Calydon (son of Aetolus) in the context of "Pleuron of Aetolia"

Protogeneia (/ˌprɒtə.dʒəˈnaɪə/; Ancient Greek: Πρωτογένεια means "the firstborn"), in Greek mythology, may refer to:

• Protogeneia, a Phthian princess as the daughter of King Deucalion of Thessaly and Pyrrha, mythological progenitors of the Hellenes. She was the sister of Hellen and Amphictyon, and possibly of Thyia and Pandora II, Melantho (Melanthea) and Candybus. By Zeus, Protogeneia became the mother of Opus, Aethlius, Aetolus and possibly of Dorus.
• Protogeneia, also called Cambyse, daughter of the above Opus. Zeus carried her off from the land of the Epeans and became by her, on mount Maenalus in Arcadia, the father of Opus II. She was later received by Locrus who for being childless, married Protogeneia and adopted her son Opus as his own.
• Protogeneia, a Calydonian princess as the daughter of King Calydon and Aeolia, daughter of Amythaon, and thus sister to Epicaste. By Ares, Protogeneia became the mother of Oxylus of Aetolia.
• Protogeneia, an Athenian princess as the eldest of the daughters of King Erechtheus and probably Praxithea, daughter of Phrasimus and Diogeneia. She and her sister Pandora committed suicide when Erechtheus sacrificed Chthonia, another sister of theirs. Protogeneia's other sisters were Procris, Creusa, Oreithyia, Merope while her possible brothers were Cecrops, Pandorus, Metion, Orneus, Thespius, Eupalamus and Sicyon.

In Greek mythology, Aeolia (Ancient Greek: Αἰολία, romanized: Aiolía) daughter of Amythaon and wife of Calydon, eponym of the city in Aetolia. She had two daughters namely Epicaste, wife of Agenor and Protogeneia, mother of Oxylus by Ares.

Epicaste (/ˌɛpɪˈkæstiː/; Ancient Greek: Ἐπικάστη Epikaste) or Epicasta (/ˌɛpɪˈkæstə/) is a name attributed to five women in Greek mythology.

• Epicaste, a Calydonian princess as daughter of King Calydon by Aeolia, daughter of Amythaon, and thus, sister of Protogeneia. She married her cousin Agenor, son of King Pleuron, and had by him children: Porthaon, Demonice, and possibly Thestius.
• Epicaste, an Elean princess as daughter of King Augeas. She bore Heracles a son, Thestalus.
• Epicaste, another name for Jocasta/Iocaste, used by Homer.
• Epicaste, wife of Clymenus, son of Teleus of Argos, and mother of Harpalyce, Idas, and Therager.
• Epicaste, daughter of Nestor and mother of Homer himself by Telemachus, son of Odysseus.

In Greek mythology, Agenor (/əˈdʒiːnɔːr/; Ancient Greek: Ἀγήνωρ or Αγήνορι Agēnor; English translation: 'heroic, manly') was a son of King Pleuron of Aetolia and Xanthippe, and grandson of Aetolus. His siblings were Stratonice, Sterope and Laophonte. Agenor married his cousin Epicaste, the daughter of Calydon, who became by him the mother of Porthaon and Demonice. According to Pausanias, Thestius, the father of Leda, was likewise a son of this Agenor.