Clinical depression in the context of "Adrenal insufficiency"

Learned helplessness is the behavior exhibited by a subject after enduring repeated aversive stimuli beyond their control. In humans, learned helplessness is related to the concept of self-efficacy, the individual's belief in their innate ability to achieve goals.

Learned helplessness theory is the view that clinical depression and related mental illnesses may result from a real or perceived absence of control over the outcome of a situation.

Alzheimer's disease (AD) is a neurodegenerative disease and is the most common form of dementia, accounting for around 60–70% of cases. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, self-neglect, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the average life expectancy following diagnosis is three to twelve years.

The causes of Alzheimer's disease remain poorly understood. There are many environmental and genetic risk factors associated with its development. The strongest genetic risk factor is from an allele of apolipoprotein E. Other risk factors include a history of head injury, clinical depression, and high blood pressure. The progression of the disease is largely characterised by the accumulation of malformed protein deposits in the cerebral cortex, called amyloid plaques and neurofibrillary tangles. These misfolded protein aggregates interfere with normal cell function, and over time lead to irreversible degeneration of neurons and loss of synaptic connections in the brain. A probable diagnosis is based on the history of the illness and cognitive testing, with medical imaging and blood tests to rule out other possible causes. Initial symptoms are often mistaken for normal brain aging. Examination of brain tissue is needed for a definite diagnosis, but this can only take place after death.

Psychological abuse, often known as emotional abuse or mental abuse, is a form of abuse characterized by a person knowingly or intentionally exposing another person to a behavior that results in psychological trauma, including anxiety, chronic depression, clinical depression or post-traumatic stress disorder amongst other psychological reactions.

It is often associated with situations of controlling behavior in abusive relationships, and may include bullying, gaslighting, abuse in the workplace, amongst other behaviors that may cause an individual to feel unsafe.

Lifestyle diseases can be defined as the diseases linked to the manner in which a person lives their life. These diseases are non-communicable, and can be caused by lack of physical activity, unhealthy eating, alcohol, substance use disorders and smoking tobacco, which can lead to heart disease, stroke, obesity, type II diabetes and lung cancer. The diseases that appear to increase in frequency as countries become more industrialized and people live longer include Alzheimer's disease, arthritis, atherosclerosis, asthma, cancer, chronic liver disease or cirrhosis, chronic obstructive pulmonary disease, colitis, irritable bowel syndrome, type 2 diabetes, heart disease, hypertension, metabolic syndrome, chronic kidney failure, osteoporosis, PCOD, stroke, depression, obesity and vascular dementia.

Concerns were raised in 2011 that lifestyle diseases could soon have an impact on the workforce and the cost of health care. Treating these non-communicable diseases can be expensive. It can be critical for the patient's health to receive primary prevention and identify early symptoms of these non-communicable diseases. These lifestyle diseases are expected to increase throughout the years if people do not improve their lifestyle choices.

Mr. Robot is an American psychological techno-thriller television series created by Sam Esmail for USA Network. It stars Rami Malek as Elliot Alderson, a cybersecurity engineer and hacker with social anxiety disorder, clinical depression, and dissociative identity disorder. Elliot is recruited by an insurrectionary anarchist known as "Mr. Robot", played by Christian Slater, to join a group of hacktivists called "fsociety". The group aims to destroy all debt records by encrypting the financial data of E Corp, the largest conglomerate in the world.

The pilot premiered via online and video on demand services on May 27, 2015. In addition to Malek and Slater, the series stars an ensemble cast featuring Carly Chaikin, Portia Doubleday, Martin Wallström, Michael Cristofer, Stephanie Corneliussen, Grace Gummer, BD Wong, Bobby Cannavale, Elliot Villar, and Ashlie Atkinson. The first season debuted on USA Network on June 24, 2015; the second season premiered on July 13, 2016; and the third season premiered on October 11, 2017. The fourth and final season premiered on October 6, 2019, and concluded on December 22, 2019.

