The IRT Lexington Avenue Line (also known as the IRT East Side Line and the IRT Lexington–Fourth Avenue Line) is one of the lines of the A Division of the New York City Subway, stretching from Lower Manhattan north to 125th Street in East Harlem. The line is served by the 4, ​5, ​6, and <6> trains.
The line was constructed in two main portions by the Interborough Rapid Transit Company (IRT), a private operator. The first portion, from City Hall north to 42nd Street, was opened between 1904 and 1908, and is part of the first subway line in the city. The original subway turned west across 42nd Street at the Grand Central station, then went north at Broadway, serving the present-day IRT Broadway–Seventh Avenue Line. The second portion of the line, north of 42nd Street, was constructed as part of the Dual Contracts, which were signed between the IRT; the Brooklyn Rapid Transit Company, via a subsidiary; and the City of New York.