1422 – 10 September 1482), was one of the most successful mercenary captains (condottieri) of the Italian Renaissance. He became the lord of Urbino in 1444, and ruled the city as its duke from 1474 until his death. In addition to his considerable reputation for martial skill and honour, he was a renowned intellectual humanist and civic leader. Montefeltro commissioned the construction of a great library, perhaps the largest of Italy after the Vatican's, complete with a team of scribes in its scriptorium. He also assembled a large humanistic court in his Ducal Palace, designed by Luciano Laurana and Francesco di Giorgio Martini.

The War of Urbino (January–September 1517) was a secondary episode of the Italian Wars.

The conflict ensued after the end of the War of the League of Cambrai (1508–16), when Francesco Maria I della Rovere decided to take advantage of the situation to recover the Duchy of Urbino, from which he had been ousted in the previous year by troops of the Papal States.