The Chalcedonian schism, also known as the Monophysite schism, is the break of communion between the Oriental Orthodox Churches and the Great Church (which later became the Eastern Orthodox Church and Catholic Church) in the aftermath of the Council of Chalcedon. Although the bishops at Chalcedon greatly respected Cyril of Alexandria and used his writings as a benchmark for orthodoxy, opponents of the council believed that the Chalcedonian Definition, which states that Christ is "acknowledged in Two Natures", was too close to Nestorianism and contradicts Cyril's formula "one nature of God the Word incarnate". The Council had also deposed the Pope of Alexandria, Dioscorus, but his supporters continued to consider him their rightful Pope, refusing to recognise the council-appointed Proterius.
The anti-Chalcedonian strongholds were in Egypt, Palestine and later Syria. Over the next century, their communities gradually separated from the official church of the Byzantine Empire, eventually becoming the Oriental Orthodox Churches. The imperial government made many attempts to mend the schism, generally by trying to compromise between the two positions, but these attempts only created further heresies and schisms. The Arab conquests of the Levant and of Egypt in the 7th century fossilised the schism, but ecumenical dialogue between Chalcedonian and non-Chalcedonian Christians has been renewed since the 20th century.