Alertness is a state of active attention characterized by high sensory awareness. Someone who is alert is vigilant and promptly meets danger or emergency, or is quick to perceive and act. Alertness is a psychological and physiological state.

Lack of alertness is a symptom of a number of conditions, including narcolepsy, attention deficit hyperactivity disorder, chronic fatigue syndrome, depression, Addison's disease, and sleep deprivation. Pronounced lack of alertness is an altered level of consciousness. States with low levels of alertness include drowsiness.

Psychoeducation (a portmanteau of psychological education) is an evidence-based therapeutic intervention for patients and their loved ones that provides information and support to better understand and cope with illness. Psychoeducation is most often associated with serious mental illness, including dementia, schizophrenia, clinical depression, anxiety disorders, eating disorders, bipolar disorder and personality disorders. The term has also been used for programs that address physical illnesses, such as cancer.

Psychoeducation teaches patients and families problem-solving and communication skills, while providing education and resources in an empathetic, supportive environment. Results from more than 30 studies indicate psychoeducation improves family well-being, lowers rates of relapse and improves recovery.

An intrusive thought is an unwelcome, involuntary thought, image, or unpleasant idea that may become an obsession, is upsetting or distressing, and can feel difficult to manage or eliminate. When such thoughts are paired with obsessive–compulsive disorder (OCD), Tourette syndrome (TS), depression, autism, body dysmorphic disorder (BDD), and sometimes attention deficit hyperactivity disorder (ADHD), the thoughts may become paralyzing, anxiety-provoking, or persistent. Intrusive thoughts may also be associated with episodic memory, unwanted worries or memories from OCD, post-traumatic stress disorder (PTSD), other anxiety disorders, eating disorders, or psychosis. Intrusive thoughts, urges, and images are of inappropriate things at inappropriate times, and generally have aggressive, sexual, or blasphemous themes.

Disrupted in schizophrenia 1 is a protein that in humans is encoded by the DISC1 gene. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell adhesion. Several studies have shown that unregulated expression or altered protein structure of DISC1 may predispose individuals to the development of schizophrenia, clinical depression, bipolar disorder, and other psychiatric conditions. The cellular functions that are disrupted by permutations in DISC1, which lead to the development of these disorders, have yet to be clearly defined and are the subject of current ongoing research. Although recent genetic studies of large schizophrenia cohorts have failed to implicate DISC1 as a risk gene at the gene level, the DISC1 interactome gene set was associated with schizophrenia, showing evidence from genome-wide association studies of the role of DISC1 and interacting partners in schizophrenia susceptibility.

Acne, also known as acne vulgaris, is a long-term skin condition that occurs when dead skin cells and oil from the skin clog hair follicles. Typical features of the condition include blackheads or whiteheads, pimples, oily skin, and possible scarring. It primarily affects skin with a relatively high number of oil glands, including the face, upper part of the chest, and back. The resulting appearance can lead to lack of confidence, anxiety, reduced self-esteem, and, in extreme cases, depression or thoughts of suicide.

Susceptibility to acne is primarily genetic in 80% of cases. The roles of diet and cigarette smoking in the condition are unclear, and neither cleanliness nor exposure to sunlight are associated with acne. In both sexes, hormones called androgens appear to be part of the underlying mechanism, by causing increased production of sebum. Another common factor is the excessive growth of the bacterium Cutibacterium acnes, which is present on the skin.

The Bell Jar is the only novel written by the American writer and poet Sylvia Plath. Originally published under the pseudonym "Victoria Lucas" in 1963, the novel is supposedly semi-autobiographical, with the names of places and people changed. The book is often regarded as a roman à clef because the protagonist's descent into mental illness parallels Plath's own experiences with what may have been clinical depression. Plath died by suicide a month after its first UK publication.

The novel was published under Plath's name for the first time in 1966. It was not published in the United States until 1971, in accordance with the wishes of both Plath's husband Ted Hughes and her mother. In the United States, the book became an instant best-seller, and has since been translated into more than forty languages.