Arsinoe IV in the context of "Cleopatra VII"

The reign of Cleopatra VII of the Ptolemaic Kingdom of Egypt began with the death of her father, Ptolemy XII Auletes, by March 51 BC. It ended with her suicide in August 30 BC, which also marked the conclusion of the Hellenistic period and the annexation of Egypt into a Roman province. In the style of her Greek predecessors, Cleopatra reigned over Egypt and other territories as an absolute monarch, although the Roman Republic frequently interfered in its internal affairs. Her personal rule of Egypt was characterized by a continued reliance on agriculture, extensive trade and conflict with other states, the tackling of corruption, strategic management of the bureaucracy, and ambitious building projects.

Cleopatra initially acceded to the throne alongside her younger brother Ptolemy XIII, but a fallout between them led to open civil war. Further chaos ensued when the Roman consul Julius Caesar pursued his rival Pompey into Ptolemaic Egypt, a Roman client state. Upon arrival, Caesar discovered that Pompey had been assassinated on the orders of Ptolemy XIII. Caesar attempted to reconcile the siblings, but a discontent Ptolemy XIII and his adviser Potheinos raised forces against Caesar and Cleopatra. Reinforcements lifted the siege in early 47 BC, and Ptolemy XIII died shortly afterwards in the Battle of the Nile. Arsinoe IV (Cleopatra's younger sister and a rival claimant to the throne) was exiled, and Caesar, now dictator, declared Cleopatra and her younger brother Ptolemy XIV co-rulers of Egypt. However, Caesar maintained a private affair with Cleopatra that produced a son, Caesarion, before he departed Alexandria for Rome.

Ptolemy XIII Theos Philopator (Ancient Greek: Πτολεμαῖος Θεός Φιλοπάτωρ, Ptolemaĩos; c. 62 BC – 13 January 47 BC) was Pharaoh of Egypt from 51 to 47 BC, and one of the last members of the Ptolemaic dynasty (305–30 BC). He was the son of Ptolemy XII and the brother of and co-ruler with Cleopatra VII. Cleopatra's exit from Egypt caused a civil war to break out between the pharaohs. Ptolemy later ruled jointly with his other sister, Arsinoe IV.

The Battle of the Nile in early 47 BC saw the combined Roman–Egyptian armies of Julius Caesar and Cleopatra VII defeat those of the rival Queen Arsinoe IV and King Ptolemy XIII and secure the throne of Egypt.

The early life of Cleopatra VII covers the period from Cleopatra's birth in early 69 BC to her accession to the throne during or before March 51 BC. Cleopatra was born to the reigning pharaoh of Ptolemaic Egypt, Ptolemy XII Auletes; the identity of her mother is disputed and is presumed to have been Cleopatra V or Cleopatra VI, who may have been the same person. During her early childhood, Cleopatra was brought up in the palace of Alexandria in Egypt and received a primarily Hellenistic Greek education. By adulthood she was well-versed in many languages, including Egyptian, Ethiopian, Hebrew, Arabic, Median, Parthian, Latin, and her native Koine Greek.

Cleopatra's father was a client ruler of the Roman Republic. When the Romans annexed Cyprus and Ptolemy XII's brother Ptolemy of Cyprus chose to commit suicide rather than go into exile, Ptolemy XII became unpopular with the masses in Egypt for offering no public reaction to the events. He and a daughter, ostensibly Cleopatra and not Arsinoe IV, were exiled from Egypt during a revolt. This allowed Cleopatra's older sister Berenice IV to claim the throne in 58 BC, ruling jointly with Cleopatra VI. Ptolemy XII and Cleopatra traveled to Roman Italy, staying outside Rome at the villa of their Roman patron, Pompey the Great. After Ptolemy XII orchestrated the assassinations of Berenice IV's diplomats in Rome, seeking to gain Roman favor, he and Cleopatra left the city's hostile environment and settled at Ephesus in Anatolia.