Ali al-Ridha in the context of "Uyoun Akhbar Al-Ridha"

Wali al-Ahd (Arabic: ولي العهد, romanized: Walī al-ʿAhd) is the Arabic and Islamic term for a designated heir of a ruler, or crown prince.

The Fourth Fitna, Fourth Muslim Civil War, or Great Abbasid Civil War resulted from the conflict between the brothers al-Amin and al-Ma'mun over the succession to the throne of the Abbasid Caliphate. Their father, Caliph Harun al-Rashid, had named al-Amin as the first successor, but had also named al-Ma'mun as the second, with Khurasan granted to him as an appanage. Later a third son, al-Qasim, was designated as third successor. After Harun died in 809, al-Amin succeeded him in Baghdad. Encouraged by the Baghdad court, al-Amin began trying to subvert the autonomous status of Khurasan, and al-Qasim was quickly sidelined. In response, al-Ma'mun sought the support of the provincial élites of Khurasan and made moves to assert his own autonomy. As the rift between the two brothers and their respective camps widened, al-Amin declared his own son Musa as his heir and assembled a large army. In 811, al-Amin's troops marched against Khurasan, but al-Ma'mun's general Tahir ibn Husayn defeated them in the Battle of Ray, and then invaded Iraq and besieged Baghdad itself. The city fell after a year, al-Amin was executed, and al-Ma'mun became Caliph.

Al-Ma'mun chose to remain in Khurasan, however, rather than coming to the capital. This allowed the power vacuum which the civil war had fostered in the Caliphate's provinces to grow, and several local rulers sprang up in Jazira, Syria and Egypt. In addition, a series of Alid uprisings occurred, beginning with Abu'l-Saraya at Kufa and spreading to southern Iraq, the Hejaz, and Yemen. The pro-Khurasani policies followed by al-Ma'mun's powerful chief minister, al-Fadl ibn Sahl, and al-Ma'mun's eventual espousal of an Alid succession in the person of Ali al-Ridha, alienated the traditional Baghdad élites, who saw themselves increasingly marginalized. Consequently, al-Ma'mun's uncle Ibrahim was proclaimed rival caliph at Baghdad in 817, forcing al-Ma'mun to intervene in person. Fadl ibn Sahl was assassinated and al-Ma'mun left Khurasan for Baghdad, which he entered in 819. The next years saw the consolidation of al-Ma'mun's authority and the re-incorporation of the western provinces against local rebels, a process not completed until the pacification of Egypt in 827. Some local rebellions, notably that of the Khurramites, dragged on for far longer, into the 830s.

Al-Risala al-Dhahabiyya (Arabic: ٱلرِّسَالَة ٱلذَّهَبِيَّة, Arabic pronunciation: ['rɪsælætæ 'ðæhæ'biæ]; "The Golden Treatise") is a medical dissertation on health and remedies attributed to Ali ibn Musa al-Ridha (765–818), the eighth Imam of Shia Islam. He wrote this dissertation in accordance with the demand of Ma'mun, the caliph of the time. It is revered as the most precious Islamic literature in the science of medicine, and was entitled "the golden treatise" as Ma'mun had ordered it written in gold ink. The chain of narrators is said to reach Muhammad ibn Jumhoor or al-Hassan ibn Muhammad al-Nawfali who is described as "highly esteemed and trustworthy" by al-Najjashi.

The treatise of Ali al-Ridha includes scientific branches such as Anatomy, Physiology, Chemistry and Pathology when medical science was still primitive. According to the treatise, one's health is determined by four humors of blood, yellow bile, black bile and phlegm, the suitable proportion of which maintains the health. The liver plays an important role in producing and maintaining the required proportions in the body. Ali al-Ridha describes the body as a kingdom whose king is the heart while the (blood) vessels, the limbs, and the brain are the laborers. The issue of the authorship and the transmission of the text has been critically analysed in the studies by Speziale (2004) and Speziale - Giurini (2009).

Sahifah of al-Ridha (Arabic: صَّحِيفَة ٱلرِّضَا, Ṣaḥīfah ar-Riḍā, lit. "Pages of al-Ridha"), also known as Sahifat of al-Reza and Sahifat al-Imam al-Ridha ("Book of Imam al-Ridha"), is a collection of 240 hadiths attributed to Ali ibn Musa al-Ridha, the eighth Shia Imam.

The Sahifah is one of the major sources of Shia belief and has attracted the attention of Shia scholars such as Ibn Babawayh and Sheikh Tabarsi. It contains hadiths on various topics including the invocation of Allah; the importance of praying five times a day and of saying the prayer for the dead; the excellence of the household of Muhammad, of the believer, of good manners, of the names Muhammad and Ahmad, of various foods, fruits, and ointments, of obeying parents, of strengthening the bonds of kinship, and of jihad; a warning against cheating, backbiting, or tattling; and other miscellaneous traditions. The section on Muhammad's household discusses each of its fourteen members separately.