Apollo command module in the context of "Apollo 11"

As part of the Apollo program by NASA, 24 astronauts flew nine missions to the Moon between December 1968 and December 1972. During six successful two-man landing missions, twelve men walked on the lunar surface, six of whom drove Lunar Roving Vehicles as part of the last three missions. Three men have been to the Moon twice, one orbited once and took a circumlunar trajectory the second time, while the other two landed once apiece. Apart from these 24 men, no human being has gone beyond low Earth orbit. As of December 2025, five of the 24 remain alive. A number of non-human animals have circled or orbited it, including two tortoises, several turtles, and five mice.

Apollo missions 8 and 10–17 were the nine crewed missions to the Moon. Apollo 4–6 and AS-201 and AS-202 were uncrewed, while AS-203 is considered a test flight. The Apollo program included three other crewed missions: Apollo 1 (AS-204) did not launch and its crew died in a ground-based capsule fire, while Apollo 7 and Apollo 9 were low Earth orbit missions that tested spacecraft components and docking maneuvers. Apollo missions 18, 19, and 20 were canceled. Twelve astronauts later flew unused Apollo command modules in the Apollo Applications Program's Skylab and Apollo–Soyuz Test Project. Of the 24 astronauts who flew to the Moon, two went on to command a Skylab mission, one commanded Apollo–Soyuz, one flew as commander for Approach and Landing Tests of the Space Shuttle, and two commanded orbital Space Shuttle missions.

Fe, Fi, Fo, Fum, and Phooey were five mice who traveled to the Moon and circled it 75 times on the 1972 Apollo 17 mission. NASA gave them identification numbers A3305, A3326, A3352, A3356, and A3400, and their nicknames were given by the Apollo 17 crew (Eugene Cernan, Harrison Schmitt, and Ronald Evans). The four male mice, one female mouse, and Evans orbited the Moon for a record-setting six days and four hours in the Apollo command module America as Cernan and Schmitt performed the Apollo program's last lunar excursions.

The mice traveled in individual compartments of tubes inside an aluminum container with "a sufficient food supply, temperature control, and a reserve of potassium superoxide that absorbed the CO₂ from their respiration and provided them with fresh oxygen." One male mouse, A-3352, died during the trip, and the four survivors were euthanized and dissected for their expected biological information upon their return from the Moon.

Spaceship Earth (or Spacecraft Earth or Spaceship Planet Earth) is a worldview encouraging everyone on Earth to act as a harmonious crew working toward the greater good.