Cleopatra VII in the context of "Mark Antony"

Hellenistic Greece is the historical period of Ancient Greece following Classical Greece and between the death of Alexander the Great in 323 BC and the annexation of the classical Greek Achaean League heartlands by the Roman Republic. This culminated at the Battle of Corinth in 146 BC, a crushing Roman victory in the Peloponnese that led to the destruction of Corinth and ushered in the period of Roman Greece. Hellenistic Greece's definitive end was with the Battle of Actium in 31 BC, when Octavian defeated Ptolemaic queen Cleopatra VII and Mark Antony, the next year taking over Alexandria, the last great center of Hellenistic Greece.

The Hellenistic period began with the wars of the Diadochi, armed contests among the former generals of Alexander the Great to carve up his empire in Europe, Asia, and North Africa. The wars lasted until 275 BC, witnessing the fall of both the Argead and Antipatrid dynasties of Macedonia in favor of the Antigonid dynasty. The era was also marked by successive wars between the Kingdom of Macedonia, the kingdom of Epirus, the Aetolian League, Achaean League, Sparta, Rhodes, kingdom of Pergamum as well as the Seleucid and Ptolemaic empires.

Cleopatra VII, the last ruler of the Ptolemaic Kingdom of Egypt, died on either 10 or 12 August, 30 BC, in Alexandria, when she was 39 years old. According to popular belief, Cleopatra killed herself by allowing an asp (Egyptian cobra) to bite her, but according to the Roman-era writers Strabo, Plutarch, and Cassius Dio, Cleopatra poisoned herself using either a toxic ointment or by introducing the poison with a sharp implement such as a hairpin. Modern scholars debate the validity of ancient reports involving snakebites as the cause of death and whether she was murdered. Some academics hypothesize that her Roman political rival Augustus (Octavian) forced her to kill herself in a manner of her choosing. The location of Cleopatra's tomb is unknown. It was recorded that Octavian allowed for her and her husband, the Roman politician and general Mark Antony, who stabbed himself with a sword, to be buried together properly.

Cleopatra's death effectively ended the final war of the Roman Republic between the remaining triumvirs Octavian and Antony, in which Cleopatra aligned herself with Antony, father to three of her children. Antony and Cleopatra fled to Egypt following their loss at the 31 BC Battle of Actium in Roman Greece, after which Octavian invaded Egypt and defeated their forces. Committing suicide allowed her to avoid the humiliation of being paraded as a prisoner in a Roman triumph celebrating the military victories of Octavian, who would become Rome's first emperor in 27 BC and be known as Augustus. Octavian, rival heir of Julius Caesar had Cleopatra's son Caesarion (also known as Ptolemy XV) killed in Egypt but spared her children with Antony and brought them to Rome. Cleopatra's death marked the end of the Hellenistic period and Ptolemaic rule of Egypt, as well as the beginning of Roman Egypt, which became a province of the Roman Empire.

Ptolemy XIII Theos Philopator (Ancient Greek: Πτολεμαῖος Θεός Φιλοπάτωρ, Ptolemaĩos; c. 62 BC – 13 January 47 BC) was Pharaoh of Egypt from 51 to 47 BC, and one of the last members of the Ptolemaic dynasty (305–30 BC). He was the son of Ptolemy XII and the brother of and co-ruler with Cleopatra VII. Cleopatra's exit from Egypt caused a civil war to break out between the pharaohs. Ptolemy later ruled jointly with his other sister, Arsinoe IV.

The siege of Alexandria was a series of skirmishes and battles occurring between the forces of Julius Caesar, Cleopatra VII, Arsinoe IV, and Ptolemy XIII, between 48 and 47 BC. During this time Caesar was engaged in a civil war against remaining Republican forces.

The siege was lifted by relief forces arriving from Syria. After a battle contesting those forces' crossing of the Nile delta, Ptolemy XIII and Arsinoe's forces were defeated.

Nefertari (also known as Nefertari Meritmut; Akkadian: Naptera) was an Egyptian queen and the first of the Great Royal Wives (or principal wives) of Ramesses the Great. She is one of the best known Egyptian queens, among such women as Cleopatra, Nefertiti, and Hatshepsut, and one of the most prominent not known or thought to have reigned in her own right. She was highly educated and able to both read and write hieroglyphs, a very rare skill at the time. She used these skills in her diplomatic work, corresponding with other prominent royals of the time. Her lavishly decorated tomb, QV66, is one of the largest and most spectacular in the Valley of the Queens. Ramesses also constructed a temple for her at Abu Simbel next to his colossal monument there.

The tomb of Antony and Cleopatra is the undiscovered burial crypt of Mark Antony and Cleopatra VII from 30 BC assumed to be located in Alexandria, Egypt.

According to historians Suetonius and Plutarch, the Roman leader Octavian permitted their burial together after he had defeated them. Their surviving children were taken to Rome, to be raised as Roman citizens. The Egyptian Ministry of Tourism and Antiquities theorizes that it is within or near a temple of Taposiris Magna, southwest of Alexandria.