Blood donation in the context of "Whole blood"

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⭐ Core Definition: Blood donation

A blood donation occurs when a person voluntarily has blood drawn and used for transfusions and/or made into blood products and biopharmaceutical medications by a process called fractionation (separation of whole blood components). A donation may be of whole blood, or of specific components directly (apheresis). Blood banks often participate in the collection process as well as the procedures that follow it.

In the developed world, most blood donors are unpaid volunteers who donate blood for a community supply. In some countries, established supplies are limited and donors usually give blood when family or friends need a transfusion (directed donation). Many donors donate for several reasons, such as a form of charity, general awareness regarding the demand for blood, increased confidence in oneself, helping a personal friend or relative, and social pressure. Despite the many reasons that people donate, not enough potential donors actively donate. However, this is reversed during disasters when blood donations increase, often creating an excess supply that will have to be later discarded. In countries that allow paid donation some people are paid, and in some cases there are incentives other than money such as paid time off from work. People can also have blood drawn for their own future use (autologous donation). Donating is relatively safe, but some donors have bruising where the needle is inserted or may feel faint.

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👉 Blood donation in the context of Whole blood

Whole blood (WB) is human blood from a standard blood donation. It is used in the treatment of hemorrhagic shock, in exchange transfusion, and when people donate blood to themselves (autologous transfusion). One unit of whole blood (approximately 450 mL) increases hemoglobin levels by about 10 g/L. Cross matching is typically done before the blood is given. It is either given intravenously or through Intraosseous infusion.

Side effects include red blood cell breakdown, high blood potassium, infection, volume overload, lung injury, and allergic reactions such as anaphylaxis. Whole blood is made up of red blood cells, white blood cells, platelets, and blood plasma. It is best within a day of collection; however, it can be stored for up to three weeks if refrigerated (1-6 °C). The blood is typically combined with an anticoagulant and preservative during the collection process.

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Blood donation in the context of Bleeding

Bleeding, hemorrhage, haemorrhage or blood loss, is blood escaping from the circulatory system from damaged blood vessels. Bleeding can occur internally, or externally either through a natural opening such as the mouth, nose, ear, urethra, vagina, or anus, or through a puncture in the skin.Hypovolemia is a massive decrease in blood volume, and death by excessive loss of blood is referred to as exsanguination. Typically, a healthy person can endure a loss of 10–15% of the total blood volume without serious medical difficulties (by comparison, blood donation typically takes 8–10% of the donor's blood volume). The stopping or controlling of bleeding is called hemostasis and is an important part of both first aid and surgery.

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Blood donation in the context of Antiserum

In immunology, antiserum is a blood serum containing antibodies (either monoclonal or polyclonal) that is used to spread passive immunity to many diseases via blood donation (plasmapheresis). For example, convalescent serum, or passive antibody transfusion from a previous human survivor, was the only known effective treatment for Ebola infection with a high success rate of 7 out of 8 patients surviving.

Antisera are widely used in diagnostic virology laboratories. The most common use of antiserum in humans is as antitoxin or antivenom to treat envenomation.

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Blood donation in the context of Transfusion transmitted infection

A transfusion–transmitted infection (TTI) or transfusion–associated infection is a pathogen which is transmissible through donated blood and can give rise to infection in the recipient by way of transfusion. The term is usually limited to known pathogens, but also sometimes includes agents such as simian foamy virus which are not known to cause disease.

Following a number of highly publicized incidents throughout the 1970s-1980s, preventing disease transmission through blood donation is addressed through a series of safeguards. Blood safety measures that limit this risk of disease transmission through blood donation are considered essential in upholding public trust in blood donation, and to avoid harm to blood recipients who are frequently vulnerable to severe disease. The World Health Organization recommends screening potential blood donors for signs and symptoms of disease and for activities that might put them at risk for infection, including mandatory testing of donated blood for relevant pathogens prior to transmission, sometimes with several different methodologies. Additional safeguards, such as leukoreduction and pathogen inactivation can be applied, and are frequently mandatory. If a local supply is not safe, select blood may be imported from other areas.

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Blood donation in the context of Blood product

A blood product is any therapeutic substance prepared from blood, usually human blood; in some medicolegal contexts, the term refers specifically to human-blood-derived products. Blood products include whole blood, blood components, and blood plasma derivatives. Blood components include red blood cell concentrates or suspensions; platelets produced from whole blood or via apheresis; granulocytes; fresh frozen plasma; cryoprecipitates; antisera; and others. Some products for topical use, such as serum eye drops, have also been recently classified as blood components. Plasma derivatives are plasma proteins prepared under pharmaceutical manufacturing conditions, including: albumin; coagulation factor concentrates; and immunoglobulins.

Human blood and blood products come from blood donation, which can be from one person to another or from a person to themselves (such as when saving one's own blood for use after an upcoming surgical procedure).

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Blood donation in the context of Blood bank

A blood bank is a center where blood gathered as a result of blood donation is stored and preserved for later use in blood transfusion. The term "blood bank" typically refers to a department of a hospital usually within a clinical pathology laboratory where the storage of blood product occurs and where pre-transfusion and blood compatibility testing is performed. However, it sometimes refers to a collection center, and some hospitals also perform collection. Blood banking includes tasks related to blood collection, processing, testing, separation, and storage.

For blood donation agencies in various countries, see list of blood donation agencies and list of blood donation agencies in the United States.

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