Base of skull in the context of Endocranium

The foramen magnum is a large, oval-shaped opening in the occipital bone of the skull. It is one of the several oval or circular openings (foramina) in the base of the skull. The spinal cord, an extension of the medulla oblongata, passes through the foramen magnum as it exits the cranial cavity. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the vertebral arteries, the anterior and posterior spinal arteries, the tectorial membranes and alar ligaments. It also transmits the accessory nerve into the skull.

Bipedal species typically display an anteriorly placed foramen magnum to balance the head atop the vertebral column. In hominins, this anterior shift is uniquely coupled with increased cranial base flexion. Studies of foramen magnum position have shown its relationship to posture and locomotion. This forward placement is apparent in bipedal hominins such as modern humans, Australopithecus africanus, and Paranthropus boisei. This common feature of bipedal hominins is the driving argument used by the paleontologist Michel Brunet to support that Sahelanthropus tchadensis was bipedal and may be the earliest known bipedal hominin. The recognition of this feature has given scientists another tool for identifying bipedal mammals.

Otorhinolaryngology (/oʊtoʊˌraɪnoʊˌlærɪnˈɡɒlədʒi/ oh-toh-RY-noh-LARR-in-GOL-ə-jee, abbreviated ORL and also known as otolaryngology, otolaryngology – head and neck surgery (ORL–H&N or OHNS), or ear, nose, and throat (ENT) ) is a surgical subspecialty within medicine that deals with the surgical and medical management of conditions of the head and neck. Doctors who specialize in this area are called otorhinolaryngologists, otolaryngologists, head and neck surgeons, or ENT surgeons or physicians.

Patients seek treatment from an otorhinolaryngologist for diseases of the ear, nose, throat, base of the skull, head, and neck. These commonly include functional diseases that affect the senses and activities of eating, drinking, speaking, breathing, swallowing, and hearing. In addition, ENT surgery encompasses the surgical management of cancers and benign tumors and reconstruction of the head and neck as well as plastic surgery of the face, scalp, and neck.

Cholesteatoma is a destructive and expanding growth consisting of keratinizing squamous epithelium in the middle ear and/or mastoid process. Cholesteatomas are not cancerous as the name may suggest, but can cause significant problems because of their erosive and expansile properties. This can result in the destruction of the bones of the middle ear (ossicles), as well as growth through the base of the skull into the brain. They often become infected and can result in chronically draining ears. Treatment almost always consists of surgical removal.

Endochondral ossification is one of the two essential pathways by which bone tissue is produced during fetal development and bone repair of the mammalian skeletal system, the other pathway being intramembranous ossification. Both endochondral and intramembranous processes initiate from a precursor mesenchymal tissue, but their transformations into bone are different. In intramembranous ossification, mesenchymal tissue is directly converted into bone. On the other hand, endochondral ossification starts with mesenchymal tissue turning into an intermediate cartilage stage, which is eventually substituted by bone.

Endochondral ossification is responsible for development of most bones including long and short bones, the bones of the axial (ribs and vertebrae) and the appendicular skeleton (e.g. upper and lower limbs), the bones of the skull base (including the ethmoid and sphenoid bones) and the medial end of the clavicle. In addition, endochondral ossification is not exclusively confined to embryonic development; it also plays a crucial role in the healing of fractures.