Artemisia annua in the context of "1,2,4-trioxane"

Play Trivia Questions online!

 or

Skip to study material about Artemisia annua in the context of "1,2,4-trioxane"

⭐ Core Definition: Artemisia annua

Artemisia annua, also known as sweet wormwood, sweet annie, sweet sagewort, annual mugwort or annual wormwood, is a common type of wormwood native to temperate Asia, but naturalized in many countries including scattered parts of North America.

The chemical compound artemisinin, which is isolated from A. annua, is a medication used to treat malaria due to Plasmodium falciparum, the deadliest species of malarial parasite. Discovery of artemisinin and its antimalarial properties made the Chinese scientist Tu Youyou recipient of the 2011 Lasker Prize and 2015 Nobel Prize in Physiology or Medicine.

↓ Menu

👉 Artemisia annua in the context of 1,2,4-trioxane

1,2,4-Trioxane is one of the isomers of trioxane. It has the molecular formula C3H6O3 and consists of a six membered ring with three carbon atoms and three oxygen atoms. The two adjacent oxygen atoms form a peroxide functional group and the other forms an ether functional group. It is like a cyclic acetal but with one of the oxygen atoms in the acetal group being replaced by a peroxide group.

1,2,4-Trioxane itself has not been isolated or characterized, but rather only studied computationally. However, it constitutes an important structural element of some more complex organic compounds. The natural compound artemisinin, isolated from the sweet wormwood plant (Artemisia annua), and some semi-synthetic derivatives are important antimalarial drugs containing the 1,2,4-trioxane ring. Completely synthetic analogs containing the 1,2,4-trioxane ring are important potential improvements over the naturally derived artemisinins. The peroxide group in the 1,2,4-trioxane core of artemisinin is cleaved in the presence of the malaria parasite leading to reactive oxygen radicals that are damaging to the parasite.

↓ Explore More Topics
In this Dossier

Artemisia annua in the context of Artemisinin

Artemisinin (/ˌɑːrtɪˈmiːsɪnɪn/) and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. It was discovered in 1972 by Tu Youyou, who shared the 2015 Nobel Prize in Physiology or Medicine for her discovery. Artemisinin-based combination therapies (ACTs) have become standard treatment worldwide for P. falciparum malaria as well as malaria due to other species of Plasmodium. Artemisinin can be extracted from the herb Artemisia annua (sweet wormwood), which is used in traditional Chinese medicine. Alternatively, it can be prepared by a semi-synthetic method from a precursor compound that can be produced using a genetically engineered yeast, which is much more efficient than extraction from the plant.

Artemisinin and its derivatives are all sesquiterpene lactones containing an unusual peroxide bridge. This endoperoxide 1,2,4-trioxane ring is responsible for their antimalarial properties. Few other natural compounds with such a peroxide bridge are known.

↑ Return to Menu
LINKED FROM (PARENTS)
← Artemisinin ← 1,2,4-trioxane
LINKS TO (CHILDREN)
Artemisia (plant) → Chemical compound → Artemisinin → Malaria → Plasmodium falciparum → Tu Youyou → Lasker-DeBakey Clinical Medical Research Award → Nobel Prize in Physiology or Medicine →